Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal cohort study

Miyake, Teruki; Kumagi, Teru; Hirooka, Masashi; Furukawa, Shinya; Koizumi, Masaru; Terada, Yoshio; Ueda, T.; Yamamoto, Shin; Abe, Masanori; Kitai, Kohichiro; Hiasa, Yoichi; Matsuura, Bunzo; Onji, Morikazu

doi:10.1007/s00535-012-0650-8

Cited by 75 publications

(66 citation statements)

References 29 publications

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“…Although total body adiposity remains a risk factor for type-2-diabetes, 1 dyslipidemia, 2 cardiovascular disease (CVD) 3 and non-alcoholic fatty liver disease (NAFLD), 4 adipose tissue distribution appears to be a more robust predictor of obesityrelated disease risk. Visceral adipose tissue located among various organs including the liver in the intra-abdominal cavity is associated with type-2-diabetes, [5][6][7][8][9] dyslipidemia, [10][11][12] inflammation, increased risk of thrombosis [13][14][15] and NAFLD.…”

Section: Introductionmentioning

confidence: 99%

The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD

et al. 2015

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Section: Introductionmentioning

confidence: 99%

The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD

et al. 2015

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“…N onalcoholic fatty liver disease is becoming more common worldwide, possibly because of the increasing incidence of human obesity (24). Nonalcoholic steatohepatitis (NASH) is closely associated with the metabolic complications as a result of overnutrition, including obesity and insulin resistance (22).…”

Section: Introductionmentioning

confidence: 99%

RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

Han

Kim

et al. 2014

Antioxidants & Redox Signaling

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Aims: Increased hepatic oxidative stress and inflammation is the main cause of exacerbating nonalcoholic steatohepatitis (NASH). Retinoic acid-related orphan receptor a (RORa) regulates diverse target genes associated with lipid metabolism, and its expression level is low in the liver of patients with NASH. Here, we investigated the role of RORa in regulating hepatic oxidative stress and inflammation. Results: First, cholesterol sulfate (CS), an agonist of RORa, lowered oxidative stress that was induced by 1.5 mM oleic acid in the primary cultures of hepatocytes. Second, exogenously introduced RORa or CS treatment induced the mRNA level of antioxidant enzymes, superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPx1), through the RORa response elements located in the upstream promoters of Sod2 and Gpx1. Third, RORa significantly decreased reactive oxygen species levels and mRNA levels of tumor necrosis factor a (TNFa) and interleukin-1b that were induced by lipopolysaccharide or TNFa in Kupffer cells. Finally, the administration of JC1-40 decreased the signs of liver injury, lipid peroxidation, and inflammation in the MCD diet-induced NASH mice. Innovation and Conclusion: We showed for the first time that RORa and its ligands protect NASH in mice by reducing hepatic oxidative stress and inflammation. Further, the molecular mechanism of the protective function of RORa against oxidative stress in the liver was revealed. These findings may offer a rationale for developing therapeutic strategies against NASH using RORa ligands.

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“…The study enrolled 3215 subjects (882 men and 2333 women) and analyzed the individuals after an observation period of 1208 days. 23 Multivariate analyses confirmed that BMI, at baseline, was the most useful factor for predicting NAFLD onset in both sexes (men: OR 1.223; 95% CI 1.138-1.318; P < 0.001; women: OR 1.331; 95% CI 1.263-1.404; P < 0.001) ( ALT, alanine aminotransferase; BMI, body mass index; CI, confidence interval; HbA1c, hemoglobin A1c; HDL-c, high-density lipoprotein-cholesterol; IR, insulin resistance; NAFLD, non-alcoholic fatty liver disease; OR, odds ratio; TG, triglyceride; UA, uric acid.…”

Section: Body Mass Indexmentioning

confidence: 99%

Non‐alcoholic fatty liver disease: Factors associated with its presence and onset

Miyake

Kumagi

Furukawa

et al. 2013

J of Gastro and Hepatol

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Non-alcoholic fatty liver disease (NAFLD) may progress to cirrhosis, liver failure, and complicated hepatocellular carcinoma. In addition, NAFLD is a risk factor for the development of other serious diseases, such as diabetes or cardiovascular disease. Therefore, the detection of early-stage NAFLD is important. Many studies have described the factors that predict the presence of NAFLD and its onset, and several markers have been identified. These markers have enabled the identification of high-risk patients and have improved routine medical practice. To prevent advanced disease, clinicians need to have simple markers that predict the onset of NAFLD so that interventions can be started at much earlier stages of disease. This review summarizes the current state of knowledge regarding independent factors, as reported in large studies, that predict the presence of NAFLD and its onset, especially markers that can be used in daily medical practice, such as physical measurements and blood tests.

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Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal cohort study

Cited by 75 publications

References 29 publications

The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD

The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD

RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

Non‐alcoholic fatty liver disease: Factors associated with its presence and onset

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