Body mass index and physical activity and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies

Aune, Dagfinn; Sen, Abhijit; Leitzmann, Michael F.; Norat, Teresa; Tonstad, Serena; Vatten, Lars J.

doi:10.1007/s00394-017-1443-x

Cited by 72 publications

(65 citation statements)

References 39 publications

(71 reference statements)

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“…These findings have important clinical and public health implications because of the growing obesity epidemic worldwide, and add to the wide range of adverse health effects that already have been established to be related to excess weight . The current study suggests excess weight is a risk factor for urinary incontinence and underscores the importance of population‐wide policies and initiatives for prevention of overweight and obesity.…”

Section: Resultsmentioning

confidence: 54%

Body mass index, abdominal fatness, weight gain and the risk of urinary incontinence: a systematic review and dose–response meta‐analysis of prospective studies

Aune

Mahamat‐Saleh

Norat

et al. 2019

BJOG

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Background Adiposity has been associated with elevated risk of urinary incontinence in epidemiological studies; however, the strength of the association has differed between studies.Objectives To conduct a systematic literature review and doseresponse meta-analysis of prospective studies on adiposity and risk of urinary incontinence.Search strategy We searched PubMed and Embase databases up to 19 July 2017.Selection criteria Prospective cohort studies were included.Data collection and analysis Data were extracted by one reviewer and checked for accuracy by a second reviewer. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random effects models.Main results Twenty-four prospective studies were included. The summary RR per 5 kg/m 2 increment in body mass index (BMI) was 1.20 (95% CI 1.16-1.25, I 2 = 62%, n = 11) for populationbased studies and 1.19 (95% CI 1.08-1.30, I 2 = 87.1%, n = 8) for pregnancy-based studies, 1.18 (95% CI 1.14-1.22, I 2 = 0%, n = 2) per 10 cm increase in waist circumference and 1.34 (95% CI 1.11-1.62, I 2 = 90%, n = 2) per 10 kg of weight gain. Although the test for nonlinearity was significant for BMI, P = 0.04, the association was approximately linear. For subtypes of urinary incontinence the summary RR per 5 BMI units was 1.45 (95% CI 1.25-1.68, I 2 = 85%, n = 3) for frequent incontinence, 1.52 (95% CI 1.37-1.68, I 2 = 34%, n = 4) for severe incontinence, 1.33 (95% CI 1.26-1.41, I 2 = 0%, n = 8) for stress incontinence, 1.26 (95% CI 1.14-1.40, I 2 = 70%, n = 7) for urge incontinence, and 1.52 (95% CI 1.36-1.69, I 2 = 0%, n = 3) for mixed incontinence.Conclusion These results suggest excess weight may increase risk of urinary incontinence.Keywords Body mass index, meta-analysis, obesity, overweight, prospective studies, urinary incontinence, waist circumference.Tweetable abstract Overweight and obesity increase the risk of urinary incontinence.Please cite this paper as: Aune D, Mahamat-Saleh Y, Norat T, Riboli E. Body mass index, abdominal fatness, weight gain and the risk of urinary incontinence: a systematic review and dose-response meta-analysis of prospective studies.

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Section: Resultsmentioning

confidence: 54%

Body mass index, abdominal fatness, weight gain and the risk of urinary incontinence: a systematic review and dose–response meta‐analysis of prospective studies

Aune

Mahamat‐Saleh

Norat

et al. 2019

BJOG

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“…Further studies are needed to clarify whether and how fibre intake might interact with the microbiota in reducing diverticular disease risk. Dietary fibre is also associated with less adiposity and lower risk of overweight and obesity [46,47] and could, therefore, reduce the risk of diverticular disease indirectly, since overweight and obesity increase the risk [9]. However, most of the studies included in this analysis adjusted for BMI; thus, it seems that the observed association is largely independent of adiposity.…”

Section: Discussionmentioning

confidence: 92%

“…Collectively, these observations suggest that modifiable risk factors are of major importance for the development of diverticular disease. Overweight and obesity [9], low physical activity [9], smoking [10] and NSAID use [11] are established risk factors for diverticular disease.…”

Section: Introductionmentioning

confidence: 99%

Dietary fibre intake and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies

et al. 2019

Self Cite

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Background A high intake of dietary fibre has been associated with a reduced risk of diverticular disease in several studies; however, the dose-response relationship between fibre intake and diverticular disease risk has varied, and the available studies have not been summarised in a meta-analysis. We conducted a systematic review and meta-analysis of prospective cohort studies to clarify the association between dietary fibre intake, fibre subtypes, and the risk of diverticular disease. Methods PubMed and Embase databases were searched up to August 9th 2018. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model and nonlinear associations were modelled using fractional polynomial models. Results Five prospective cohort studies with 19,282 cases and 865,829 participants were included in the analysis of dietary fibre and diverticular disease risk. The summary RR was 0.74 (95% CI 0.71-0.78, I 2 = 0%) per 10 g/day. There was no evidence of a nonlinear association between dietary fibre intake and diverticular disease risk, p nonlinearity = 0.35, and there was a 23%, 41% and 58% reduction in risk for an intake of 20, 30, and 40 g/day, respectively, compared to 7.5 g/day. There was no evidence of publication bias with Egger's test, p = 0.58 and the association persisted in subgroup and sensitivity analyses. The summary RR per 10 g/day was 0.74 (95% CI 0.67-0.81, I 2 = 60%, n = 4) for cereal fibre, 0.56 (95% CI 0.37-0.84, I 2 = 73%, n = 2) for fruit fibre, and 0.80 (95% CI 0.45-1.44, I 2 = 87%, n = 2) for vegetable fibre. Conclusions These results suggest that a high fibre intake may reduce the risk of diverticular disease and individuals consuming 30 g of fibre per day have a 41% reduction in risk compared to persons with a low fibre intake. Further studies are needed on fibre types and risk of diverticular disease and diverticulitis.

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“…1,2 On the other hand, low physical activity and vitamin D deficiency are known as an emerging risk factor of this disease. 3,4 Vitamin D deficiency is highly prevalent; approximately 25%-57% of the US population 2 and more than 1 billion persons worldwide; 5,6 Also, the benefits of physical activity in the prevention and treatment of CAD have been very well described in adults. 6 Considering the high prevalence of decrease physical activity and vitamin D deficiency in Iran we investigated the prevalence of vitamin D deficiency in angioplasty patients, effect of physical activity and its relationship with coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

Links between low physical activity and vitamin D deficiency on coronary artery disease in patients undergoing coronary angiography

Hoseini¹,

Hoseini²

2018

JCCR

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Low physical activity and vitamin D deficiency are two risk factors in public health burdens accounting for most coronary artery disease (CAD) morbidity and mortality worldwide. The prevalence of CAD is increasing in the both men and women. Since the effect of physical activity and vitamin D on number of involved vessels in patients undergoing coronary angiography are unknown, studies needs to be done to combat this public health scourge.

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Body mass index and physical activity and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies

Cited by 72 publications

References 39 publications

Body mass index, abdominal fatness, weight gain and the risk of urinary incontinence: a systematic review and dose–response meta‐analysis of prospective studies

Body mass index, abdominal fatness, weight gain and the risk of urinary incontinence: a systematic review and dose–response meta‐analysis of prospective studies

Dietary fibre intake and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies

Links between low physical activity and vitamin D deficiency on coronary artery disease in patients undergoing coronary angiography

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