Objectives: To investigate the value of changes in P wave morphology and duration detected by surface electrocardiogram (ECG) during proximal coronary sinus (PCS) and low lateral right atrial (LLRA) stimulation as a marker for complete bidirectional isthmus conduction block in the procedure of typical atrial flutter ablation. Methods: Morphology, duration, and ratio of a positive terminal P wave were estimated in 52 typical atrial flutter patients before and after radiofrequency catheter ablation (RFCA). Results: Atrial flutter ablation resulted in a complete bidirectional isthmus block in all 52 patients. The terminal portion of the P wave towards a positive morphology was detected in 90.7% (47/52) patients both during PCS and LLRA stimulation. These changes were predominantly observed in the inferior leads. Positive morphological changes of the terminal P wave portion and the measured P wave ratio (40% ± 12%) in the inferior leads indicating bidirectional isthmus conduction block with a sensitivity of 87.5% and a specificity of 91.7% were observed. An increment of 20 ms or more in P wave duration during the PCS stimulation and 10 ms or more during the LLRA stimulation indicating the conduction block with a sensitivity of 90% and a specificity of 100%. Conclusions: The variation of P wave morphology and duration in inferior leads of the surface ECG is a helpful technique to assess the complete bidirectional isthmus conduction block in the procedure of typical atrial flutter ablation.
IntroductionPrevious studies demonstrated that the mechanism of typical atrial flutter was a macro-reentrant circuit in the right atrium. The isthmus between the tricuspid annulus and the inferior vena cava is a critical area in the reentrant circuit. Radiofrequency catheter ablation (RFCA) in the isthmus has been shown to be an effective approach to eliminate atrial flutter. 1 -4 Initially, endpoints of the ablation procedure were termination and noninducibility of atrial flutter. This approach resulted in a recurrence rate of up to 30%. 5,6 Subsequently, induction of complete bidirectional isthmus conduction block was introduced as a standard endpoint for atrial flutter ablation with a markedly higher success rate and lower recurrence rate. 7 -9 However, endocardial documentation of changes that indicate bidirectional isthmus block needs more electrodes comparatively, which increases costs and duration for procedure and irradiation. Therefore, 1 simple and cost effective approach using surface ECG to predict the bidirectional isthmus conduction block is needed and would be valuable to improve the sensitivity and specificity of the diagnosis, especially in patients in whom the coronary sinus (CS) cannot be cannulated or the Halo catheter position is unstable. In the present study, we evaluated the value of changes in P wave morphology and duration of surface ECG during proximal coronary sinus (PCS) and low lateral right atrial (LLRA) stimulation in predicting the bidirectional