Body Surface Frequency–Phase Mapping of Atrial Fibrillation

Definition of a Sensitivity Profile for Drug Treatment and Identification on Clinical Biomarkers in Atrial Fibrillation

“…As previously mentioned (Atienza et al, 2021), ECGi is a non-invasive electrocardiographic system that enables to record de Body Surface Potential Mapping to later estimate the intracardiac electrical activity. To calculate these intracardiac potentials, a transformation matrix is calculated, based on the 3D personalized anatomy of the patient's torso, together with the specific disposition of the patches over it.…”

“…On the other hand, clinical records, electrical signals and medical images provide physicians and researchers with massive amount of information. This opens an opportunity for identifying specific phenotypic, clinical, and outcome patterns that could be useful for tailoring individualized strategies for treatment (Atienza et al, 2021). However large and multidimensional big data are extremely difficult to analyze and interpret with conventional statistical tools.…”

“…The ECGi methodology used in this study has been previously described in other publications from our group (Rodrigo et al, 2014(Rodrigo et al, , 2020Atienza et al, 2021). Briefly, BSPM signals were recorded from patients during AF episodes including a total of 63 electrodes homogeneously distributed over the torso of the patient (Figure 5.1.).…”

“…Signals were recorded in resting state in case of the outpatient group or under anesthesia in case of ablation procedure at a sampling frequency of 1kHz. The geometry of the torso was reconstructed from a video to identify the electrode patch location and processed (Atienza et al, 2021;Rodrigo et al, 2014Rodrigo et al, , 2020.…”