Body Mass Index and Diverticular Disease: A 28-Year Follow-Up Study in Men

Rosemar, Anders; Angerås, Ulf; Rosengren, Annika

doi:10.1007/s10350-007-9172-5

Cited by 141 publications

(127 citation statements)

References 31 publications

(32 reference statements)

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“…[21][22][23] Therefore, the aim in IS patients is to avoid diverticulitis. Smoking and obesity are known to increase the incidence of diverticulitis and complicated diverticulitis [24][25][26][27] ; in contrast physical activity prevents diverticulitis and reduces the risk of complicated diverticulitis. 28,29 The effects of nutrition habits on diverticulitis are controversial.…”

Section: Discussionmentioning

confidence: 99%

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Brandl

Kratzer

Kafka-Ritsch

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Brandl

Kratzer

Kafka-Ritsch

et al. 2016

cjs

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“…excessive flatulence and disordered, possibly aberrant, colonic motility. This is also true of the prospective study [65] in which the volunteers were not clinically examined for DD at baseline, so the study team had no way of knowing whether diverticula were present prior to this. Further, from their cohort of 43 881 male volunteers, aged between 45 and 75, they identified 362 new cases of self-reported symptomatic disease.…”

Section: Bread and Cereal Productsmentioning

confidence: 99%

“…A further confounding factor to these studies may be co-linearity (and also inverse linearity) in intake of other nutrients and dietary constituents with fiber consumption. For example, dietary fiber consumption may be inversely related to total energy consumption and hence adiposity [66] and there are independent studies linking an increasing BMI to an elevated risk for complicated DD [65,67] . Unfortunately, there appears to be no published data on obesity and asymptomatic DD.…”

Section: Bread and Cereal Productsmentioning

confidence: 99%

“…Unfortunately, there appears to be no published data on obesity and asymptomatic DD. Additional lifestyle risk factors emerging from the literature are: high red meat consumption [12,64] , increasing socio-economic status in a Greek cohort [12] , hypertension [65] , parity [12] and low physical activity with increased symptomatic disease [63] . The evidence base for these risk factors is even less vigorous than it is for dietary fiber.…”

Section: Bread and Cereal Productsmentioning

confidence: 99%

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Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Commane¹,

Arasaradnam²,

Mills³

et al. 2009

WJG

116

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Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.

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“…There were no significant differences between the three groups with respect to TG (Figure 3). (21), and obesity has been shown to play a role in the increasing incidence of colonic diverticulitis (11)(12)(13)(14)(15)(16)22). However, whether or not colonic diverticulosis is related to obesity remains a matter of controversy because of the limited number of relevant studies.…”

Section: Serum Lipid Profilesmentioning

confidence: 99%

The relationship between colonic diverticulosis and abdominal visceral and subcutaneous fat accumulation measured by abdominal CT scan

Lee

Ahn

Lee

et al. 2014

Turk J Gastroenterol

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Background/Aims: Besides age, risk factors for colonic diverticular disease include dietary meat intake and Western lifestyles, which are also risk factors for obesity. However, the association between obesity and colonic diverticular disease, including diverticulosis and diverticulitis, is not well established. The aim of this study was to investigate the relationship between colonic diverticulosis and obesity using abdominal fat quantified by abdominal CT scan and lipid profiles, as well as body mass index (BMI). Materials and Methods: In this study based on a retrospective case note review, we enrolled 133 subjects (control group (n=55), diverticulosis group (31), and diverticulitis group (47)). Abdominal fat areas (total abdominal fat, visceral fat, subcutaneous fat) were quantified by abdominal CT scan. Serum lipid profiles and BMI were checked. Statistical analysis was performed by independent t-tests, with significance set at p<0.05. Results: In the diverticulosis group, total abdominal fat area, visceral fat area, and abdominal subcutaneous fat area were all larger than those of the control and diverticulitis groups. In the diverticulitis group, total cholesterol, high density lipoprotein (HDL), low-density lipoprotein (LDL), and BMI were lower than in the control and diverticulosis groups. There were no significant differences between the three groups in visceral-to-subcutaneous abdominal fat ratios and serum triglyceride levels. Conclusion: In conclusion, obesity may predispose one to occurrence of colonic diverticulosis. Abdominal fat measurement by CT scan may be a good method of assessing risk of colonic diverticular disease.

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Body Mass Index and Diverticular Disease: A 28-Year Follow-Up Study in Men

Abstract: In a large community-based sample of middle-aged men, overweight and obesity were strongly linked to future severe diverticular disease leading to hospitalization.

Cited by 141 publications

References 31 publications

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

The relationship between colonic diverticulosis and abdominal visceral and subcutaneous fat accumulation measured by abdominal CT scan

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