Body surface area adapted iopromide 300mg/ml versus 370mg/ml contrast medium injection protocol: Influence on quantitative and clinical assessment in combined PET/CT

No clinically relevant differences between positron emission tomography (PET) reconstructions based on low‐dose or contrast‐enhanced CT in combined integrated multiphase 18F‐Fluorethylcholine PET/CT for prostate cancer

“…However, in FDG PET/CT it has been shown that no significant quantitative or qualitative differences in PET reconstruction resulted from the use of different contrast medium injection protocols. 10,14,15 The present results echo those of studies performed in FDG PET/CT, where similar statistically significant, but not clinically relevant increases in quantitative measures of radionuclide uptake were observed. [11][12][13] Considering the similarities between the present results and similar studies in FDG PET/CT, we would hypothesise that the results from FDG PET/CT on the issue of contrast medium (a) (b) (c) (d) Fig.…”

“…To the best of our knowledge, the effects of the use of ceCT in PET reconstruction in FCH‐PET/CT have not been studied before. However, in FDG PET/CT it has been shown that no significant quantitative or qualitative differences in PET reconstruction resulted from the use of different contrast medium injection protocols . The present results echo those of studies performed in FDG PET/CT, where similar statistically significant, but not clinically relevant increases in quantitative measures of radionuclide uptake were observed .…”

“…However, the use of ceCT for attenuation correction in PET/CT may be associated with reconstruction artefacts such as erroneously high tracer uptake values for contrast‐enhanced structures . At least for 18 F‐2‐deoxy‐fluoroglucose (FDG) PET/CT, a number of studies have shown that such influence may be statistically significant but lack clinical relevance …”

“…8,9 At least for 18 F-2-deoxyfluoroglucose (FDG) PET/CT, a number of studies have shown that such influence may be statistically significant but lack clinical relevance. [10][11][12][13][14][15] However, in prostate cancer patients, typical lymph node metastases are quite often small and can show only minor contrast with the surrounding background. Therefore, even minor changes in the reconstructed FCH distribution could conceivably lead to differences in the clinical assessment of PCA patients.…”

Improving Patient to Patient CT Value Uniformity with an Individualized Contrast Medium Protocol Tailored to Body Weight and Contrast Medium Concentration in Coronary CT Angiography

“…CT attenuation in target vessels for all included subjects was measured by a radiologist with 11-year experience in cardiovascular imaging diagnosis who was blinded to the clinical data of patients and the CM injection protocols. Coronary artery segments were defined based on New York Heart Association (NYHA) coronary segment definition[ 6 ]. CT attenuation values of the following vessels were measured: aortic opening (AO) at the level of left coronary artery opening, left ventricle (LV) at the level of bicuspid valve opening, proximal segment of left anterior descending branch (LAD), proximal segment of left circumflex branch (LCX), proximal segment of right coronary artery (RCA), and distal segment of right coronary artery (RCA-PDA) or posterior descending coronary artery (PDA).…”