Body temperature cycles: Gatekeepers of circadian clocks

Morf, Jörg; Schibler, Ueli

doi:10.4161/cc.23670

Cited by 48 publications

(38 citation statements)

References 9 publications

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“…Stem cells might fail to respond to normal cues, or they might themselves represent a heterogeneous population that responds to different cues. Finally, the epidermal stem cells in which clock heterogeneity has been convincingly documented are themselves in a unique environment of extreme temperature variation, and temperature represents an important entrainment signal to peripheral oscillators (Brown et al, 2002;Morf and Schibler, 2013). Therefore, the epidermal stem cells might simply be confused by conflicting environmental signals.…”

Section: Discussionmentioning

confidence: 99%

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

Brown

2014

Development

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A biological 'circadian' clock conveys diurnal regulation upon nearly all aspects of behavior and physiology to optimize them within the framework of the solar day. From digestion to cardiac function and sleep, both cellular and systemic processes show circadian variations that coincide with diurnal need. However, recent research has shown that this same timekeeping mechanism might have been co-opted to optimize other aspects of development and physiology that have no obvious link to the 24 h day. For example, clocks have been suggested to underlie heterogeneity in stem cell populations, to optimize cycles of cell division during wound healing, and to alter immune progenitor differentiation and migration. Here, I review these circadian mechanisms and propose that they could serve as metronomes for a surprising variety of physiologically and medically important functions that far exceed the daily timekeeping roles for which they probably evolved.

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Section: Discussionmentioning

confidence: 99%

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

Brown

2014

Development

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“…The CIRP's rhythmic expression is inversely regulated by temperature cycles but not by the local oscillators [38]. The CIRP binds to hundreds of target mRNAs, including in the untranslated region of the Clock mRNA, and facilitates Clock's translocation from the nucleus to the cytoplasm, which influences the clockwork robustness in a temperature-dependent fashion [51]. The importance of systemic cues such as temperature cycles for the peripheral oscillators is emphasized by the fact that the Per2 mRNA and several other transcripts remain cyclic even in hepatocytes with a conditionally inhibited local circadian clockwork, because their levels are presumably driven by temperature cycles controlled by a fully functional SCN [52].…”

Section: Introductionmentioning

confidence: 99%

Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles

Sládek

Sumová

2013

PLoS ONE

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The functional state of the circadian system of spontaneously hypertensive rats (SHR) differs in several characteristics from the functional state of normotensive Wistar rats. Some of these changes might be due to the compromised ability of the central pacemaker to entrain the peripheral clocks. Daily body temperature cycles represent one of the important cues responsible for the integrity of the circadian system, because these cycles are driven by the central pacemaker and are able to entrain the peripheral clocks. This study tested the hypothesis that the aberrant peripheral clock entrainment of SHR results from a compromised peripheral clock sensitivity to the daily temperature cycle resetting. Using cultured Wistar rat and SHR fibroblasts transfected with the circadian luminescence reporter Bmal1-dLuc, we demonstrated that two consecutive square-wave temperature cycles with amplitudes of 2.5°C are necessary and sufficient to restart the dampened oscillations and entrain the circadian clocks in both Wistar rat and SHR fibroblasts. We also generated a phase response curve to temperature cycles for fibroblasts of both rat strains. Although some of the data suggested a slight resistance of SHR fibroblasts to temperature entrainment, we concluded that the overall effect it too weak to be responsible for the differences between the SHR and Wistar in vivo circadian phenotype.

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“…Based on our results, a greater pharmacological efficacy was found during the photoperiod, which was reflected by a shorter latency period and a longer duration of effect. These findings, albeit more easily explained in the context of the intrathecal block, may also be related to the influence of the increase in body temperature on the decline in the pKa of the local anaesthetic (Morf & Schibler, 2013), which therefore decreased the length of the latency period (Kamaya et al, 1983). The consequence of this decrease in the pKa is an increase in the non-ionised form of the local anaesthetic, which enhances its diffusion capacity and thus reduces the onset time of its effect, mainly at the end of the photoperiod.…”

Section: Discussionmentioning

confidence: 91%

The influence of women’s attachment style on the chronobiology of labour pain, analgesic consumption and pharmacological effect

Costa-Martins

Pereira

Martins

et al. 2014

Chronobiology International

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Circadian variation in biological rhythms has been identified as affecting both labour pain and the pharmacological properties of analgesics. In the context of pain, there is also a growing body of evidence suggesting the importance of adult attachment. The purpose of this study was to examine whether labour pain, analgesic consumption and pharmacological effect are significantly affected by the time of day, and to analyse whether this circadian variation is influenced by women's attachment style. This prospective observational study included a sample of 81 pregnant women receiving patientcontrolled epidural analgesia (PCEA). Attachment was assessed with the Adult Attachment ScaleRevised (AAS-R). The perceived intensity of labour pain in the early stage of labour (3 cm of cervical dilatation and before the administration of PCEA) was measured using a visual analogue scale (VAS).Pain was also indirectly assessed by measuring the consumption of anaesthetics. The latency period and the duration of effect were recorded for a chronopharmacology characterisation. Pain, as assessed with the VAS, was significantly higher in the night-time group than in the daytime group. An insecure attachment style was significantly associated with greater labour pain at 3 cm of cervical dilatation (p < 0.001) and before the beginning of analgesia (p < 0.001) as well as with higher analgesic consumption and lower pharmacological efficacy (p < 0.05). The time of day was significantly associated with the pharmacological effect: the latency period was longer at night, and the duration of the pharmacological effect was longer during the daytime. The interaction between time of day and attachment style was not significant for any of the study variables. Our results provide evidence of the importance of circadian variation in studying labour pain and the pharmacological effect of labour analgesia involving epidural blockage with a PCEA regimen. Moreover, although there was no evidence that attachment style influenced the circadian variation, these data emphasise that insecure attachment patterns are a risk factor for greater labour pain and analgesic consumption, which should be considered in pain management approaches.

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Body temperature cycles: Gatekeepers of circadian clocks

Cited by 48 publications

References 9 publications

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles

The influence of women’s attachment style on the chronobiology of labour pain, analgesic consumption and pharmacological effect

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