Body mass index and postoperative complications in kidney transplant recipients

Zrim, Stephanie; Furlong, Timothy J.; Grace, Blair; Meade, Anthony

doi:10.1111/j.1440-1797.2012.01621.x

Cited by 53 publications

(32 citation statements)

References 26 publications

(60 reference statements)

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“…Finally, 8 eligible studies were included in this meta-analysis. 6,7,[12][13][14][15][16][17] characteristics and quality of the enrolled studies Table 1 shows the basic information for the metaanalysis. The enrolled 8 studies were published between 2010 and 2014.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…The enrolled 8 studies were published between 2010 and 2014. Among the enrolled 8 studies, patients in 5 studies were from America, patients from 2 studies were located in Australia, 12,17 and 1 study was conducted in Brazil. 15 The followup period ranged from 1 to 10 years.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Delayed graft function was assessed in 7 studies, 6,7,[12][13][14][15]17 which included 957 patients with BMI ranging from 25 to 30 kg/m 2 and 1320 patients with BMI ranging from 18.5 to 25 kg/m 2 . As shown in Figure 2A, significant heterogeneity was observed among enrolled studies (I 2 = 75%, P < .001), and effect size was pooled using the random effects model.…”

Section: Meta-analysis Of Overweight and Posttransplant Outcomes: Delmentioning

confidence: 99%

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Li¹,

Jin²,

Li³

et al. 2017

Exp Clin Transplant

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Objectives: Our study aimed to evaluate the effects of being overweight on kidney transplant. Materials and Methods: Our study evaluated kidney transplant recipients with body mass index ranging from 25 to 30 kg/m 2 versus patients with body mass index ranging from 18.5 to 29.9 kg/m 2 , who were identified through PubMed, Embase, and Cochrane Library searches up to October 2015. Outcomes analyzed included delayed graft function, acute rejection, graft loss, and patient survival. Furthermore, sensitivity analysis and funnel plots were conducted to evaluate the strength of our meta-analysis. Results: Eight studies were included in the metaanalysis. No association between being overweight and kidney transplant outcomes, including delayed graft function (risk ratio of 0.99; 95% confidence interval, 0.73-1.35), acute rejection (risk ratio of 1.11;95% confidence interval, 0.88-1.40), graft loss (risk ratio of 1.10; 95% confidence interval, 0.86-1.39), and patient survival (risk ratio of 0.98; 95% confidence interval, 0.94-1.01) was found. Significant heterogeneity was calculated among studies investigating the relation between delayed graft function and being overweight. However, sensitivity analysis and funnel plots demonstrated that the results were stable. Conclusions:The meta-analysis results suggested that overweight patients and patients with normal weight have similar outcomes after kidney transplant. However, for Chinese individuals, the conclusion should be further verified by additional studies.

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Section: Statistical Analysesmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Meta-analysis Of Overweight and Posttransplant Outcomes: Delmentioning

confidence: 99%

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Untitled

Li¹,

Jin²,

Li³

et al. 2017

Exp Clin Transplant

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“…En el año 2014 el 39% de los adultos presentaban sobrepeso y el 13% obesidad (1). Esa tendencia también se puede observar en pacientes en listas de espera para trasplante renal.…”

Section: Introductionunclassified

Estudio del impacto del índice de masa corporal pretrasplante sobre el pronto funcionamiento del injerto renal

Castillo¹,

Fuente²,

Fuente³

et al. 2016

Nutr Hosp

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Fernández Castillo R, Cañadas de la Fuente GR, Cañadas de la Fuente GA, De la Fuente Solana EI, Esteban de la Rosa RJ,Bravo Soto J. Estudio del impacto del índice de masa corporal pretrasplante sobre el pronto funcionamiento del injerto renal. AbstractIntroduction: Obesity and overweight have adverse health effects contributing to the presence of oxidative metabolic and cardiovascular diseases that threaten the integrity of the graft. Objective: To investigate the infl uence of body mass index on pre transplant graft function one year after transplant by studying four different methods of measuring the glomerular fi ltration rate. Material and methods: The sample consisted of 1336 kidney transplant patients of both sexes, measurements were performed pre transplant and post transplant of biochemical parameters, anthropometric measurements and kidney function by glomerular fi ltration steps. Results: When an increased body mass index pretransplant occurs, there is a decrease in glomerular fi ltration rate measured by four different methods and greater percentage of rejections. Conclusions: A high body mass index pretransplant contributes to graft dysfunction, a decrease in glomerular fi ltration rate and graft complications in the fi rst year after transplant.

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“…Prognosticators include diabetes, a high body mass index (BMI), poor nutrition status, delayed graft function (DGF), longer operative times, advanced age, poor surgical technique, and nicotine consumption. 1,[5][6][7][8][9][10][11][12][13] The immunosuppressant regimen plays an integral role in the development of wound issues. Sirolimus, an mTOR inhibitor, has a well-known association with wound complications.…”

Section: Introductionmentioning

confidence: 99%

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Parsikia

Chang

et al. 2014

Exp Clin Transplant

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Objectives: This paper sought to determine if there were an association between drain placement and the incidence of wound complications. Materials and Methods: A single-center institutional review board-approved retrospective study between 2001 to 2008, comparing 680 kidney transplant patients who either had a drain placed or were left undrained. Linear regression modeling was used to adjust the risk factors between the groups. Patients received calcineurin inhibitors, steroids, and a mycophenolate formulation. The incidence of early major and minor wound complications were captured. Minor wound complications were defined as seroma, lymphocele, and perigraft fluid collection, and major wound complications were defined as wound dehiscence, hematomas, evisceration, infections, wound necrosis, and hernias. Patients with incomplete data or those taking sirolimus were excluded. Results: Six hundred eighty kidney transplant cases were reviewed. Four hundred seventy-nine received drains; 201 did not. Demographic analyses revealed that the drain group had a higher average value in age and body mass index. The drain group had a lower albumin and a lower mean platelet count after surgery. The number of patients without diabetes in the drain group numbered nearly twice as many as did those without drains. An attempt was made to statistically account for demographic differences.Seventy-eight of 479 drained patients (16.28%) and 24 of 201 no-drain patients (11.94%) had a wound complication. Minor wound complications were observed in 9 patients (1.88%) in the drain group and 6 in no-drain group (2.99%) (P = .3702). Major wound complications were observed in 58 patients in the drain group (12.18%) and 17 in the no-drain group (8.46%) (P = .1655). Drain placement had no effect on major or minor wound complications. Conclusions: Drain placement is not associated with major or minor wound complications in kidney transplants.

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Body mass index and postoperative complications in kidney transplant recipients

Cited by 53 publications

References 26 publications

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Estudio del impacto del índice de masa corporal pretrasplante sobre el pronto funcionamiento del injerto renal

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