Body Mass Index and Locoregional Recurrence in Women with Early-Stage Breast Cancer

Warren, Laura; Ligibel, Jennifer A.; Chen, Yu Hui; Truong, Linh; Catalano, Paul J.; Bellon, Jennifer R.

doi:10.1245/s10434-016-5437-3

Cited by 29 publications

(32 citation statements)

References 41 publications

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“…This would allow us to carry out multidisciplinary interventions to prevent excess weight and a prevalence of obesity. Obesity is associated with lower survival rates in breast cancer (Druesne‐Pecollo et al., ), in postmenopausal cancer and in premenopausal cancer, as suggested by recent studies (Chan et al., ; Warren et al., ). It would seem that more studies are necessary with regard to the QoL of women with cancer with immediate breast reconstruction, taking other variables into account apart from the surgical variables.…”

Section: Discussionmentioning

confidence: 84%

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q^©

Cereijo-Garea

Pita-Fernández

Nebril

et al. 2018

Journal of Clinical Nursing

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Section: Discussionmentioning

confidence: 84%

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q^©

Cereijo-Garea

Pita-Fernández

Nebril

et al. 2018

Journal of Clinical Nursing

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“…Although the association between obesity/overweight and the prognosis of breast cancer patients remains controversial, it has been reported that impact of BMI on prognosis of breast cancer may relate to menopausal status. [ 15 ] To identify this issue, we conducted a stratified analysis according to the menopausal status.…”

Section: Discussionmentioning

confidence: 99%

“…According to previous study, the effects of higher BMI on prognosis of breast cancer may be associated with menopausal status. [ 15 ] Berclaz et al [ 9 ] demonstrated that elevated BMI is significantly associated with a worse prognosis of breast cancer, especially for premenopausal and perimenopausal patients, and Kawai et al [ 16 ] found that higher BMI (BMI ≥25.8 kg/m 2 ) was associated with an increase in mortality for premenopausal patients. In a cohort study, obese postmenopausal women at diagnosis were at increased risk of breast cancer mortality compared to normal weight women after 6-year follow-up, while being overweight did not affect survival.…”

Section: Introductionmentioning

confidence: 99%

Body mass index and prognosis of breast cancer

Sun¹,

Zhu²,

Qian³

et al. 2018

Medicine

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Objective:To examine whether obesity/overweight is a risk predictor for breast cancer recurrence and death by menopausal status in a retrospective study.Methods:We performed a retrospective analysis of 1017 breast cancer patients treated in our hospital from January 2004 to December 2012. Three groups were divided according to body mass index (BMI) when breast cancer diagnosis: normal weight, BMI < 25.0 kg/m2; overweight, 25.0≤BMI < 30.0 kg/m2; and obesity, BMI≥30.0 kg/m2. The clinicopathological characteristics and clinical outcomes of patients within 5 years following breast cancer diagnosed were analyzed. Subgroup analyses of BMI on breast cancer prognosis were analyzed according to the menopausal status when breast cancer diagnosis. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).Results:Overweight and obesity groups were associated with larger size tumors, older age, increased proportion of postmenopausal patients and less patients choosing anthracycline and/or taxane regimen. The 5-year disease-free survival (DFS) and overall survival (OS) decreased in overweight and obese patients (P < .001), and both overweight and obesity were independent predictors for increased risks of breast cancer relapse and death (P < .001). When stratified by menopausal status, both overweight and obesity were associated with reduced 5-year DFS and OS in postmenopausal patients (P < .050), and multivariate analysis showed that the risk of relapse and breast cancer mortality in these 2 groups also increased (P < .050). Among premenopausal patients, the risks of relapse and death were significantly increased in obesity group rather than overweight group by multivariate analysis.Conclusion:Overweight and obesity might be independently associated with poorer prognosis for breast cancer patients, and the effects of overweight on the breast cancer prognosis seem to be related to menopausal status.

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“…Associations between BMI and prognosis have already been demonstrated in some malignant tumors, primarily breast and prostate cancers. Patients with high BMIs at the time of breast cancer discovery have significantly increased risk of distant recurrence (21,22) and overall mortality (23). In one particular meta-analysis, higher BMI values were implicated in breast cancer incidence (24).…”

Section: Discussionmentioning

confidence: 99%

Optimal body mass index cut‑point for predicting recurrence‑free survival in patients with non‑muscle‑invasive urothelial carcinoma of bladder

et al. 2018

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In Japanese patients with non-muscle-invasive urothelial carcinoma of the bladder, the impact of body mass index (BMI) on recurrence following transurethral resection of bladder tumor (TURBT) is unclear. The present study retrospectively examined data collected from 50 patients diagnosed with primary urothelial carcinoma of the bladder (pTa, pTis, and pT1) who had previously undergone TURBT surgery. Two BMI cut-off points for predicting disease recurrence were evaluated: i) A threshold generated through receiver operating characteristic (ROC) curve analysis; ii) the World Health Organization BMI index (24 kg/m) for overweight status in Japanese populations. Univariate and multivariate analyses were applied to assess individual variables (BMI included) and the effect they had on recurrence-free survival (RFS). Median RFS and BMI values of 19.72 months (range, 3.13-72.13 months) and 23.37 kg/m2 (range, 14.72-36.84 kg/m2), respectively, were recorded. In multivariate analyses, higher continuous BMI was significantly associated with shorter RFS (P=0.019). Based on a ROC-generated BMI cut-off point (23.4 kg/m2), patients were ranked with either a high (≥23.4 kg/m2) or low (<23.4 kg/m2) BMI status. Multivariate analysis indicated that BMI values >23.4 kg/m2 were significantly associated with shorter RFS (P=0.028). Intravesical Bacillus Calmette-Guérin treatment and history of upper-tract urothelial carcinoma were also independently associated (P=0.044 and P=0.010, respectively). However, BMI values >24 kg/m2 (customary cut-off point) had no significant impact on RFS (P=0.066). Thus, a higher BMI status was revealed to be independently predictive of shorter RFS in Japanese patients undergoing TURBT for urothelial carcinoma of the bladder. A greater number of samples are required in order to determine optimal BMI cut-off points in Japanese patients and to investigate whether weight reduction intervention may improve prognosis.

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Body Mass Index and Locoregional Recurrence in Women with Early-Stage Breast Cancer

Abstract: For premenopausal women with invasive breast cancer who undergo BCT, BMI is an independent prognostic factor for LRR. If confirmed, these findings suggest that more aggressive treatment strategies may be warranted for these women.

Cited by 29 publications

References 41 publications

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q^©

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q^©

Body mass index and prognosis of breast cancer

Optimal body mass index cut‑point for predicting recurrence‑free survival in patients with non‑muscle‑invasive urothelial carcinoma of bladder

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Body Mass Index and Locoregional Recurrence in Women with Early-Stage Breast Cancer

Abstract: For premenopausal women with invasive breast cancer who undergo BCT, BMI is an independent prognostic factor for LRR. If confirmed, these findings suggest that more aggressive treatment strategies may be warranted for these women.

Cited by 29 publications

References 41 publications

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q©

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q©

Body mass index and prognosis of breast cancer

Optimal body mass index cut‑point for predicting recurrence‑free survival in patients with non‑muscle‑invasive urothelial carcinoma of bladder

Contact Info

Product

Resources

About

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q^©

Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST‐Q^©