Body mass index, serum total cholesterol, and risk of gastric high-grade dysplasia

Huang, Yakai; Kang, Weiming; Ma, Zhiqiang; Liu, Yuqin; Zhou, Li; Yu, Jian-chun

doi:10.1097/md.0000000000004730

Cited by 13 publications

(9 citation statements)

References 67 publications

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“…Chronic gastritis then can convert into gastric atrophy, intestinal metaplasia and dysplasia, and finally transformed into GC . Previous studies reported that overweight and obesity were associated with dysplasia and intestinal metaplasia, and it is possible that the pro‐inflammatory effects of obesity may then contribute to the progression of these inflammatory states toward cancer. Other studies found associations between underweight and intestinal metaplasia and an inverse relationship between BMI and atrophic gastritis, whereby low BMI may then be reflecting malabsorption from the condition of severe gastritis .…”

Section: Discussionmentioning

confidence: 99%

The U‐shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case–control study from eight East Asian cohort studies

Jang

Wang

Cai

et al. 2019

Intl Journal of Cancer

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The association between body mass index (BMI) and noncardia gastric cancer (NCGC) risk remains controversial. The purpose of our study was to examine the association of BMI with NCGC risk with consideration of Helicobacter pylori (HP) biomarkers. This international nested case-control study, composed of 1,591 incident NCGC cases and 1,953 matched controls, was established from eight cohorts in China, Japan and Korea, where the majority of NCGCs are diagnosed worldwide. HP antibody biomarkers were measured in blood collected at cohort enrollment by multiplex serology. The NCGC risk according to baseline BMI was estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CIs). We found a U-shaped association between BMI category and NCGC risk. Compared to those with reference BMI (22.6-25.0 kg/m 2 ), those with lower and higher BMI had an increased NCGC risk (BMI <18.5 kg/m 2 , OR = 1.56, 95% CI = 1.04-2.34; BMI >27.5 kg/m 2 , OR = 1.48, 95% CI = 1.15-1.91; adjusted for age, sex and smoking). The U-shaped association was persistent among subjects with HP infection and high-risk biomarkers (HP+ CagA+: BMI <18.5 kg/m 2 , OR = 1.60, 95% CI = 1.00-2.55; BMI >27.5 kg/m 2 , OR = 1.59, 95% CI = 1.21-2.11; and Omp+ HP0305+: BMI <18.5 kg/m 2 , OR = 1.88, 95% CI = 1.04-3.42; BMI >27.5 kg/m 2 , OR = 1.70, 95% CI = 1.20-2.42, respectively). Our study provides evidence of significantly increased NCGC risk among individuals with low or high BMI, including in subjects with high-risk HP biomarkers (HP+ CagA+, Omp+ HP0305+) in the high-risk area of East Asia.Additional Supporting Information may be found in the online version of this article. What's new?Gastric-cancer (GC) mortality in East Asian countries accounts for 58% of GC deaths worldwide. Does body mass index (BMI) affect GC risk in these populations? In this prospective study, the authors found a U-shaped association between BMI and noncardia GC risk. This association also held true for subjects with high-risk biomarkers for Helicobacter pylori infection. These results indicate that maintaining normal body weight is important for reducing gastric-cancer risk in East Asia, which may help guide public health strategies.

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Section: Discussionmentioning

confidence: 99%

The U‐shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case–control study from eight East Asian cohort studies

Jang

Wang

Cai

et al. 2019

Intl Journal of Cancer

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“…There are also reports which show a positive association of high blood cholesterol with an increased risk of gastric cancer. The risk of gastric dysplasia (pre-cancerous lesion which is often considered as a penultimate stage of gastric cancer) was increased in patients with elevated blood cholesterol levels [149 , 150] . Earlier studies from Pih GY, et al.…”

Section: Role Of Cholesterol In Various Cancermentioning

confidence: 99%

Influence of cholesterol on cancer progression and therapy

Mayengbam

Singh

Pillai

et al. 2021

Translational Oncology

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Highlights Abnormality in blood cholesterol level is significantly correlated with risk of different cancers. Majority of tumor tissue from cancer patient exhibits overexpression of LDLR and ACAT for supporting rapid cancer cell proliferation. Alteration of the cholesterol metabolism in cancer cells hampers therapeutic response. Targeting cholesterol metabolism for treatment of cancer with other conventional chemotherapeutic drugs appears to be beneficial.

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“…However, previous studies have shown contradictory results about the effect of lipids on various cancers, including gastric cancer. TC had negative [ 4 , 5 ], positive [ 6 ], or no correlation [ 7 ] with gastric neoplasms. In addition, few studies have focused on the relationships of TG, LDL-C, or apolipoproteins with gastric cancer, as most reports have been based on ancillary findings observed in a study of metabolic syndrome or statins.…”

Section: Introductionmentioning

confidence: 99%

Associations of Serum Lipid Level with Gastric Cancer Risk, Pathology, and Prognosis

et al. 2021

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Purpose The association of serum lipids with gastric cancer is controversial. We clarified the role of serum lipids in the development, progression, and prognosis of gastric cancer.Materials and Methods In total, 412 patients diagnosed with gastric cancer were prospectively recruited, and 2,934 control subjects who underwent screening endoscopy were enrolled from December 2013 to March 2017 to conduct a case-control study in a tertiary center. Serum lipid profiles, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-I (apoA-I), and apolipoprotein B, and clinicopathologic characteristics were analyzed.Results The gastric cancer group showed significantly lower HDL-C, higher LDL-C, and lower apoA-I level than the control group. In multivariate analysis, old age (odds ratio [OR], 1.051; p < 0.001), smoking (OR, 1.337; p < 0.001), a family history of gastric cancer (OR, 2.038; p < 0.001), Helicobacter pylori seropositivity (OR, 4.240; p < 0.001), lower HDL-C (OR, 0.712; p=0.020), and higher LDL-C (p=0.002) were significant risk factors for gastric cancer. Lower HDL-C and higher LDL-C remained significant after adjustments for covariates, including age and sex. In a subgroup analysis of the gastric cancer group, lower TG levels were associated with undifferentiated histology. No serum lipids were associated with overall survival.Conclusion Lower HDL-C and higher LDL-C were associated with the risk of gastric cancer, even after adjusting for age, sex, and other factors. In the gastric cancer group, undifferentiated histology was associated with lower TG levels.

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Body mass index, serum total cholesterol, and risk of gastric high-grade dysplasia

Abstract: Supplemental Digital Content is available in the text

Cited by 13 publications

References 67 publications

The U‐shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case–control study from eight East Asian cohort studies

The U‐shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case–control study from eight East Asian cohort studies

Influence of cholesterol on cancer progression and therapy

Associations of Serum Lipid Level with Gastric Cancer Risk, Pathology, and Prognosis

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