Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort

Hazzouri, Adina Zeki Al; Vittinghoff, Eric; Hoang, Tina; Golden, Sherita Hill; Fitzpatrick, Annette L.; Zhang, Adina; Grasset, Leslie; Yaffe, Kristine

doi:10.1002/alz.12367

Cited by 20 publications

(13 citation statements)

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“…The association between midlife BMI with cognition and risk of dementia is well established, 1 and evidence is emerging that higher BMI during early adulthood can increase the risk for dementia 18 . Several mechanisms may underlie the BMI–cognition link.…”

Section: Discussionmentioning

confidence: 99%

Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk

West

Ravona‐Springer

Sharvit‐Ginon

et al. 2021

Alz & Dem Diag Ass & Dis Mo

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Introduction We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long‐term trajectories of BMI with cognition. Results Higher BMI was associated with worse language (P = .045). Interactions of BMI with parental history were significant for episodic memory (P = .023), language (p = .027), working memory (P = .006), global cognition (P = .008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P = .017), language (P = .013), working memory (P = .001), global cognition (P = .005), with stronger associations for maternal history. Discussion Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.

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Section: Discussionmentioning

confidence: 99%

Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk

West

Ravona‐Springer

Sharvit‐Ginon

et al. 2021

Alz & Dem Diag Ass & Dis Mo

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“…[31] Therefore, a BMI outside the normal range is correlated with dementia and cognitive impairment in older men and women. [32–34]…”

Section: Resultsmentioning

confidence: 99%

“…[31] Therefore, a BMI outside the normal range is correlated with dementia and cognitive impairment in older men and women. [32][33][34] 3.1.4. Eat a balanced, rainbow, mediterranean, DASH, and/or mind diet.…”

Section: Physical Health Promotion With Dementia Preventionmentioning

confidence: 99%

Concepts of dementia prevention in the health promotion among older adults: A narrative review

Tsai

Shen

2022

Medicine

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The number of older adults with dementia is predicted to markedly increase in the coming decades. A person suffers from dementia every 3 seconds globally, and one out of every 7 people suffers from dementia in Taiwan. The purpose of this narrative review is to integrate existing concepts of dementia prevention into health promotion and improve older adults’ quality of life. This narrative review was performed using the PubMed database by searching for basic research and systematic reviews on dementia prevention and health promotion among older adults. We established a framework for dementia prevention and health promotion with regard to the physical, mental, spiritual, and social health aspects. We identified the following strategies related to older adults towards dementia prevention and health promotion in follows: Physical health promotion: cognitive activities, physical activities, body mass index, balanced diet, rainbow diet, Mediterranean diet, dietary approaches to stop hypertension diet, mind diet, no smoking and drinking, avoiding the “three highs” (i.e., hyperglycemia, hyperlipidemia, and hypertension), and head trauma; Mental health promotion: Positive thinking, Brief Symptom Rating Scale (BSRS-5), depression scale, and ascertained dementia 8 questionnaire (AD8) screening; Spiritual health promotion: religious beliefs, spiritual music, meditative activities, mindfulness, yoga, Qi-gong, Tai-chi, and Baduanjin; and Social health promotion: A supportive family system, socialization, social support, social networks, social interaction, and social participation. The conclusion of this narrative review was to integrate the concepts of dementia prevention and health promotion among older adults.

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“…A small number of initiatives have pooled studies from across the life course to create synthetic cohorts. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Within this literature, limited attention has been paid to the causal conditions under which unbiased effect estimation from synthetic cohorts is achievable. 21 Recent work on the "data fusion" problem provides a formal causal inference framework for pooling heterogeneous data sets, [22][23][24][25] focused on transporting models from one population to another.…”

Section: Introductionmentioning

confidence: 99%

Overcoming data gaps in life course epidemiology by matching across cohorts

Kezios

Zimmerman

Rudolph

et al. 2020

Preprint

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Research on Alzheimer's Disease and Related Dementias (ADRD) is hampered by the absence of studies including prospective follow-up from early life through older ages when ADRD is diagnosed. This is a notable gap in the United States and impedes research on lifecourse determinants of ADRD and ADRD disparities, many of which appear attributable to early life experiences. In this simulation project, we evaluate a matching method to create a synthetic lifecourse cohort by merging early and late life cohorts on a set of harmonized covariates. We evaluate performance under several causal scenarios for the association between our exposure and outcome, and varying characteristics of the matching method. In scenarios when a measure is available along all pathways linking exposure and outcome, the synthetic cohort performs well, with bias approaching null as the number of matching levels increases. This approach may create novel opportunities to rigorously evaluate early- and mid-life determinants of ADRD and ADRD disparities.

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Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort

Cited by 20 publications

References 58 publications

Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk

Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk

Concepts of dementia prevention in the health promotion among older adults: A narrative review

Overcoming data gaps in life course epidemiology by matching across cohorts

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