Body plan evolvability: The role of variability in gene regulatory networks
Alexander V. Spirov,
Ekaterina M. Myasnikova,
David M. Holloway
Abstract:Recent computational modeling of early fruit fly (Drosophila) development has characterized the degree to which gene regulation networks can be robust to natural variability. In the first few hours of development, broad spatial gradients of maternally derived transcription factors activate embryonic gap genes. These gap patterns determine the subsequent segmented insect body plan through pair-rule gene expression. Gap genes are expressed with greater spatial precision than the maternal patterns. Computational … Show more
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