Body mass index is related to autonomic nervous system activity as measured by heart rate variability — A replication using short term measurements

Koenig, Julian; Jarczok, Marc N.; Warth, Marco; Ellis, Robert J.; Bach, Claudia; Hillecke, Thomas K.; Thayer, Julian F.

doi:10.1007/s12603-014-0022-6

Cited by 141 publications

(92 citation statements)

References 9 publications

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“…A final limitation is that extrinsic influences on infants' vagal regulation were not examined. Measures of autonomic functioning have been linked to body mass index in adults (Koenig et al, 2014) and time of day in children (Massin, Maeyns, Withofs, Ravet, & Gérard, 2000), and could have impacted RSA values in this study. Prior exposure to screens in particular could have influenced infants' vagal regulation during the video task.…”

Section: Discussionmentioning

confidence: 97%

Cardiac vagal regulation in infancy predicts executive function and social competence in preschool: Indirect effects through language

Whedon

Perry

Calkins

et al. 2018

Developmental Psychobiology

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Parasympathetic nervous system functioning in infancy may serve a foundational role in the development of cognitive and socioemotional skills (Calkins, 2007). In this study (N = 297), we investigated the potential indirect effects of cardiac vagal regulation in infancy on children's executive functioning and social competence in preschool via expressive and receptive language in toddlerhood. Vagal regulation was assessed at 10 months during two attention conditions (social, nonsocial) via task-related changes in respiratory sinus arrhythmia (RSA). A path analysis revealed that decreased RSA from baseline in the nonsocial condition and increased RSA in the social condition were related to larger vocabularies in toddlerhood. Additionally, children's vocabulary sizes were positively related to their executive function and social competence in preschool. Indirect effects from vagal regulation in both contexts to both 4-year outcomes were significant, suggesting that early advances in language may represent a mechanism through which biological functioning in infancy impacts social and cognitive functioning in childhood.

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Section: Discussionmentioning

confidence: 97%

Cardiac vagal regulation in infancy predicts executive function and social competence in preschool: Indirect effects through language

Whedon

Perry

Calkins

et al. 2018

Developmental Psychobiology

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“…It is also important to acknowledge some limitations of our study. There are potential confounding factors that we did not control for here including physical activity (Rennie et al, 2003; Soares-Miranda et al, 2014), smoking status (Sjoberg and Saint, 2011; Harte and Meston, 2014), alcohol use (Quintana et al, 2013a,b), body mass index (Britton et al, 2007; Koenig et al, 2014), and biomarkers including fasting glucose (Stein et al, 2007) and cholesterol (Britton et al, 2007; Thayer and Fischer, 2013), all of which may impact on heart rate parameters. We refer interested readers to a recent review of the various issues that researchers should consider when collecting measures of HRV (Quintana and Heathers, 2014).…”

Section: Discussionmentioning

confidence: 99%

Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality

et al. 2014

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Background: Major depressive disorder (MDD) is associated with increased heart rate and reductions in its variability (heart rate variability, HRV) – markers of future morbidity and mortality – yet prior studies have reported contradictory effects. We hypothesized that increases in heart rate and reductions in HRV would be more robust in melancholia relative to controls, than in patients with non-melancholia.Methods: A total of 72 patients with a primary diagnosis of MDD (age M: 36.26, SE: 1.34; 42 females) and 94 controls (age M: 35.69, SE: 1.16; 52 females) were included in this study. Heart rate and measures of its variability (HRV) were calculated from two 2-min electrocardiogram recordings during resting state. Propensity score matching controlled imbalance on potential confounds between patients with melancholia (n = 40) and non-melancholia (n = 32) including age, gender, disorder severity, and comorbid anxiety disorders.Results: MDD patients with melancholia displayed significantly increased heart rate and lower resting-state HRV (including the square root of the mean squared differences between successive N–N intervals, the absolute power of high frequency and standard deviation of the Poincaré plot perpendicular to the line of identity measures of HRV) relative to controls, findings associated with a moderate effect size (Cohens d’s = 0.56–0.58). Patients with melancholia also displayed an increased heart rate relative to those with non-melancholia (Cohen’s d = 0.20).Conclusion: MDD patients with melancholia – but not non-melancholia – display robust increases in heart rate and decreases in HRV. These findings may underpin a variety of behavioral impairments in patients with melancholia including somatic symptoms, cognitive impairment, reduced responsiveness to the environment, and over the longer-term, morbidity and mortality.

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“…This model was programmed in two blocks/steps: (a) the first block included and set the covariates: patient’s age, BMI (since it has been reported that HRV is related to BMI; Koenig et al, 2014, 2015), SCL-90R depression and the ED subtype; and (b) the second block added anxiety and HRV measures. Goodness-of-fit was measured with the Hosmer–Lemeshow test ( p > 0.05 was considered adequate fitting), the global predictive capacity with the Nagelkerke’s pseudo- R 2 coefficient (the adjusted contribution of the predictors was calculated as the increase between blocks 1 and 2, Δ R 2 ) and the global discriminative capacity with the area under the ROC curve (AUC).…”

Section: Methodsmentioning

confidence: 99%

Non-suicidal Self-Injury in Eating Disordered Patients: Associations with Heart Rate Variability and State-Trait Anxiety

et al. 2017

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Background: Non-suicidal self-injury (NSSI) is commonly present in individuals with eating disorders (EDs) and is often employed as a maladaptive emotion regulation strategy to avoid or abate negative emotions. One of the most prevalent negative emotions experienced by self-injurers is anxiety; however, this emotion has not been extensively studied in this population. Thus, the aim of our study was to investigate the influence of anxiety on NSSI in patients with ED from two different dimensions: state anxiety and trait anxiety.Methods: The study comprised a total of 66 females: 12 ED patients with NSSI, 32 ED patients without a history of NSSI, and 22 healthy controls. State and trait anxiety were assessed by means of State-Trait Anxiety Inventory (STAI-S-T) and physiological data [i.e., heart rate variability (HRV)] were collected.Results: STAI-trait scores were significantly higher in ED patients with NSSI than ED patients without NSSI. Furthermore, when conducting logistic regression analyses higher STAI-trait scores were associated with NSSI in ED patients. However, no differences in STAI-state scores and HRV were found between ED patients with and without NSSI.Discussion: The present findings suggest that anxiety as a trait is associated with the use of maladaptive strategies (i.e., NSSI) in ED patients. These results uphold the need to target trait anxiety in ED treatment in order to prevent possible NSSI behaviors.

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Body mass index is related to autonomic nervous system activity as measured by heart rate variability — A replication using short term measurements

Cited by 141 publications

References 9 publications

Cardiac vagal regulation in infancy predicts executive function and social competence in preschool: Indirect effects through language

Cardiac vagal regulation in infancy predicts executive function and social competence in preschool: Indirect effects through language

Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality

Non-suicidal Self-Injury in Eating Disordered Patients: Associations with Heart Rate Variability and State-Trait Anxiety

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