Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer

Fayanju, Oluwadamilola M.; Hall, Carolyn; Bauldry, Jessica B.; Karhade, Mandar; Valad, Lily M.; Kuerer, Henry Mark; DeSnyder, Sarah M.; Barcenas, Carlos H.; Lucci, Anthony

doi:10.1016/j.amjsurg.2017.06.005

Cited by 10 publications

(8 citation statements)

References 33 publications

(31 reference statements)

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“…No association was seen between CTC counts and clinicopathological details apart from BMI and pre-treatment CTC counts. BMI has been shown to mediate the prognostic significance of CTCs in inflammatory breast cancer [30]. In a recent publication, patient-derived xenograft (PDX) model, tumours grown in the presence of obesity-altered adipose stem cells in SCID/beige mice had increased circulating HLA1 + human cells as well as increased numbers of CD44 + CD24 − cancer stem cells in the peripheral blood, the authors concluded leptin produced by obesity-altered adipose stem cells promotes metastasis.…”

Section: Discussionmentioning

confidence: 99%

Circulating tumour cell enumeration does not correlate with Miller–Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy

O’Toole

Spillane

Huang

et al. 2020

Breast Cancer Res Treat

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Purpose The association between pathological complete response (pCR) in patients receiving neoadjuvant chemotherapy (NAC) for breast cancer and Circulating Tumour Cells (CTCs) is not clear. The aim of this study was to assess whether CTC enumeration could be used to predict pathological response to NAC in breast cancer as measured by the Miller-Payne grading system. Methods Twenty-six patients were recruited, and blood samples were taken pre-and post-NAC. CTCs were isolated using the ScreenCell device and stained using a modified Giemsa stain. CTCs were enumerated by 2 pathologists and classified as single CTCs, doublets, clusters/microemboli and correlated with the pathological response as measured by the Miller-Payne grading system. χ 2 or ANOVA was performed in SPSS 24.0 statistics software for associations. Results 89% of patients had invasive ductal carcinoma (IDC) and 11% invasive lobular carcinoma (ILC). At baseline 85% of patients had CTCs present, median 7 (0-161) CTCs per 3 ml of whole blood. Post-chemotherapy, 58% had an increase in CTCs. This did not correlate with the Miller-Payne grade of response. No significant association was identified between the number of CTCs and clinical characteristics; however, we did observe a correlation between pre-treatment CTC counts and body mass index, p < 0.05. Conclusions Patients with a complete response to NAC still had CTCs present, suggesting enumeration is not sufficient to aid surgery stratification. Additional characterisation and larger studies are needed to further characterise CTCs isolated pre-and post-chemotherapy. Long-term follow-up of these patients will determine the significance of CTCs in NAC breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Circulating tumour cell enumeration does not correlate with Miller–Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy

O’Toole

Spillane

Huang

et al. 2020

Breast Cancer Res Treat

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“…The association between BMI and CTC level is not widely described, however studies on breast cancer patients show inconsistent results. Ortmann et al found no significant relation, neither before, nor after, chemotherapy, between BMI and CTC number, suggesting they are independent prognostic factors [80], while Fayanju et al indicated negative prognostic significance of their combination for non-obese patients exclusively [81].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays

Budna‐Tukan

Świerczewska

Mazel³

et al. 2019

Cancers

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The characterization of circulating tumor cells (CTCs) can lead to a promising strategy for monitoring residual or relapsing prostate cancer (PCa) after local therapy. The aim of this study was to compare three innovative technologies for CTC enumeration in 131 high-risk patients with PCa, before and after radiotherapy, combined with androgen deprivation. The CTC number was tested using the FDA-cleared CellSearch® system, the dual fluoro-EPISPOT assay that only detects functional CTCs, and the in vivo CellCollector® technology. The highest percentage of CTC-positive patients was detected with the CellCollector® (48%) and dual fluoro-EPISPOT (42%) assays, while the CellSearch® system presented the lowest rate (14%). Although the concordance among methods was only 23%, the cumulative positivity rate was 79%. A matched-pair analysis of the samples before, and after, treatment suggested a trend toward a decrease in CTC count after treatment with all methods. CTC tended to be positivity correlated with age for the fluoro-EPISPOT assay and with PSA level from the data of three assays. Combining different CTC assays improved CTC detection rates in patients with non-metastatic high-risk PCa before and after treatment. Our findings do not support the hypothesis that radiotherapy leads to cancer cell release in the circulation.

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“…Epidemiological studies have shown that education [9] and race [10,11] are independent predictors of BMI [9]. High BMI may mediate some of the inequalities and disparities in health [12,13,14,15,16,17,18,19,20,21,22,23]. Finally, race, ethnicity, and economic factors have some separate, additive, or multiplicative effects [9].…”

Section: Introductionmentioning

confidence: 99%

Unequal Protective Effects of Parental Educational Attainment on the Body Mass Index of Black and White Youth

Assari

Boyce

Bazargan

et al. 2019

IJERPH

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Background: Parental educational attainment is shown to be protective against health problems; the Minorities’ Diminished Returns theory, however, posits that these protective effects tend to be smaller for socially marginalized groups particularly blacks than whites. Aims: To explore racial differences in the effect of parental educational attainment on body mass index (BMI) in a national sample of US adolescents. Methods: In this cross-sectional study, we used baseline data of 10,701 (8678 white and 2023 black) 12–17 years old adolescents in the Population Assessment of Tobacco and Health (PATH; 2013). Parental educational attainment was the predictor. Youth BMI (based on self-reported weight and height) was the dependent variable. Age, gender, ethnicity, and family structure were covariates. Race was the focal moderator. Results: Overall, higher parental educational attainment was associated with lower youth BMI. Race, however, moderated the effect of parental educational attainment on BMI, suggesting that the protective effect of parental educational attainment on BMI is significantly smaller for black than white youth. Conclusions: In the United States, race alters the health gains that are expected to follow parental educational attainment. While white youth who are from highly educated families are fit, black youth have high BMI at all levels of parental educational attainment. This means, while the most socially privileged group, whites, gain the most health from their parental education, blacks, the least privileged group, gain the least. Economic, social, public, and health policymakers should be aware that health disparities are not all due to lower socioeconomic status (SES) of the disadvantaged group but also diminished returns of SES resources for them. Black–white health disparities exist across all high socioeconomic status (SES) levels.

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Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer

Cited by 10 publications

References 33 publications

Circulating tumour cell enumeration does not correlate with Miller–Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy

Circulating tumour cell enumeration does not correlate with Miller–Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy

Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays

Unequal Protective Effects of Parental Educational Attainment on the Body Mass Index of Black and White Youth

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