Body site distribution of pediatric-onset morphea and association with extracutaneous manifestations

Chiu, Yvonne E.; Shmuylovich, Leonid; Kiguradze, Tina; Anderson, Katelyn R.; Sibbald, Cathryn; Tollefson, Megha M.; Kunzler, Elaine; Tom, Wynnis L.; Bond, Kelsie; Ahmad, Regina Celeste; García‐Romero, María Teresa; Irfan, Mahwish; Kollman, K.; Hunt, Raegan; Stein, Sarah L.; Arkin, Lisa M.; Wong, Vivian; Pope, Elena; Jacobe, Heidi; Brandling‐Bennett, Heather A.; Cordoro, Kelly M.; Bercovitch, Lionel; Rangel, Stephanie M.; Liu, Xuerong; Szabó, Anikó; Paller, Amy S.

doi:10.1016/j.jaad.2021.03.017

Cited by 9 publications

(10 citation statements)

References 18 publications

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“…Extracutaneous manifestations occur in more severe disease, indicate subdermal involvement, and warrant consideration in treatment decisions. 13,14 None of these manifestations are accounted for in the modified LoSSI, PGA-A, or MAM. When scoring the PGA-A damage domain, physicians are asked to consider musculoskeletal involvement, neurological involvement, and psychosocial impact in their global score.…”

Section: Extracutaneous Manifestationsmentioning

confidence: 99%

“…These features include constitutional symptoms, gastroesophageal reflux, active inflammatory arthritis, musculoskeletal involvement, neurological involvement, and psychosocial impairment. Extracutaneous manifestations occur in more severe disease, indicate subdermal involvement, and warrant consideration in treatment decisions . None of these manifestations are accounted for in the modified LoSSI, PGA-A, or MAM.…”

Section: Expanded Morphological Features To Accurately Capture Diseas...mentioning

confidence: 99%

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Differentiating Activity From Damage—The Morphological Challenge of Morphea

Saracino

Nikpour

2023

JAMA Dermatol

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Development of robust measures to monitor disease status and evaluate therapeutic impacts is central to improving patient outcomes. However, differentiating activity and damage in morphea is challenging. In this issue of JAMA Dermatology, García-Romero et al 1 report the development of the Morphea Activity Measure (MAM), an instrument designed to capture disease activity in pediatric morphea. Using Delphi consensus methods, 14 experts agreed on a 10-item tool. The final items were new lesions, enlarging lesions, progressive atrophy in linear lesions, erythema, violaceous rim, warmth, induration or edema, white-yellow or waxy appearance, shiny white wrinkling, and body surface area of active lesions at 7 body sites. The validity and reliability of the MAM were then tested by 8 of the original 14 experts in a cohort of 14 children with various morphea subtypes.

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Section: Extracutaneous Manifestationsmentioning

confidence: 99%

Section: Expanded Morphological Features To Accurately Capture Diseas...mentioning

confidence: 99%

Differentiating Activity From Damage—The Morphological Challenge of Morphea

Saracino

Nikpour

2023

JAMA Dermatol

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“…98 Neurologic manifestations are most frequently reported in patients with ECDS and PRS, 65,95 with neurologic manifestations more likely when lesions are located on the anterior (versus posterior) and superior (versus inferior) aspect of the head. 98 Neurologic abnormalities occur in up to 42% of these patients, most commonly seizures and migraine headaches. 22,99,100 Cranial nerve involvement and pyramidal signs have also been observed in up to 10% of patients with ECSD/PRS.…”

Section: Clinic Al Ac Tivit Y Monitoringmentioning

confidence: 99%

“…97 Musculoskeletal complications are more likely to occur when morphea involves the extensor (versus flexor) aspect of an extremity. 98 Neurologic manifestations are most frequently reported in patients with ECDS and PRS, 65,95 with neurologic manifestations more likely when lesions are located on the anterior (versus posterior) and superior (versus inferior) aspect of the head. 98 Neurologic abnormalities occur in up to 42% of these patients, most commonly seizures and migraine headaches.…”

Section: Clinic Al Ac Tivit Y Monitoringmentioning

confidence: 99%

“…Limb atrophy, joint contractures, limb length discrepancy, and gait disturbances can be seen in patients with linear morphea involving an extremity and may necessitate orthopedic intervention (Figure 7). 97 Musculoskeletal complications are more likely to occur when morphea involves the extensor (versus flexor) aspect of an extremity 98 …”

Section: Extracutaneous Manifestationsmentioning

confidence: 99%

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Pediatric morphea state‐of‐the‐art literature review: Reframing morphea as a systemic disease

Sink

Chiu

2021

Pediatric Dermatology

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Pediatric morphea is an inflammatory, fibrosing dermatologic disorder. Although morphea may be localized to the skin and subcutaneous tissues, differentiating it from systemic sclerosis, there is increasing evidence that morphea is a manifestation of a systemic inflammatory process, with the potential to involve many organ systems. Given the potential risk for irreversible sequelae, pediatric morphea should be treated early and aggressively. Long‐term disease monitoring is essential.

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Morphoea and Allied Scarring and Sclerosing Inflammatory Dermatoses

Orteu

2024

Rook's Textbook of Dermatology

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Body site distribution of pediatric-onset morphea and association with extracutaneous manifestations

Cited by 9 publications

References 18 publications

Differentiating Activity From Damage—The Morphological Challenge of Morphea

Differentiating Activity From Damage—The Morphological Challenge of Morphea

Pediatric morphea state‐of‐the‐art literature review: Reframing morphea as a systemic disease

Morphoea and Allied Scarring and Sclerosing Inflammatory Dermatoses

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