Body Mass Index and Hypertension Hemodynamic Subtypes in the Adult US Population

Chirinos, Julio A.; Franklin, Stanley S.; Townsend, Raymond R.; Raij, Leopoldo

doi:10.1001/archinternmed.2008.611

Cited by 56 publications

(46 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The significant association of IDH with obesity agrees with the findings of other studies (19,28). The association of smoking with IDH in this study is not in agreement with other studies which revealed no significant association of smoking with IDH (19,29). Smoking habits are self-expressed and are subject to bias recall.…”

Section: Discussionsupporting

confidence: 61%

Isolated Diastolic Hypertension among Adults in Saudi Arabia: Prevalence, Risk Factors, Predictors and Treatment. Results of a National Survey

Saeed

Al-Hamdan

2016

Balkan Med J

View full text Add to dashboard Cite

Background:In the past, diastolic hypertension was the main criterion for treatment, but currently, systolic pressure is the main criterion because it was thought that Isolated Diastolic Hypertension (IDH) is not associated with complications. Studies later revealed that IDH carries significant risks. Quantifying the magnitude and risk factors of IDH in the community is essential for all intervention strategies. Aims: This study aims to determine the prevalence, risk factors, predictors, treatment modalities and lifestyle practices of IDH adult patients in the Kingdom of Saudi Arabia (KSA). Study Design: Cross-sectional study. Methods: A community-based cross-sectional study using STEPwise approach among adults using a multistage, stratified, cluster random sample was carried out. Data were collected using questionnaires which included socio-demographics, blood pressure, biochemical, anthropometric measurements and lifestyle practices. Statistical analysis included calculating means and standard deviations, proportions, univariate and multiple logistic regression analysis. Results: Of a total 4562 subjects, 180 (3.95%) suffered from IDH, which was significantly related to age, gender, employment, smoking, diabetes mellitus, obesity and hypercholesterolemia. More than 93% were using some form of treatment, with 77.2% on prescribed drugs, 63% using diet, and 23% using exercise. Significant predictors of IDH were retirement and hypercholesterolemia. Conclusion: IDH is associated with some sociodemographic characteristics and co-morbidity. Given the risk of cardiovascular disease associated with IDH, the findings of this study emphasize the need for diagnosing the disease in middle-aged persons focusing on the modifiable risk factors of IDH.

show abstract

Section: Discussionsupporting

confidence: 61%

Isolated Diastolic Hypertension among Adults in Saudi Arabia: Prevalence, Risk Factors, Predictors and Treatment. Results of a National Survey

Saeed

Al-Hamdan

2016

Balkan Med J

View full text Add to dashboard Cite

show abstract

“…However, controversy exists over the type of blood pressure increase. Previous results showed that SBP represents the most prevalent type in obese women [34] , being a stronger predictor of CVD than DBP [35] . Indeed, these data are challenged by more recent research based on longitudinal studies [36] .…”

Section: Discussionmentioning

confidence: 94%

Hepatic steatosis in overweight/obese females: Newscreening method for those at risk

Tarantino¹,

Pizza²,

Colao³

et al. 2009

WJG

View full text Add to dashboard Cite

AIM:To identify which parameters could help to distinguish the "metabolically benign obesity", which is not accompanied by insulin resistance (IR) and early atherosclerosis. METHODS:Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine aminotransferase, blood pressure and the two imaging parameters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS:A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and significant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specificity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specificity 75%). CONCLUSION:As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better define subjects who really need to lose weight.

show abstract

“…It cannot be excluded that it is related to the influence of obesity on the prevalence of hypertension, which decreases with age. 30 As plasma visfatin/NAMPT levels were not assessed by ELISA in young obese patients with hypertension, this hypothesis cannot be verified. Finally, there are only few (mostly association) studies showing the correlation between lipid disturbances and circulating visfatin/NAMPT levels in subjects with MS. 31 Probably, it is the effect of microinflammation and IR related to obesity.…”

mentioning

confidence: 97%

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Kocełak¹,

Olszanecka-Glinianowicz²,

Owczarek³

et al. 2015

Polish Archives of Internal Medicine

View full text Add to dashboard Cite

IntroductIon Visceral adipose tissue is the main source of circulating proinflammatory adipokine, visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT), whose role in the pathogenesis of metabolic syndrome (MS) components such as hypertension and carbohydrate and lipid disturbances is still uncertain, due to commonly used low specific C-terminal immunoassays to determine visfatin/ NAMPT levels.objectIves The aim of the study was to assess the association between the occurrence of MS components and circulating visfatin/NAMPT levels in elderly population.PAtIents And methods The analysis included 2174 elderly participants of the PolSenior study without heart failure, severe chronic kidney disease, cancer, and malnutrition. MS was defined according to the modified International Diabetes Federation criteria. Plasma visfatin/NAMPT concentrations were measured by a highly specific enzyme-linked immunosorbent assay. Additionally, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and insulin levels were assessed, and the homeostasis model assessment for insulin resistance was calculated.results Women were diagnosed with MS more often than men (71.2% vs 56.8%; P <0.001) and had a greater prevalence of all MS components except for type 2 diabetes. Women with MS had higher concentrations of hsCRP and IL-6 than those without MS. Visfatin/NAMPT concentrations were higher in women with MS than in those without MS (1.06 ng/ml [0.65-1.87] vs 0.85 ng/ml [0.54-1.40]; P <0.001), but no differences were observed in men (0.97 ng/ml [0.59-1.61] vs 0.90 ng/ml [0.56-1.60], respectively; P = 0.5). In women, there was a stronger association between the number of components of MS and increased plasma visfatin/NAMPT levels than in men.conclusIons Plasma visfatin/NAMPT levels are increased only in elderly women with MS. It is difficult to distinguish the components of MS specifically associated with increased visfatin/NAMPT levels. 403assay (ELISA) kits in plasma samples of a large group of elderly subjects, participants of the PolSenior study, 18 may provide new data on the role of visfatin/NAMPT in MS. In our recently published study, we have shown that plasma visfatin/NAMPT levels are associated with age, systemic microinflammation, and IR regardless of sex, and with nutritional status only in women. 19 The aim of the present study was to assess the association between the number and type of MS components and circulating plasma visfatin/ NAMPT levels in elderly population.PAtIents And methods study design and setting This substudy was based on 2733 banked samples from the PolSenior study 18 stored at -70°C. The PolSenior study conducted in the years 2008 and 2011 recruited 6 age cohorts of a similar size (65-69 years, 70-74 years, 75-79 years, 80-84 years, 85-89 years, and ≥90 years). Trained nurses visited a total of 4979 participants 3 times to conduct a questionnaire survey, comprehensive geriatric assessment, and body mass, height, waist circumference, and blood pressure (BP) measurements. In addi...

show abstract

Body Mass Index and Hypertension Hemodynamic Subtypes in the Adult US Population

Cited by 56 publications

References 60 publications

Isolated Diastolic Hypertension among Adults in Saudi Arabia: Prevalence, Risk Factors, Predictors and Treatment. Results of a National Survey

Isolated Diastolic Hypertension among Adults in Saudi Arabia: Prevalence, Risk Factors, Predictors and Treatment. Results of a National Survey

Hepatic steatosis in overweight/obese females: Newscreening method for those at risk

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Contact Info

Product

Resources

About