Body Plethysmographic Studies in Non-Smoking, Healthy Adults

Viljanen, A. A.; Viljanen, B. C.; Halttunen, P; Kreus, K.‐E.

doi:10.1080/00365518209168379

Cited by 17 publications

(5 citation statements)

References 4 publications

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“…Given that specific airway conductance (sGaw) is also a parameter of airflow limitation, sGaw values of < 0.12 [with or without reduced FEV 1 /(F)VC ratio] were interpreted as indicative of OLD. (17,18) Air trapping was defined as an RV > 130%, and lung hyperinflation was defined as a TLC > 120%. All patients with reduced TLC were diagnosed with restrictive lung disease.…”

Section: Methodsmentioning

confidence: 99%

Clinical and functional correlations of the difference between slow vital capacity and FVC

et al. 2020

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Objective: To evaluate the relationship that the difference between slow vital capacity (SVC) and FVC (ΔSVC-FVC) has with demographic, clinical, and pulmonary function data. Methods: This was an analytical cross-sectional study in which participants completed a respiratory health questionnaire, as well as undergoing spirometry and plethysmography. The sample was divided into two groups: ΔSVC-FVC ≥ 200 mL and ΔSVC-FVC < 200 mL. The intergroup correlations were analyzed, and binomial logistic regression analysis was performed. Results: The sample comprised 187 individuals. In the sample as a whole, the mean ΔSVC-FVC was 0.17 ± 0.14 L, and 61 individuals (32.62%) had a ΔSVC-FVC ≥ 200 mL. The use of an SVC maneuver reduced the prevalence of nonspecific lung disease and of normal spirometry results by revealing obstructive lung disease (OLD). In the final logistic regression model (adjusted for weight and body mass index > 30 kg/m2), OLD and findings of air trapping (high functional residual capacity and a low inspiratory capacity/TLC ratio) were predictors of a ΔSVC-FVC ≥ 200 mL. The chance of a bronchodilator response was found to be greater in the ΔSVC-FVC ≥ 200 mL group: for FEV1 (OR = 4.38; 95% CI: 1.45-13.26); and for FVC (OR = 3.83; 95% CI: 1.26-11.71). Conclusions: The use of an SVC maneuver appears to decrease the prevalence of nonspecific lung disease and of normal spirometry results. Individuals with a ΔSVC-FVC ≥ 200 mL, which is probably the result of OLD and air trapping, are apparently more likely to respond to bronchodilator administration.

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Section: Methodsmentioning

confidence: 99%

Clinical and functional correlations of the difference between slow vital capacity and FVC

et al. 2020

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“…Thoracic gas volume (TGV), airway resistance (Raw), and specific airway conductance (sGaw) were measured using a constant-volume body plethysmograph (Bodyscreen II; Erich Jaeger; Wurzburg, Germany) during tidal breathing timed with a metronome (30/min). 11 The mean value of three to five determinations was recorded for analysis. VC, TLC measured using body plethysmograph (TLCb), residual volume (RV), and functional residual capacity were calculated based on slow spirometric measurements and TGV measurement.…”

Section: Body Plethysmographymentioning

confidence: 99%

“…Reference values of adult Finns and European adolescents were used. 9,11 The nonventilated lung compartment was calculated as the difference between TLCb and TLCHe.…”

Section: Body Plethysmographymentioning

confidence: 99%

Restriction of lung volumes but normal function of pulmonary tissue in mulibrey nanism

Sivunen

Piirilä

Karlberg

et al. 2019

Pediatric Pulmonology

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Background: Mulibrey nanism (MUL) is a rare growth restriction disorder with multiple organ manifestations caused by genetic defects affecting the TRIM37 protein. A perimyocardial heart disease is the most serious manifestation. Many MUL children appear to suffer from airway obstruction related to infection or exercise, prompting use of inhaled therapies. Asthma medication is continued up to adolescence or even to adulthood due to persisting of symptoms. The pulmonary pathophysiology has previously not been evaluated in any MUL cohort. Methods: Thirty three finnish MUL patients (median age 20 years) were investigated with several lung function tests: spirometry with bronchodilatation test, single-breath diffusing capacity for carbon monoxide, single-breath lung volume measurements with helium dilution, and thoracic gas volume, airway resistance and specific conductance measurements with a body plethysmograph. As MUL typically affects body proportions, all variables were compared with reference values and with predicted values calculated from sitting height. Results: Total lung capacity and forced vital capacity were markedly reduced (total lung capacity [TLC] and forced vital capacity [FVC], P < .001, 51%-63% of predicted) and also forced expiratory volume in the first second was reduced (FEV1; P < .001, 47%-57%). No signs of airway obstruction was seen (normal FEV1/FVC and specific airway conductance SGaw). Diffusing capacity (DLCO) was decreased (P < .001, 60%-67%) but when related to alveolar volume it was increased (DLCO/VA, P < .001, 130%-148%). Bronchodilatation suggesting active asthma (FEV1 change ≥12% and ≥200 mL) was found only in one patient.

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“…The measured values of the dead space DS for adults and infants are taken as averages of those reported in [18,4,25,36,86,71] and [32,15,19,63,34,47,83,10], respectively. The measured values of the resistance R for adults and infants are taken as averages of those reported in [14,1,76,22,30,33,75] and [19,83,9,70,54,31,55,6,56,87,58,66,72,2], respectively. Table 4: Key physiological characteristics (dead space, DS; resistance, R; total path length L; time needed to reach saturation of oxygen in blood, T r ; and mean partial pressures, PO 2 and PCO 2 ) computed with our model for alternative airways geometries of adults and infants.…”

Section: Resultsmentioning

confidence: 99%

Impact of Airways Geometry on Transport of Gases to Blood

Saab¹,

Issa²,

Zeineddine³

et al. 2021

Preprint

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Topological structure of bronchial trees affects transport of gases and aerosols in the respiratory system. We start by providing a quantitative assessment of the alternative tree representations' ability to predict observable geometric and mechanistic characteristics, such as network resistance, dead space volume, and path length. Then we present a model of dynamic transport of oxygen and carbon dioxide along the airways, in the alveoli, across the alveolar membrane, and along the pulmonary blood capillaries. The model also accounts for the exchange of these two gases with blood in the capillaries, as well as for age, gender and other in-species characteristics. Our model's predictions are compared with corresponding observations, providing an additional venue to assess the validity of the existing representations of the lung's bronchial tree.

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Body Plethysmographic Studies in Non-Smoking, Healthy Adults

Cited by 17 publications

References 4 publications

Clinical and functional correlations of the difference between slow vital capacity and FVC

Clinical and functional correlations of the difference between slow vital capacity and FVC

Restriction of lung volumes but normal function of pulmonary tissue in mulibrey nanism

Impact of Airways Geometry on Transport of Gases to Blood

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