Body Mass Index and Risk for End-Stage Renal Disease

Hsu, Chi-yuan; McCulloch, Charles E.; Iribarren, Carlos; Darbinian, Jeanne; Go, Alan S.

doi:10.7326/0003-4819-144-1-200601030-00006

Cited by 1,169 publications

(759 citation statements)

References 40 publications

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“…Accumulating evidence indicates that higher BMI is a risk factor for CKD in apparently healthy persons [28, 29], and graft loss in kidney transplantation recipients [30]. The result of a recent study from Taiwan [31] also supports this notion.…”

Section: Discussionsupporting

confidence: 74%

Outcomes of Stage 3–5 Chronic Kidney Disease before End-Stage Renal Disease at a Single Center in Taiwan

et al. 2008

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Background: Taiwan has the highest incidence of end-stage renal disease (ESRD) in the world, but little is known about the outcomes of patients with chronic kidney disease (CKD) before ESRD in Taiwan. This study investigated the rate of renal progression and predictors for ESRD and death in a prospective cohort of patients under usual nephrologic care at a single center. Methods: A total of 433 patients at CKD stage 3–5 short of dialysis were recruited from nephrology clinics. Patients were monitored for up to 36 months or until ESRD, death or loss to follow-up. Glomerular filtration rates (GFR) were calculated by the Modification of Diet in Renal Disease abbreviated formula. Results: At baseline, mean age was 65.6 years, 61.7% were male, 33.3% were diabetic and 29.1% had cardiovascular diseases (CVD). At the end of follow-up, 123 patients (28.4%) had advanced to ESRD and 41 (9.5%) had died. Mean annual declines in GFR were 2.24, 4.22, and 3.23 ml/min/1.73 m² for stages 3, 4, and 5, respectively. By Cox regression model, patients with CVD, lower BMI and higher systolic BP were more likely to develop ESRD. Older patients with CVD and lower systolic BP were more likely to die. Conclusion: In this CKD cohort, patients were more likely to develop ESRD than cardiovascular death. The rate of GFR decline and predictors of ESRD were comparable to those reported in Western countries. Thus, the high incidence of ESRD in Taiwan may be attributed, at least in part, to lower cardiovascular mortality.

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Section: Discussionsupporting

confidence: 74%

Outcomes of Stage 3–5 Chronic Kidney Disease before End-Stage Renal Disease at a Single Center in Taiwan

et al. 2008

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“…No relation was found between renal size and body habitus and it was concluded that renal size was independent of BMI, which concurred with the studies carried out in the past [1,45]. Several researches reported that increased BMI was closely associated with the increased risk of developing chronic renal disease as well as ESRD (end stage renal disease) [48][49][50].…”

Section: Bmi Influencing the Renal Volumesupporting

confidence: 62%

Relation between Renal Length and Renal Volume with Patient’s BMI: A Critical Appraisal

Paul¹,

Talhar²,

Sontakke³

et al. 2016

Anat Physiol

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In urological and nephrological practices, evaluation of kidney size imparts a valuable diagnostic parameter. Age, gender, body mass index, pregnancy and co-morbid conditions such as diabetes mellitus, hypertension are supposed to affect the renal size. Measurements of renal dimensions can be carried out by using different modern techniques like ultrasonography, CT scan and MRI. On the other hand body mass index (BMI) provides information to know the patient's obesity which is based on patient's height and weight. Information available from one particular region may not satisfy the other region as renal parameters varies with different ethnic group and body size. In this prospective, reviewing literature of different studies evaluated so far to predict the relationship between renal dimensions and BMI is carried out. These studies revealed that most of renal parameters were positively correlated with body size of an individual, therefore they can be used to estimate the size and volume of kidney. Moreover, the standard normal reference ranges for renal volume and size can serve as gold standard and acts as an adjunct to judge the atrophic or hypertrophic condition of kidney. Hence, establishing relationship between measured renal dimensions and BMI will serve as a useful guideline for detection of diseased condition of kidney. This paper sets out to present published data on researches that has fortified knowledge and understanding of correlation between different renal parameters and BMI, keeping in mind different demographic background. Thus here we are putting a comprehensive account of the studies carried out globally to establish the inter-relationship between renal dimensions with BMI which definitely helps the nephrologists in early diagnosing the renal diseases.

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“…Furthermore, in numerous large population-based studies, higher BMI appears associated with the presence 8,12 and development of low estimated glomerular filtration rate (GFR), 9,10,13 with more rapid loss of estimated GFR over time, 14 and with the incidence of ESRD. [15][16][17][18] Elevated BMI levels, class II obesity and above, have been associated with more rapid progression of CKD in patients with pre-existing CKD. 19 A few studies examining the association of abdominal obesity using WHR or WC with CKD, describe an association between higher girth and albuminuria, 20 Higher visceral adipose tissue measured by computed tomography has been associated with a higher prevalence of albuminuria in men.…”

Section: Association Of Obesity With Ckd and Other Renal Complicationsmentioning

confidence: 99%

Obesity and Kidney Disease: Hidden Consequences of the Epidemic

Kövesdy¹,

Furth²,

Zoccali³

2017

Nephrol Open J

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Body Mass Index and Risk for End-Stage Renal Disease

Abstract: High BMI is a common, strong, and potentially modifiable risk factor for ESRD.

Cited by 1,169 publications

References 40 publications

Outcomes of Stage 3–5 Chronic Kidney Disease before End-Stage Renal Disease at a Single Center in Taiwan

Outcomes of Stage 3–5 Chronic Kidney Disease before End-Stage Renal Disease at a Single Center in Taiwan

Relation between Renal Length and Renal Volume with Patient’s BMI: A Critical Appraisal

Obesity and Kidney Disease: Hidden Consequences of the Epidemic

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