Body stalk anomaly in Denmark during 20 years (1970–1989)

Abstract

Body stalk anomaly is a severe defect of the abdominal wall with uncovered thoracic and/or abdominal organs. The umbilical cord is absent or very short. Here I present epidemiological and clinical data on 16 infants with body stalk anomaly. The 16 infants represent 3.4% of the 469 infants ascertained in an almost complete nationwide data set of live- and stillborn infants born with abdominal wall defects during the two decades 1970-1989 in Denmark. The prevalence was 0.12 per 10,000 live- and stillborn. Nine of the infants were stillbirths, seven were live births, and they all died shortly after birth. The gestational age at birth varied from 33 to 40 weeks. There was an excess of males M/F ratio: 2.2 (CI: 0.85-10.71). All infants had severe associated malformations. Among the most severe were: severe limb reduction defects (56%), absence of one kidney associated with malformations of genitalia and/or urinary bladder (62%), scoliosis (82%), and anal atresia (57%). A normal karyotype was found in all eight of the infants who were tested. There were two sets of twins; one discordant and one concordant. Mean maternal and paternal ages were 28.5 and 29.5 years, respectively, not significantly different from the mean parental ages of the Danish population during the same period.

Blastopathies and microcephaly in a Chornobyl impacted region of Ukraine

“…Both in Rivne and Denmark, investigations did not produce evidence of an OM‐twinning association (Bugge ). However, OM as a component of the OEIS complex is associated with twinning and likewise with body stalk anomalies (Bugge ). Furthermore, two investigations led by Mastroiacovo et al.…”

“…Both in Rivne and Denmark, investigations did not produce evidence of an OM-twinning association (Bugge 2010). However, OM as a component of the OEIS complex is associated with twinning and likewise with body stalk anomalies (Bugge 2012). Furthermore, two investigations led by Mastroiacovo et al (1992Mastroiacovo et al ( , 2007 and by Lee et al (1999) summarized autopsy and clinical findings of the OEIS complex with an emphasis on its association with monozygotic twinning.…”

Complex Abdominal Wall Defects: Appearances at Prenatal Imaging

“…Body stalk anomaly, also called limb body wall complex, is a rare lethal malformation with a reported prevalence of 0.12 cases per 10,000 births (including both live and still births) (45). It is characterized by attachment of visceral organs to the placenta and a short or absent umbilical cord.…”

Limb Body Wall Complex Associated with Placenta Accreta: A Mere Coincidence or a Sign of an Etiopathogenic Link?

“…Pela primeira vez, um estudo propõe a existência de uma possível possível ligação etiopatogênica entre a anomalia de limb body wall complex e os transtornos hipóxicos causados pela placentação inadequada em cicatriz uterina prévia. confirmed in 1:7,500 pregnancies; 5 however, at birth, only 0.12 cases in 10,000 6 are identified.…”