Body mass index is a good predictor of an elevated alanine transaminase level in the general population: hints from the Dionysos study

Bedogni, Giorgio; Miglioli, L.; Battistini, N.; Masutti, Flora; Tiribelli, Claudio; Bellentani, Stefano

doi:10.1016/s1590-8658(03)00378-5

Cited by 12 publications

(19 citation statements)

References 17 publications

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“…1-8,14 -16 Obesity is a frequently reported factor associated with both liver enzymes and cardiovascular disease. 1,3,[5][6][7][8] However, in our analyses, body mass index was not an important risk factor for ICH, and the association between aminotransferase level and ICH was also observed in men with a low body mass index. Aminotransferase levels are also known to be influenced by alcohol intake, 1,4,6,7 and heavy drinking can increase the risk of ICH.…”

Section: Aminotransferase and Traditional Risk Factorsmentioning

confidence: 88%

“…Epidemiologic studies have reported positive associations between serum aminotransferase levels and various conventional cardiovascular risk factors. [1][2][3][4][5][6][7][8] Nevertheless, a direct association between serum aminotransferase levels and the risk of cardiovascular disease has not been fully studied. Some patient studies reported a positive association between hemorrhagic stroke and a history of liver dysfunction, which was defined by elevated liver enzymes.…”

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confidence: 99%

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Elevated Serum Aminotransferase Level as a Predictor of Intracerebral Hemorrhage

Kim

Kang

Nam

et al. 2005

Stroke

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Section: Aminotransferase and Traditional Risk Factorsmentioning

confidence: 88%

mentioning

confidence: 99%

Elevated Serum Aminotransferase Level as a Predictor of Intracerebral Hemorrhage

Kim

Kang

Nam

et al. 2005

Stroke

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“…This value corresponded to the 99th internal percentile. We chose a value of ALT >30 U L À1 to allow comparison with previous studies (Strauss et al 2000) and because values greater than 60 U L À1 (Sherwood et al 2001, Bedogni et al 2003 are uncommon in adolescents. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated and the goodness of fit of models including continuous predictors was evaluated using the Hosmer-Lemeshow statistic (Hosmer and Lemeshow 2000).…”

Section: Discussionmentioning

confidence: 99%

“…>60 U L À1 ). The accuracy of the prediction increased, however, from 0.65 to 0.75 when gender, ethanol consumption, and HBV and HCV infections were considered as predictors together with BMI (Bedogni et al 2003). Because alcohol consumption, and HBV and HCV infections are less common in adolescents, we hypothesized that BMI could be an even more important predictor of elevated ALT in adolescents.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of body mass index in detecting an elevated alanine aminotransferase level in adolescents

Bedogni

Miglioli

Masutti

et al. 2004

Annals of Human Biology

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Aim: We evaluated the accuracy of body mass index (BMI) in detecting an elevated alanine aminotransferase (ALT) level in adolescents, taking into account the effects of gender, age, ethanol intake, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, and drug consumption. Subjects: A representative sample of 454 adolescents (11-17 years) from two cities in northern Italy was studied (the Dionysos Study). Methods: z-BMI was calculated as the z-score of BMI using national growth charts. Logistic regression was used to quantify the contribution of the variables of interest to an elevated ALT (>30 UL À1 ). Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated, and areas under receiver-operator characteristic curves (AUC) were used to evaluate accuracy. Results: An elevated ALT was detected in 21 adolescents (4.6%). Among the studied variables, only male gender (OR ¼ 6.7, 95% CI 2.0-23.2) and z-BMI (OR ¼ 2.1, 95% CI 1.4-3.2) were significant predictors of elevated ALT. The accuracy of the prediction was 0.69 (95% CI 0.59-0.79) for gender and 0.71 (95% CI 0.59-0.81) for z-BMI. By combining gender and z-BMI, the accuracy rose to 0.80 (95% CI 0.71-0.89). Conclusion: BMI is a good predictor of elevated ALT in Italian adolescents and gender adds to the accuracy of the prediction.

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“…In recent researches reported that, in 3D environments, E-cadherin deficiency indeed led to a loss of intercellular adhesion and triggered tumor cell invasion by matrix MMP-2 and MMP-9 driven matrix degradation. Surface tension at the tumor-tissue interface, have been extensively studied in the field of fluid dynamics (44,45,46,47). Promoting tumor cell adhesion and thus increasing the tumor surface tension can induce cellular cohesiveness and decreasing of the invasiveness.…”

Section: Physical Factors and Reciprocitymentioning

confidence: 99%

Invasion Mechanisms of Bladder Cancer: A Molecular Review

Narter¹,

Sabuncu²

2016

jus

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ÖZBladder cancer (BC) is a very common cancer and it has high mortality rates, especially in late stages. BC is considered as a different disease in various stages and grades. Non-muscle-invasive BC and muscle-invasive BC have different properties. There are some prognostic factors for progression and recurrence rates of BC and we have some risk assessment methods. These factors are based on clinical findings and histopathological properties. We do not know which factors and molecular processes are effective in the invasion mechanism. In this review, we summarized possible invasion mechanisms of BC. KeywordsBladder cancer, invasion, metastasis, molecularMesane kanseri farklı evrelerde farklı birer hastalık gibi kabul ve tedavi edilir. Her evre tekrarlama ve ilerleme açısından farklı riskler taşır. Günümüzde bu tekrarlama ve ilerleme risklerini gösteren değişik hesaplama sistemleri tanımlansa da altta yatan moleküler, genetik ve çevresel faktörler net olarak gösterilememiştir. Mevcut risk hesaplama sistemleri klinik, makroskopik ve patolojik değerlendirme temellerine oturmaktadır. Derlemede özetlemeye çalıştığımız olası invazyon mekanizmaları aydınlatıldıkça prognostik yeni moleküler faktörlerin tanımlanması, hatta bu temelde yeni tedavi metodlarının geliştirilmesi mümkün olacaktır. Anahtar KelimelerMesane kanseri, invazyon, metastaz, moleküler IntroductionUrothelial tumors are classified as papillary and nonpapillary (solid) tumors. Histopathologically, more than 90% of bladder cancers (BCs) are urothelial (transitional) cell carcinomas (UCC or TCC). At the time of diagnosis, about 75% of BCs are non-muscle-invasive bladder cancer (NMIBC) and remaining 25% are muscle-invasive bladder cancer (MIBC). Phenotypes and genotypes of these cancers in various stages are different. In this context, 30% to 50% of NMIBCs recur after transurethral resection of the primary tumor, and 10% to 20% progress to MIBC. Many of high-grade carcinomas (including carcinoma in situ) invade the bladder wall and may metastasize to other sites. Additionally, nearly 50% of patients with MIBCs have occult distant metastases at the time of diagnosis (1,2). Recently, in the literature, there are many studies in which molecular, genetic and physical factors have been investigated in the progression and recurrence of the BC but it has not been fully outlined. All these factors affect the process of metastasis, invasion and resistance to therapy. Generally, major characteristics of malignant cancer cells are defined as self-sufficiency in growth signals, insensitivity to anti-growth signals, tissue invasion and metastasis, limitless replicative potential, sustained angiogenesis, and evading apoptosis. Additionally, tumor metastasis includes detachment, migration, invasion, intravasation, anoikis, evasion, and extravasation steps. In this review, we aimed to summarize the possible genetic, molecular and physical factors that are responsible for the progression and recurrence. Epithelial-Mesenchymal Transition and PlasticityMechanism of the...

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Body mass index is a good predictor of an elevated alanine transaminase level in the general population: hints from the Dionysos study

Cited by 12 publications

References 17 publications

Elevated Serum Aminotransferase Level as a Predictor of Intracerebral Hemorrhage

Elevated Serum Aminotransferase Level as a Predictor of Intracerebral Hemorrhage

Accuracy of body mass index in detecting an elevated alanine aminotransferase level in adolescents

Invasion Mechanisms of Bladder Cancer: A Molecular Review

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