Body Mass Index and Gonadotropin Hormones (LH & FSH) Associate With Clinical Symptoms Among Women With Polycystic Ovary Syndrome

Abstract

To evaluate the relevance of body mass index (BMI), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and LH/FSH ratio with clinical symptoms in polycystic ovary syndrome (PCOS) women.Methods:We reviewed the medical records of all women visited in the PCOS Clinic of Babol (Iran) from 2008 to 2012. A retrospective cross-sectional study was conducted on 175 PCOS women; aged 18–38 years diagnosed based on the Rotterdam criteria. Among the PCOs women, the prevalence of oligomenorrhea, acne, and hirsutism were found to be 92.0%, 31.4%, and 78.9%, respectively. Positive finding of polycystic ovaries was observed in 89.1% of PCOS women with by using sonography. A total of 69.2% overweight/obesity patients had polycystic ovary morphology on ultrasound image. Compared with non- overweight/obesity, the adjusted OR of PCOS women for sonographic view of polycystic ovaries was 4.33 (95% CI, 1.42-13.15, p=0.001), Nevertheless, the adjusted odds ratio (OR) showed no significant associations between LH, FSH, and LH/FSH ratio with clinical symptoms in these women. The findings of this study indicated that the overweight/obese women with PCOS are at an increased risk for sonographic view of polycystic ovaries. Therefore, it is suggested that successful weight loss is the most effective method of restoring ovulation, menstruation that should be used as major advice in obese PCOS patients.

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

“…When compared with the normal weight group, the underweight, overweight and obese groups exhibited a significant increase in DNA fragmentation rates. These results are consistent with those reported in previous studies (6–8). …”

“…Excessive weight is not only linked to an increased risk of developing chronic disease, but has also been demonstrated to increase the risk of developing reproductive disorders (8,22,23). The association between excessive weight and infertility has been established in females, but not in males.…”

“…The association between excessive weight and infertility has been established in females, but not in males. Females who are overweight or obese are more likely to experience ovulatory and menstrual disorders, and may experience delayed childbearing as a consequence (8). Several studies have investigated the association between BMI and different sperm parameters (24).…”

“…In recent years, an increasing number of reports have demonstrated a global trend indicating a significant deterioration in male reproductive function (3–5). In parallel, obesity rates are increasing rapidly worldwide (6,7), which is not only associated with an increased risk of developing chronic diseases, but has also been demonstrated to increase the risk of developing reproductive disorders (8). Due to the reported association between obesity and reproductive disorders, a greater clinical awareness and understanding of the underlying mechanisms of the effects of obesity on fertility are urgently required in order to determine the appropriate interventions.…”

Differences of correlations of echometric dimensions of the uterus in different phases of the menstrual cycle with constitutional parameters of the body in practically healthy young women of ecto- and mesomorphic somatotypes

“…Persons with chronic adnexitis, ovarian cysts, dysfunctional uterine bleeding differ from phenotypically healthy by distribution somatotypes and anthropometric indicators. Chronic adnexitis and dysfunctional uterine bleeding were prevalent in asthenics and transient asthenic somatotypes, and cystic ovarian lesions predominated in hypersthenic patients [8,9]. Chronic adnexitis and dysfunctional uterine bleeding were more common in women with low latitudinal (shoulder and pelvic width) and girth (shoulder, thigh) dimensions [27,28].…”