Body Mass Index (BMI) Is Associated with Microalbuminuria in Chinese Hypertensive Patients

Abstract

There is no general consensus on possible factors associated with microalbuminuria in hypertensive patients nor any reported study about this issue in Chinese patients. To examine this issues, 944 hypertensive patients were enrolled in a study based on a cross-sectional survey conducted in Southern China. Multivariate regression analyses were performed to identify the factors related with the presence of microalbuminuria and urinary excretion of albumin. The prevalence of microalbuminuria in hypertensive and non-diabetic hypertensive patients were 17.16% and 15.25%, respectively. Body mass index (BMI), but not waist circumference (WC), were independently associated with microalbuminuria and the values of urinary albumin to creatinine ratio (ACR) based on multiple regression analyses, even after excluding diabetic patients and patients taking inhibitors of the renin-angiotensin system from the analyses. Furthermore, patients with obesity (BMI ≥28) had higher levels of ACR, compared with those with normal weight (BMI <24 kg/m2) and overweight (24 kg/m2≤ BMI < 28). In conclusion, BMI, as a modifiable factor, is closely associated with microalbuminuria among Chinese hypertensive patients, which may provide a basis for future development of intervention approaches for these patients.

Association between the Degree of Obesity and the Development of Microalbuminuria in Korean Men: Prospective Cohort Study

“…Thus, this finding implies that obese people have the higher likelihood for the development of microalbuminuira than others. Additionally, this finding is supported by previous studies reporting the positive relationship between the obesity and microalbuminuria [7][8][9]. Especially, recent body of evidence focused the significant relationship between microalbuminuria and central or visceral obesity.…”

“…Microalbuminuria, defined as a urinary albumin-to-creatinine (UACR) ranging within 30-300 mg/g, is usually used in evaluating and managing diabetic nephropathy [5,6]. Body of evidence indicated that obesity was deeply associated with diabetic nephropathy manifested by microalbuminuria [7][8][9]. Additionally, even in non-diabetic patients, risk for microalbuminuria was related with the degree of obesity [10,11].…”

High dose versus low dose Aspirin after Percutaneous Coronary Intervention in Coronary Artery Disease

“…ST segment elevation MI cases were not included in their study 14 . Association of microalbuminuria with dyslipidemia and obesity was not significant in our study; however few studies have shown significant association 6,[15][16][17][18] . 98 out of 100 ACS patients in our study were having one or more risk factors.…”

Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension

“…Albuminuria can easily be assessed as albumin‐creatinine ratio (ACR) in urine samples even in simple clinical settings. Risk markers associated with presence of albuminuria in Caucasians and Asians with hypertension include age, diabetes mellitus (DM), obesity, smoking, and insufficient blood pressure (BP) control . Knowledge on risk markers suggesting presence of albuminuria among patients with hypertension in sub‐Saharan Africa (SSA) has only been investigated in urban areas and is, in general, comparable with those of the Western world .…”

“…Risk markers associated with presence of albuminuria in Caucasians and Asians with hypertension include age, diabetes mellitus (DM), obesity, smoking, and insufficient blood pressure (BP) control. 3,4 Knowledge on risk markers suggesting presence of albuminuria among patients with hypertension in sub-Saharan Africa (SSA) has only been investigated in urban areas and is, in general, comparable with those of the Western world. 5,6 The lifestyle and living conditions in rural areas of SSA differ from urban environments in terms of physical activity, nutrition, and patterns of cardiovascular disease.…”