Body mass index is not associated with donor oocyte recipient success: an ideal study using a paired analysis of sibling-oocytes

Setton, Robert; Chung, Alice; Zimmerman, Lilli D.; Melnick, A.P.; Rosenwaks, Zev; Spandorfer, Steven D.

doi:10.1016/j.xfre.2020.05.001

Cited by 5 publications

(4 citation statements)

References 30 publications

(23 reference statements)

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“…We compared 71 pairs of donor oocyte recipients, in which one recipient was normalweight and the other was obese, who received "sibling oocytes" (oocytes from a donor that were retrieved from a single controlled ovarian hyperstimulation cycle and split between the two patients). We observed similar implantation rates and live birth rates between the patient pairs suggesting that obesity does not adversely affect endometrial receptivity [24].…”

Section: Discussionsupporting

confidence: 59%

Live birth outcomes in infertile patients with class III and class IV obesity following fresh embryo transfer

Romanski

Bortoletto

Magaoay

et al. 2020

J Assist Reprod Genet

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Objective Assess the effect of class III (body mass index [BMI, kg/m 2 ] 40-49.9) and class IV obesity (≥ 50) on clinical pregnancy and live birth outcomes after first oocyte retrieval and fresh embryo transfer cycle. Design Cohort study Setting Academic center Patients Patients undergoing their first oocyte retrieval with planned fresh embryo transfer in our clinic between 01/01/2012 and 12/31/2018. Patients were stratified by BMI: 18.5-24.9 (n = 4913), 25-29.9 (n = 1566) 30-34.9 (n = 559), 35-39.9 (n = 218), and ≥ 40 (n = 114). Intervention None Main outcome measure Live birth rate Results Following embryo transfer, there were no differences in pregnancy rates across all BMI groups (p value, linear trend = 0.86). However among pregnant patients, as BMI increased, a significant trend of a decreased live birth rate was observed (p value, test for linear trend = 0.004). Additionally, as BMI increased, a significant trend of an increased miscarriage rate was observed (p value, linear trend = < 0.001). Compared to the normal-weight cohort, women with a BMI ≥ 40 had a significantly higher rate of cancelled fresh transfers after retrieval (18.4% vs. 8.2%, OR 2.51; 95%CI 1.55-4.08). Among singleton deliveries, a significant trend of an increased c-section rate was identified as the BMI increased (p value, linear trend = <0.001). Conclusion Overall, patients with a BMI > 40 have worse IVF treatment outcomes compared to normal-weight patients. After embryo transfer, their pregnancy rate is comparable to normal-weight women; however, their miscarriage rate is higher, leading to a lower live birth rate for pregnant women in this population. Patients with a BMI > 40 have a c-section rate that is 50% higher than normal-weight patients.

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Section: Discussionsupporting

confidence: 59%

Live birth outcomes in infertile patients with class III and class IV obesity following fresh embryo transfer

Romanski

Bortoletto

Magaoay

et al. 2020

J Assist Reprod Genet

Self Cite

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“…Body mass index has no effect on donor oocyte recipient achievement [26]. In gestational carriers, CPR, LPR, and MR were not considerably different throughout the BMI categories [27].…”

Section: Impact Of Obesity On the Success Of Ivfmentioning

confidence: 99%

Update on obesity and assisted reproductive technology

Elnashar

2023

Middle East Fertil Soc J

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Background The effect of obesity on IVF consequences is still debatable. Main body Obesity is linked to a greater likelihood of maternal and fetal complications all through gestation, including miscarriage, premature births, fetal demise, and adverse pregnancy outcomes. There was no increase in chromosomal abnormality percentages with increasing body mass index (BMI), implying that poor oocyte “performance” in obese patients could be caused by variables other than chromosomal expertise. Ribonucleic acid (RNA)-sequence research showed molecular changes in the oocytes of obese patients. Each 5-unit rise in female BMI is attributed with both a 5% and 7% reduction in hazard for CPR and LBR, in both, and a 9% rise in the comparative chance of miscarriage. There is no clinical or moral mandate for establishing a societal BMI limit for rejecting a client or couple direct exposure to infertility treatment. Assessment with an interdisciplinary approach prior to an IVF treatment should be done to assess the safety of oocyte retrieval under anesthesia, taking into account variables including body mass index and comorbid conditions. On LBR, there is no convincing evidence of the significance of lifestyle modification for losing weight. There is contradictory information on the impacts of weight loss surgery on pregnancy outcomes. IVF success rate was unaffected by weight loss surgery. Conclusion Obesity has been linked to anovulation, decreased ovarian response to ovulatory prescription medications, changed oocyte and endometrial activity, an elevated risk of fertility problems, and reduced rates of live birth following IVF.

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“…16 In a more recent study published in 2020, the authors used a unique shared donor oocyte model to evaluate whether women with discrepant BMIs who received sister oocytes from the same donor oocyte cycle had similar outcomes and found that a higher BMI did not increase miscarriage rates. 17…”

Section: Oocytementioning

confidence: 99%

Obesity and Miscarriage

McLean,

Boots

2023

Semin Reprod Med

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Obesity affects nearly 40% of reproductive-aged women and has serious implications for women's overall and reproductive health. Women with an elevated body mass index (BMI) have higher rates of anovulation and irregular menses, lower success with fertility treatment, and significantly higher rates of pregnancy complications, such as hypertension/preeclampsia, gestational diabetes, and preterm delivery. Many studies have also shown an association between obesity and early pregnancy loss. However, the causal association between BMI and miscarriage has not been elucidated, likely due to the multifactorial effects that BMI may have on early pregnancy development. In addition, BMI as an isolated variable fails to capture other relevant confounding health risk factors, such as nutrition, physical activity, and insulin resistance. In this review, we will summarize the current literature demonstrating the association between BMI and miscarriage, highlight the research that attempts to explain the association, and finally provide data on therapeutic interventions to improve reproductive outcomes in women suffering from obesity and early pregnancy loss.

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Body mass index is not associated with donor oocyte recipient success: an ideal study using a paired analysis of sibling-oocytes

Cited by 5 publications

References 30 publications

Live birth outcomes in infertile patients with class III and class IV obesity following fresh embryo transfer

Live birth outcomes in infertile patients with class III and class IV obesity following fresh embryo transfer

Update on obesity and assisted reproductive technology

Obesity and Miscarriage

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