Body Mass Index And Survival Rate in Nasopharyngeal Cancer Patient: An Evidence-based Case Report

Wulandari, Yohannessa; Satyani, Metta; Marino, M.; Manikam, Nurul Ratna Mutu

doi:10.25220/wnj.v03.i2.0005

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“…Several studies were conducted to determine the relationship between nutritional status through Body Mass Index (BMI) and NPC patients' survival rate, but the results were still inconsistent. Wulandari et al 11 suggest that patients with a higher BMI have a better survival rate, and increasing BMI in underweight NPC patients can improve the survival of NPC. Karnofsky performance status (KPS) is a value of functional status of patients measured from a value of 0-100 percent.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Neck Nodule Size with Body Mass Index and Karnofsky Status Before and After Neoadjuvant Cisplatin and 5-Fluorouracil Chemotherapy in Nasopharyngeal Carcinoma Type 3 Patients

Efranto

Soehartono

Handoko

2021

Oto Rhino Laryn Indones

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Introduction: Nasopharyngeal carcinoma (NPC) is a malignancy arising from the nasopharyngeal epithelium, usually present in the Rosenmüller fossa. NPC is a cancer of the head and neck that is most common in East Asia and Southeast Asia, including in Indonesia. The main therapeutic for NPC is radiotherapy. Neoadjuvant chemotherapy reduces the local spread of advanced NPC, eradication of micrometastases, and improved local control. Neoadjuvant chemotherapy's effectiveness can be assessed by changes in the patient's neck nodule size (N), the patient's Body Mass Index (BMI), and Karnofsky's Status. Aim: To determine the correlation between N with BMI and Karnofsky status on neoadjuvant chemotherapy Cisplatin and 5-Fu in WHO type 3 of NPC patients. Methods: This study was an analytical observational study using medical record data. In this study, an assessment of N, BMI and Karnofsky status of NPC WHO type 3 patients who had undergone neoadjuvant chemotherapy using the Cisplatin and 5-Fu regimen for three cycles. Twenty-three study subjects were analyzed for N, BMI and Karnofksy status changes while undergoing neoadjuvant chemotherapy for up to 3 cycles. Result: The N value decreased, p = 0.001. BMI value decreased, p = 0.615. Karnofsky's status value experienced insignificant changes, p = 0.564. The correlation between N and BMI before a cycle I neoadjuvant chemotherapy and three cycles of neoadjuvant chemotherapy obtained r = -0.201 and p = 0.358, respectively; r = -0.070 and p = 0.751. Correlation of N with Karnofsky status was obtained r = 0.155 and p = 0.480, before cycle I neoadjuvant chemotherapy. The correlation between N and Karnofsky status was obtained r = 0.571 and p = 0.004 after cycle III neoadjuvant chemotherapy. Conclusion: Neoadjuvant chemotherapy Cisplatin and 5-Fu is effective against changes in N and correlation between N and BMI but less effective in assessing the correlation between N and Karnofsky status after three cycles of neoadjuvant chemotherapy. Correspondence should be addressed to Bagus Harning Efranto; bagushe16@gmail.com

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Section: Introductionmentioning

confidence: 99%