Body mass index, waist-to-hip ratio and cognitive function among Chinese elderly: a cross-sectional study

Zhang, Tao; Yan, Rui; Chen, Qifeng; Ying, Xuhua; Zhai, Yujia; Li, Fudong; Wang, Xinyi; He, Fan; Ye, Chiyu; Lin, Junfen

doi:10.1136/bmjopen-2018-022055

Cited by 34 publications

(37 citation statements)

References 31 publications

(18 reference statements)

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“…The prevalence in present study was higher than older adults (60+) in Shanghai suburb (by MMSE, 7.0%) [ 30 ], and older people (65+) from 8 longevity areas of China (by MMSE, 10.0%) [ 31 ]. A survey of community-based cohort in Zhejiang Province showed that the prevalence of MCI (by MMSE) among older adults (60+) was 14.7% [ 7 ]. The prevalence of MCI among older people in previous studies was lower than that in present study.…”

Section: Discussionmentioning

confidence: 99%

“…In model 1, none covariates were included. In the literature [ 7 , 29 ], we found that age, gender, education and other confounding factors may also affect the cognition of old people. Therefore, model 2 was based on model 1, with additional adjusting for the statistically significant ( p -value< 0.05) covariates of the previous single factor analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Body mass index (BMI) is considered one of the important factors affecting cognitive function. Previous studies found that unhealthy BMI was associated with cognitive function among older adults [ 7 ]. A cross-sectional study from Malaysia concluded positive association between BMI and cognitive function, measured by Mini-Mental State Examination (MMSE) in older adults aged 60 years and above [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Body mass index and mild cognitive impairment among rural older adults in China: the moderating roles of gender and age

Yuan

Zhang

et al. 2021

BMC Psychiatry

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Background Evidence concerning the association between body mass index (BMI) and cognitive function among older people is inconsistent. This study aimed to investigate gender and age as moderators in association between BMI and mild cognitive impairment (MCI) among rural older adults. Methods Data were derived from the 2019 Health Service for Rural Elderly Families Survey in Shandong, China. In total, 3242 people aged 60 years and above were included in the analysis. Multilevel mixed-effects logistic regression was used to examine the moderating roles of gender and age, then further to explore the relationship between BMI and MCI. Results There were 601 (18.5%) participants with MCI. Compared with normal BMI group, low BMI group had a higher risk of MCI among older people [adjusted odds ratio (aOR) = 2.08, 95% confidence interval (CI): 1.26–3.44], women (aOR = 2.06, 95% CI: 1.35–3.12), or the older elderly aged ≥75 years old (aOR = 3.20, 95% CI: 1.34–7.45). This effect remained statistically significant among older women (aOR = 3.38, 95% CI: 1.69–6.73). Among older men, elevated BMI group had a higher risk of MCI (aOR = 2.32, 95% CI: 1.17–4.61) than normal BMI group. Conclusions Gender and age moderated the association between BMI and MCI among Chinese rural older adults. Older women with low BMI were more likely to have MCI, but older men with elevated BMI were more likely to have MCI. These findings suggest rural community managers strengthen the health management by grouping the weight of older people to prevent the risk of dementia.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Body mass index and mild cognitive impairment among rural older adults in China: the moderating roles of gender and age

Yuan

Zhang

et al. 2021

BMC Psychiatry

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“…Many studies have shown that physical activities can help to preserve cognitive health in old age (Flicker et al, 2011; Najar et al, 2019). Furthermore, increasing evidences reveal a relationship between obesity and cognitive impairment (Cifre et al, 2018; Zhang et al, 2018). In this study, BMI was found to be a risk factor in cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Dietary Intake of Riboflavin and Unsaturated Fatty Acid Can Improve the Multi-Domain Cognitive Function in Middle-Aged and Elderly Populations: A 2-Year Prospective Cohort Study

Tao

Chen

et al. 2019

Front. Aging Neurosci.

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Objective This study was aimed to explore the effects of dietary nutrients on cognitive function among the middle-aged and elderly populations. Methods A prospective cohort study of 1,385 middle-aged and elderly people was conducted from January 2014 to December 2017. Dietary nutrients were assessed according to the food frequency questionnaire (FFQ) and China Food Composition Database (CFCD). Montreal cognitive assessment (MoCA) was used to evaluate the participants’ global cognitive function. Six other neuropsychological measures [auditory verbal learning test-immediate recall (AVLT-IR), auditory verbal learning test-short recall (AVLT-SR), auditory verbal learning test-long recall (AVLT-LR), logical memory test (LMT), digit span forward (DST-F), and digit span backward (DST-B)] were used to assess the verbal memory domain and the attention domain by principal component analysis (PCA). Multiple linear regressions were conducted to explore associations between nutrients and cognition. Sensitivity analyses were performed to confirm the results. Results Dietary riboflavin was protective for global cognitive function (β = 1.31, 95% CI: 0.26, 2.35) and the verbal memory domain (β = 0.37, 95% CI: 0.02, 0.71). Unsaturated fatty acid (USFA) played a protective role in global cognitive function (β = 1.15, 95% CI: 0.16, 2.14). The protective effects of riboflavin and USFA on cognitive function were consistent and reliable when different confounders were adjusted during sensitivity analyses. During the follow-up, neuropsychological measure scores revealed a reduced decline in the high-riboflavin group (d-MoCA, P = 0.025; d-AVLT-IR, P = 0.001; d-DST-B, P = 0.004; and d-composite score, P = 0.004) and the high-USFA group (d-AVLT-IR, P = 0.007; d-LMT, P = 0.032; d-DST-B, P = 0.002; and d-composite score, P = 0.008). Conclusion Higher intake of riboflavin and USFA can improve multi-dimensional cognitive functioning in middle-aged and elderly people. These findings were consistent in different models of sensitivity analyses.

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“…Data was obtained from a public health surveillance project aimed at exploring health problems among elderly people in Zhejiang [ 24 ]. The project was conducted in all 11 cities in Zhejiang since 2014, and each city chose at least one county to recruit a minimum of 1000 permanent residents aged 60 years and older.…”

Section: Methodsmentioning

confidence: 99%

Does aluminum exposure affect cognitive function? a comparative cross-sectional study

Zhang

Lin

et al. 2021

PLoS ONE

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Objectives This study assessed the cognitive function of aluminum-exposed participants from an alum mining zone, compared them with unexposed subjects, and aimed to elucidate the effect of aluminum exposure on cognition. Design This was a comparative cross-sectional study. Univariate analyses were used to assess the differences between the aluminum-exposed and unexposed groups. Binary logistic regression models were applied to analyze the effect of aluminum exposure. Setting The aluminum-exposed participants were included from an alum mining zone and the unexposed subjects were residents from another district without alum-mine-related factories. Participants We included 539 aluminum-exposed participants (254 men, 285 women) and 1720 unexposed participants (692 men, 1028 women). Results The mean cognition score on Mini-Mental State Examination was 21.34 (± 6.81) for aluminum-exposed participants. The exposed group had 6.77 times (95% confidence interval, 5.09–9.00) more risk of cognitive impairment than the unexposed group, after adjusting for age, sex, and educational level. No statistically significant association was found between exposure duration and cognition. Conclusions This study demonstrated a significant association between aluminum exposure and lower cognitive function.

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Body mass index, waist-to-hip ratio and cognitive function among Chinese elderly: a cross-sectional study

Cited by 34 publications

References 31 publications

Body mass index and mild cognitive impairment among rural older adults in China: the moderating roles of gender and age

Body mass index and mild cognitive impairment among rural older adults in China: the moderating roles of gender and age

Dietary Intake of Riboflavin and Unsaturated Fatty Acid Can Improve the Multi-Domain Cognitive Function in Middle-Aged and Elderly Populations: A 2-Year Prospective Cohort Study

Does aluminum exposure affect cognitive function? a comparative cross-sectional study

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