Body mass index and serum folate in childbearing age women

Mojtabai, Ramin

doi:10.1007/s10654-004-2253-z

Cited by 198 publications

(131 citation statements)

References 31 publications

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“…Therefore, it is hardly surprising that the prevalence of neonatal neural tube defects is raised in obesity, given the likelihood of folate deficiency. 87,88 Management of obesity in pregnancy and between pregnancies…”

Section: Lipid Turnovermentioning

confidence: 99%

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

Dennedy

Dunne

2010

Best Practice & Research Clinical Endocrinology & Metab

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Section: Lipid Turnovermentioning

confidence: 99%

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

Dennedy

Dunne

2010

Best Practice & Research Clinical Endocrinology & Metab

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“…However, research on the relationship between obesity and folate levels is only now evolving and includes only a handful of studies to date. Mojtabai (2004) found that increased body mass index (BMI) in US women of childbearing age was associated with lower serum folate levels both before and after folic acid fortification. Tungtrongchitr et al (2003), reported that obese Thai subjects have lower serum folate than normal weight subjects.…”

Section: Introductionmentioning

confidence: 99%

Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study

et al. 2007

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Objective: To assess the associations between serum folate concentration and measures of adiposity in postmenopausal women. Design: This study was conducted as a cross-sectional analysis within the control segment of a randomized, crossover trial in which postmenopausal women (n ¼ 51) consumed 0 g (control), 15 g (one drink) and 30 g (two drinks) alcohol (ethanol)/day for 8 weeks as part of a controlled diet. Subjects in one treatment arm were crossed-over to another arm after a 2-to 5-week washout period. Body mass index (BMI) was measured, and dual energy X-ray absorptiometry (DEXA) scan administered to the women during the control (0 g alcohol) treatment, and a blood sample from this group was collected at baseline and week 8 of each diet period and analyzed for folate, B12, homocysteine and methylmalonic acid. Setting: This study was conducted at the Beltsville Human Nutrition Research Center, MD, USA. Results: In multivariate analysis, women who were overweight had a 12% lower, and obese women had a 22% lower serum folate concentrations compared to normal weight women (P-trend ¼ 0.02). Vitamin B12 also decreased with increasing BMI (P-trend ¼ 0.08). Increased BMI, percent body fat, and absolute amounts of central and peripheral fat were all significantly associated with decreased serum folate, but were unrelated to serum B12, homocysteine or methylmalonic acid. Conclusions: Our data show that adiposity is associated with lower serum folate levels in postmenopausal women. With obesity at epidemic proportions, these data, if confirmed by prospective or randomized controlled studies, have important public health implications.

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“…Previous studies have observed a differential association between obesity and serum and red-blood-cell (RBC) folate concentrations in men, non-pregnant women of childbearing age and postmenopausal women (1)(2)(3)(4)(5) . Specifically, serum folate was found to be negatively associated, while RBC folate was positively associated, with BMI among non-pregnant adults (1)(2)(3)(4)(5) . The mechanisms for this differential association of obesity with serum and RBC folate concentrations are not clearly understood.…”

mentioning

confidence: 99%

Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women

Shen

Chaudhry

MacFarlane

et al. 2016

Public Health Nutr.

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Objective: To examine the association between BMI and folate concentrations in serum and red blood cells (RBC) in pregnant women. Design: A cross-sectional comparison of folate concentrations in serum and RBC sampled simultaneously from the same individual. Setting: The Ottawa Hospital and Kingston General Hospital, Ontario, Canada. Subjects: Pregnant women recruited between 12 and 20 weeks of gestation. Results: A total of 869 pregnant women recruited from April 2008 to April 2009 were included in the final analysis. Serum folate was inversely associated and RBC folate positively associated with BMI, after adjusting for folic acid supplementation, age, gestational age at blood sample collection, race, maternal education, annual income, smoking and MTHFR 677C→T genotype. In stratified analyses, this differential association was significant in women with the MTHFR CC variant. In women with the CT and TT variants, the differential associations were in the same direction but not significant. Folic acid supplementation during pregnancy did not alter the differential association of BMI with serum and RBC folate concentration. This indicates that the current RBC folate cut-off approach for assessing risk of neural tube defects in obese women may be limited. Conclusions: BMI is inversely associated with serum folate and positively associated with RBC folate in pregnant women, especially for those with the MTHFR CC variant.

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Body mass index and serum folate in childbearing age women

Abstract: Lower folate level may be one mechanism linking higher maternal BMI and increased risk of NTDs in the offspring. If corroborated in future studies, findings from this study suggest a need for a higher dose of folate supplement in heavier childbearing age women.

Cited by 198 publications

References 31 publications

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study

Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women

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