Body mass index and knee osteoarthritis risk: A dose-response meta-analysis

Zhou, Zhenyu; Liu, Yake; Chen, Hong‐Lin; Liu, Fan

doi:10.1002/oby.20835

Cited by 65 publications

(41 citation statements)

References 25 publications

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“…Box plot distributions of baseline IL1Ra between non-progressors (JSN<0.0mm) and progressors (JSN >0.0; >0.2 and 0.5mm) are shown in Figure 1D. We also examined increased BMI as a risk factor for development of OA and progression 28,29 . We did not observe significant difference between the two BMI groups (below and above median BMI) with respect to mean medial JSW at 24 months (Table 5).…”

Section: Resultsmentioning

confidence: 99%

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Attur

Statnikov

Samuels

et al. 2015

Osteoarthritis and Cartilage

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Objective Pro- and anti-inflammatory mediators, such as IL-1β and IL1Ra, are produced by joint tissues in osteoarthritis (OA), where they may contribute to pathogenesis. We examined whether inflammatory events occurring within joints are reflected in plasma of patients with symptomatic knee osteoarthritis (SKOA). Design 111 SKOA subjects with medial disease completed a 24-month prospective study of clinical and radiographic progression, with clinical assessment and specimen collection at 6-month intervals. The plasma biochemical marker IL1Ra was assessed at baseline and 18 months; other plasma biochemical markers were assessed only at 18 months, including IL-1β, TNFα, VEGF, IL-6, IL-6Rα, IL-17A, IL-17A/F, IL-17F, CRP, sTNF-RII, and MMP-2. Results In cross-sectional studies, WOMAC (total, pain, function) and plasma IL1Ra were modestly associated with radiographic severity after adjustment for age, gender and BMI. In addition, elevation of plasma IL1Ra predicted joint space narrowing (JSN) at 24 months. BMI did associate with progression in some but not all analyses. Causal graph analysis indicated a positive association of IL1Ra with JSN; an interaction between IL1Ra and BMI suggested either that BMI influences IL1Ra or that a hidden confounder influences both BMI and IL1Ra. Other protein biomarkers examined in this study did not associate with radiographic progression or severity. Conclusions Plasma levels of IL1Ra were modestly associated with the severity and progression of symptomatic knee osteoarthritis in a causal fashion, independent of other risk factors. The findings may be useful in the search for prognostic biomarkers and development of disease-modifying OA drugs.

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Section: Resultsmentioning

confidence: 99%

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Attur

Statnikov

Samuels

et al. 2015

Osteoarthritis and Cartilage

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“…Obesity is known to be related to knee OA,2 3 and can be estimated from a person's body mass index (BMI). Higher BMI increases the risk of developing knee OA,4 and these data are clearly synthesised in previous systematic reviews 5 6. The patellofemoral (PF) joint is a dominant source of symptoms associated with knee OA 7.…”

Section: Introductionmentioning

confidence: 97%

Is body mass index associated with patellofemoral pain and patellofemoral osteoarthritis? A systematic review and meta-regression and analysis

et al. 2016

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“…1,2 As the prevalence of obesity in the United States remains elevated, 3 obesity-related knee OA is expected to rise. Although the mechanism linking obesity with the development and progression of OA is complex, one assumption remains that excess weight increases the mechanical load on the knee, leading to the degeneration of cartilage.…”

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confidence: 99%

Change in Physical Activity and Sedentary Time Associated With 2-Year Weight Loss in Obese Adults With Osteoarthritis

Pellegrini¹,

Song²,

Chang³

et al. 2016

Journal of Physical Activity and Health

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Background We examined if changes in moderate-to-vigorous physical activity (MVPA), light activity, and sedentary behavior are related to weight change over a 2-year period in obese adults with/elevated risk for knee osteoarthritis. Methods Weight, physical activity, and sedentary time at baseline and 2 years were obtained from 459 obese participants from the Osteoarthritis Initiative. Weight change was categorized as ≥ 10 lbs, 5.0 to 9.9 lbs, 4.9 to −4.9 lbs, −5.0 to −9.9 lbs, and ≤ −10 lbs. We examined the association between 2-year weight change categories and changes in activity/sedentary time from accelerometer monitoring by multiple linear regression adjusted for baseline weight, demographic, and health factors. Results Across the 5 weight categories (loss to gain), average 2-year change ranged from −7.4 to 28.0 sedentary minutes/ day, 4.2 to −23.1 light activity minutes/day, and 3.2 to −4.9 MVPA minutes/day, respectively. Higher weight loss categories were separately associated with increased MVPA (P for trend < 0.001) and less sedentary gain (P for trend = 0.01). Weight loss categories had a strong trend with light activity gain but not statistically significant (P for trend = 0.06). Conclusions Small increases in MVPA and decreases in sedentary time over 2 years were associated with weight loss among adults with obesity and with or at elevated risk for knee osteoarthritis.

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Body mass index and knee osteoarthritis risk: A dose-response meta-analysis

Abstract: The meta-analysis indicated that knee OA risk increased almost exponentially according with the increase of body mass index. Knee OA prevention will benefit from weight control.

Cited by 65 publications

References 25 publications

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Is body mass index associated with patellofemoral pain and patellofemoral osteoarthritis? A systematic review and meta-regression and analysis

Change in Physical Activity and Sedentary Time Associated With 2-Year Weight Loss in Obese Adults With Osteoarthritis

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