Body Mass Index in Mild Cognitive Impairment According to Age, Sex, Cognitive Intervention, and Hypertension and Risk of Progression to Alzheimer's Disease

Joo, Soo Hyun; Yun, Se Hee; Kang, Dong Woo; Hahn, Changtae; Lim, Hyun Kook; Lee, Chang Uk

doi:10.3389/fpsyt.2018.00142

Cited by 46 publications

(36 citation statements)

References 37 publications

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“…Another study showed that participants with a baseline BMI ≥ 25 kg/m 2 had significantly higher MMSE scores compared with participants with BMI < 25 kg/m 2 (Coin et al, 2012). In mild cognitive impair- (Joo et al, 2018). Moreover, Qizilbash N1 conducted a study in the UK and showed that underweight people had a higher risk of dementia, and the incidence of dementia continued to decrease when BMI increased (Qizilbash et al, 2015), which is consistent with our study.…”

Section: Ta B L E 3 Relevance Between 3-month Mmse Scores and Baselinsupporting

confidence: 89%

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High levels of plasma fibrinogen are related to post‐stroke cognitive impairment

et al. 2019

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Introduction Studies have shown that high levels of the fibrinogen (FIB) are related to cognitive deficits. However, the relationship between fibrinogen and cognitive deficit after stroke remains unclear. Therefore, we explored the relationship between plasma fibrinogen and post‐stroke cognitive impairment (PSCI). Methods This study is carried out in the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China. A total of 210 patients with acute ischemic stroke were enrolled in this study. Ultimately, 134 patients completed 3‐month follow‐up. Blood samples were collected at hospital admission. Cognitive function was evaluated 3 months after stroke. All patients underwent the Mini‐Mental State Examination (MMSE) after 3 months. Results Higher levels of fibrinogen were observed in patients with post‐stroke cognitive impairment compared with the non‐PSCI group (p < .001). Additionally, elevated plasma fibrinogen levels were independently associated with PSCI (odds ratio [OR] = 2.000, 95% CI 1.062–3.770 p = .032). The plasma fibrinogen levels were negatively correlated with the 3‐month MMSE scores (r = −.171, p = .048). In a multivariate linear regression, FIB was negatively associated with the 3‐month MMSE scores after adjustment for the other variables (β = −0.782, p = .035). Conclusion High levels of plasma fibrinogen were associated with the presence and severity of PSCI.

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Section: Ta B L E 3 Relevance Between 3-month Mmse Scores and Baselinsupporting

confidence: 89%

“…It has been shown that long-term intake of high-fat diets, even in the absence of obesity, leads to cognitive deficits (Cifre, Palou, & Oliver, 2018). (Joo et al, 2018). (Joo et al, 2018).…”

Section: Tions Can Inhibit Both Aβ Deposition and Tau Hyperphosphorylmentioning

confidence: 99%

High levels of plasma fibrinogen are related to post‐stroke cognitive impairment

et al. 2019

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“…The underlying mechanism linking BMI and cognition is not fully understood and requires further research, however some studies have shown that higher BMI in elderly patients is associated with a lower risk of cognitive impairment and dementia [ 51 ], as well as longer survival [ 32 ]. In the latest prospective study, low baseline BMI might be a useful marker for identifying individuals at increased risk for Alzheimer’s Disease in the Mild Cognitive Impairment subjects [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Functioning of Geriatric Patients: Is Hypovitaminosis D the Next Marker of Cognitive Dysfunction and Dementia?

2018

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The study objective is to investigate whether vitamin D is associated with the cognitive function of geriatric patients. This cross-sectional study involved 357 patients hospitalized in the geriatric ward who complained of memory problems (mean age: 82.3 years). The level of cognitive function was measured with the Mini-Mental State Examination (MMSE) and the clinical diagnosis of dementia was established according to the International Classification of Diseases (ICD-10) criteria. The serum 25-hydroxy vitamin D was measured with liquid chromatography-tandem mass spectrometry. The iterative Bayesian model averaging (BMA) procedure was applied to linear and logistic regression models in order to identify the best set of factors describing cognitive dysfunction and dementia, respectively. According to BMA, there is strong evidence that higher vitamin D levels, higher body mass index (BMI), and higher mobility function measured with the Timed Up and Go (TUG) test are independently associated with better cognitive performance and lower risk of dementia. Additionally, there is strong evidence that fewer years of education and lower vitamin B12 plasma levels independently describe worse cognitive performance. However, vitamin B12 levels higher than 800 pg/mL is negatively associated with the MMSE performance. Hypovitaminosis D in geriatric patients is an underrated marker of cognitive dysfunction and dementia.

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“…However, in a population of more than three hundred thousand olderly individuals, Qizilbash and colleagues found a lower risk of dementia in people who are overweight and obese, after adjustment for nine potential confounders: age, sex, smoking, alcohol, history of myocardial infraction, stroke and diabetes, use of recent anti-hypertensive drugs, and statins [35]. In other studies adjusted for several important potential confounders, researchers also reported that obesity at baseline predicted a lower risk of AD in elderly people [20,36,37]. Additionally, the results from our study confirmed a higher late-life BMI was associated with lower AD-related biological biomarkers in prodromal AD, larger brain volumes of AD-vulnerable regions and better cognitive performance.…”

Section: Agingmentioning

confidence: 99%

Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study

Sun

Wang

Sun

et al. 2020

Aging

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Higher body mass index (BMI) in late-life has recently been considered as a possible protective factor for Alzheimer's disease (AD), which yet remains conflicting. To test this hypothesis, we have evaluated the crosssectional and longitudinal associations of BMI categories with CSF biomarkers, brain β-amyloid (Aβ) load, brain structure, and cognition and have assessed the effect of late-life BMI on AD risk in a large sample (n = 1,212) of nondemented elderly from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. At baseline, higher latelife BMI categories were associated with higher levels of CSF Aβ42 (p=0.037), lower levels of CSF total-tau (t-tau, p=0.026) and CSF t-tau/Aβ42 (p=0.008), lower load of Aβ in the right hippocampus (p=0.030), as well as larger volumes of hippocampus (p<0.0001), entorhinal cortex (p=0.009) and middle temporal lobe (p=0.040). But no association was found with CSF phosphorylated-tau (p-tau) or CSF p-tau/Aβ42. Longitudinal studies showed that higher BMI individuals experienced a slower decline in cognitive function. In addition, Kaplan-Meier survival analysis revealed that higher late-life BMI had a reduced risk of progression to AD over time (p = 0.009). Higher BMI in late-life decreased the risk of AD, and this process may be driven by AD-related biomarkers.

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Body Mass Index in Mild Cognitive Impairment According to Age, Sex, Cognitive Intervention, and Hypertension and Risk of Progression to Alzheimer's Disease

Cited by 46 publications

References 37 publications

High levels of plasma fibrinogen are related to post‐stroke cognitive impairment

High levels of plasma fibrinogen are related to post‐stroke cognitive impairment

Cognitive Functioning of Geriatric Patients: Is Hypovitaminosis D the Next Marker of Cognitive Dysfunction and Dementia?

Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study

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