Body Mass Index and Serum 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)Ethane in Nulliparous Chinese Women

Abstract

Background: Basic health indicators, such as body mass index (BMI), have been associated with serum 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane/1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDT/DDE) levels; however, both positive and inverse associations of BMI with serum DDT/DDE have been reported. Given the association of BMI with a number of outcomes, it may confound studies of DDT/DDE-associated health effects. We investigated the relationship of BMI with serum DDT/DDE accounting for other determinants of exposure among women with relatively recent environmental exposures to DDT. Methods: Serum DDT/DDE was analyzed in 466 nonsmoking, nulliparous women recruited from Anhui province in China between 1996 and 1998 as part of a reproductive health study of textile workers. The women in the sample were born between 1963 and 1977, 8 to 21 years before China's 1984

Pharmacokinetic Variability and Modern Epidemiology—The Example of Dichlorodiphenyltrichloroethane, Body Mass Index, and Birth Cohort

“…When this model is adapted to depict DDT levels in sequential birth cohorts (Fig. 3), the observed DDT-BMI relationships in successive cohorts behave just like those reported by Perry et al (9). That is, later birth cohorts (i.e., younger individuals) have smaller negative slopes (DDDT/DBMI) in their first 10 to 20 years of exposure.…”

“…8). The 1999 letter was also generously cited in another Cancer Epidemiology Biomarkers & Prevention article (9), the report that prompts the current comment.…”

“…A new wrinkle arose in this argument with the noteworthy report from Perry et al (9), which found that the magnitude of the negative slope for DDT versus BMI varied by year of birth independent of age. First, the strong negative association between DDT residues and BMI indicates that exposure was recent and/or ongoing.…”

“…3A, for the first year of DDT exposure for the 1962, 1965, and 1967 cohorts, the model-estimated slopes for blood are À1.8, À1.5, À0.8, respectively (using 0.7% serum lipid to extrapolate to serum wet basis, which is the unit reported in ref. 9).…”

Factors predicting organochlorine pesticide levels in pregnant Latina women living in a United States agricultural area

“…Body burden of OC pesticides has been negatively associated with breastfeeding (Lopez-Carrillo et al, 2001;Moysich et al, 2002) and positively associated with age (Torres-Arreola et al, 1999), dietary intake of lipid-rich foods such as meat, fish and dairy (Torres-Arreola et al, 1999;Moysich et al, 2002;Sarcinelli et al, 2003), origin from a geographic area with recent or more intense use of OC pesticides (Waliszewski et al, 2000;Wolff et al, 2005) and smoking (Lackmann et al, 2000;Deutch et al, 2003). Serum levels of OC pesticides have been both positively (Glynn et al, 2003) and negatively (Perry et al, 2005) associated with body mass index (BMI) and recent weight change (Glynn et al, 2003).…”