Body Size at Birth Is Associated with Food and Nutrient Intake in Adulthood

Perälä, Mia-Maria; Männistö, Satu; Kaartinen, Niina E.; Kajantie, Eero; Osmond, Clive; Barker, David J.; Valsta, Liisa; Eriksson, Johan G.

doi:10.1371/journal.pone.0046139

Cited by 59 publications

(67 citation statements)

References 39 publications

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“…In contrast, pregnant women with severe, uncontrolled diabetes or diabetic complications, such as diabetic nephropathy and/or retinopathy, are at high risk of having a microsomic fetus (i.e., a fetus with intrauterine growth restriction (IUGR)) (5,6). Such infants may be markedly small for dates; but many develop excessive weight gain and increased fat deposition in early infancy, a proxy for neonatal overnutrition (7,8). However, the long-term outcome of IUGR offspring who experience overnutrition in early life is incompletely delineated.…”

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confidence: 99%

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

et al. 2015

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Background:The aim of this study was to establish the underlying mechanisms by which a post-weaning high-fat diet (HFD) accelerates the perinatal programming of kidney injury occurring in the offspring of diabetic mothers. Methods: Male mice, offspring of nondiabetic and diabetic dams were fed with normal diet (ND) or HFD from 4 to 20 wk of age. Rat renal proximal tubular cells were used in vitro. results: On ND, the offspring of dams with severe maternal diabetes had an intrauterine growth restriction (IUGR) phenotype and developed mild hypertension and evidence of kidney injury in adulthood. Exposing the IUGR offspring to HFD resulted in rapid weight gain, catch-up growth, and later to profound kidney injury with activation of renal TGFβ1 and collagen type IV expression, increased oxidative stress, and enhanced renal lipid deposition, but not systemic hypertension. Given our data, we speculate that HFD or free fatty acids may accelerate the process of perinatal programming of kidney injury, via increased CD36 and fatty acid-binding protein 4 expression, which may target reactive oxygen species, nuclear factor-kappa B, and TGFβ1 signaling in vivo and in vitro. conclusion: Early postnatal exposure to overnutrition with a HFD increases the risk of development of kidney injury, but not hypertension, in IUGR offspring of dams with maternal diabetes.d iabetes during pregnancy, whether gestational or pregestational diabetes (type 1 or type 2), results in offspring at high risk of developing hypertension, cardiovascular disease, and chronic kidney disease in adult life. This phenomenon, termed perinatal programming, in which intrauterine events are associated with later adverse changes, has attracted much attention (1-3). Substantial epidemiologic data have also suggested that the offspring whose mothers were diabetic during pregnancy are susceptible to metabolic disturbances induced by postnatal overnutrition, as seen with high-fat diet (HFD) or with increased caloric intake in early life (1)(2)(3)(4).Women who have diabetes during pregnancy and/or are obese and hyperinsulinemic are at risk of delivering macrosomic newborns (high birth weight), and both shortand long-term outcomes of macrosomic neonates are influenced by postnatal overnutrition (1-4). In high-birth-weight neonates, subsequent growth in infancy and risk of becoming obese or diabetic are directly and linearly linked-e.g., the higher the birth weight, the greater the risk of overweight and metabolic disturbances later in life (1-4). In contrast, pregnant women with severe, uncontrolled diabetes or diabetic complications, such as diabetic nephropathy and/or retinopathy, are at high risk of having a microsomic fetus (i.e., a fetus with intrauterine growth restriction (IUGR)) (5,6). Such infants may be markedly small for dates; but many develop excessive weight gain and increased fat deposition in early infancy, a proxy for neonatal overnutrition (7,8). However, the long-term outcome of IUGR offspring who experience overnutrition in early life is incomplet...

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confidence: 99%

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

et al. 2015

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“…Five studies additionally reported other birth size measures besides birth weight (ponderal index, birth length, head circumference, or a combination of these)[14, 15, 33, 48, 49], and one study reported ponderal indices only. [59] Four articles additionally reported the effects of infant growth, besides birth weight.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies reported energy intake as only primary outcome[28, 29, 31, 33, 35, 37, 38, 61], three reported energy intake and PA level[30, 32, 34], six reported eating behavior[39–44], 17 reported only PA levels, seven reported both PA levels and SB[11, 14, 51, 52, 54, 55, 57], and one study reported only SB. [47] In 14 of the studies addressing PA and/or SB, the outcome was parent- or self-reported either by questionnaire or interview.…”

Section: Resultsmentioning

confidence: 99%

The Association of Birth Weight and Infant Growth with Energy Balance-Related Behavior – A Systematic Review and Best-Evidence Synthesis of Human Studies

et al. 2017

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BackgroundSuboptimal prenatal and early postnatal growths are associated with obesity in later life, but the underlying mechanisms are unknown. The aim of this study was to systematically review the literature that reports on the longitudinal association of (i) birth size or (ii) infant growth with later (i) energy intake, (ii) eating behaviors, (iii) physical activity or (iv) sedentary behavior in humans.MethodsA comprehensive search of MEDLINE, EMBASE, PsycINFO and The Cochrane Library was conducted to identify relevant publications. We appraised the methodological quality of the studies and synthesized the extracted data through a best-evidence synthesis.ResultsData from 41 publications were included. The quality of the studies was high in three papers, moderate in 11 and low in the large majority (n = 27) of papers appraised. Our best-evidence synthesis indicates that there is no evidence for an association of birth weight with later energy intake, eating behavior, physical activity or sedentary behavior. We found moderate evidence for an association of extreme birth weights (at both ends of the spectrum) with lower physical activity levels at a later age. Evidence for the association of infant growth with energy balance-related behavior was generally insufficient.ConclusionsWe conclude that current evidence does not support an association of early-life growth with energy balance-related behaviors in later life, except for an association of extreme birth weights with later physical activity.

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“…[78] Thus, while perinatal undernutrition itself predisposes to obesity later in life, [63,64] the addition of childhood overnutrition and sudden catch-up growth further complicates the picture. [59,72,79] Moreover, intrauterine nutritional starvation has been shown to program offsprings to preferentially consume high fat diets in animals [85,89,94] and humans, [80] which may explain the reason for the excessive catch-up growth in childhood in a nutritionally abundant environment for those exposed prenatally to starvation. Additionally, childhood obesity is associated with increased risks of adult NCCDs and adult-onset obesity (See Table 2 for details), which itself is a strong risk factor for developing NCCDs.…”

Section: Starvationmentioning

confidence: 99%

“…[69,146,147] It is thus likely that other cases of famine adversely affected the health of offsprings coming from that exposure but lack of reliable documentary data make it hard to link present day NCCDs to those earlier exposures. Besides, Africa, Asia, and other parts of the world are still [79] Low birth weight and higher catch up growth at 18 years was associated with higher BMI, blood pressure insulin resistance, LDL and triglycerides, and lower HDL at 58 years Human/ cohort study Association between body size at birth and intake of foods and macronutrients in adulthood in Helsinki birth cohort [80] Lower birth weights were associated with lower intake of fruits and berries, carbohydrates, sucrose, fructose, and Fibre, and higher intake of fat in adulthood (56-70 years)…”

Section: Starvationmentioning

confidence: 99%

The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease

Imam

Ismail

2017

Global Challenges

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There are already extensive reviews on the global burden of NCCDs in the public domain. [1][2][3][4][5][6] The consensus that can be surmised from the available data on NCCDs is that their overall prevalence appears to be rising globally and the projections indicate an upward trend. Epidemiological transition data suggests that the morbidity and mortality rate from these diseases is far more than that of communicable diseases in the developed world [7] and a similar trend is now occurring in the low to medium income countries (LMICs). [8] Among the NCCDs, cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality, followed closely by metabolic diseases like Noncommunicable chronic diseases (NCCDs) are the leading causes of morbidity and mortality globally. The mismatch between present day diets and ancestral genome is suggested to contribute to the NCCDs burden, which is promoted by traditional risk factors like unhealthy diets, physical inactivity, alcohol and tobacco. However, epigenetic evidence now suggests that cumulatively inherited epigenetic modifications may have made humans more prone to the effects of present day lifestyle factors. Perinatal starvation was widespread in the 19th century. This together with more recent events like increasing consumption of western and low fiber diets, smoking, harmful use of alcohol, physical inactivity, and environmental pollutants may have programed the human epigenome for higher NCCDs risk. In this review, on the basis of available epigenetic data it is hypothesized that transgenerational effects of lifestyle factors may be contributing to the current global burden of NCCDs. Thus, there is a need to reconsider prevention strategies so that the subsequent generations will not have to pay for our sins and those of our ancestors. Cardiovascular DiseasesDr. M. U. Imam

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Body Size at Birth Is Associated with Food and Nutrient Intake in Adulthood

Cited by 59 publications

References 39 publications

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

The Association of Birth Weight and Infant Growth with Energy Balance-Related Behavior – A Systematic Review and Best-Evidence Synthesis of Human Studies

The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease

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