Body Mass Index and Bromoxynil Exposure in a Sample of Rural Residents During Spring Herbicide Application

Semchuk, Karen M.; McDuffie, Helen H.; Cessna, Allan J.; Irvine, D.G.

doi:10.1080/15287390490471424

Cited by 13 publications

(4 citation statements)

References 42 publications

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“…The proper application of agrochemicals protects farm produce against diseases, pests, and weeds and should not pose any danger to consumers (Semchuk et al, 2004). In addition, food production has been changing for several years, with increasing attention being paid to using more crop protection products to enhance crop yields.…”

mentioning

confidence: 99%

Herbicide Residues and Nitrate Concentration in Tubers of Table Potatoes

Zarzecka¹,

Gugała²,

Mystkowska³

2010

Journal of Toxicology and Environmental Health, Part A

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This study examined Wiking-cultivar table potato tubers in a field experiment conducted between 2002 and 2004 using a rye complex soil. The experimental factors included (a) two methods of tillage, including traditional and simplified, as well as (b) seven methods of cultivation with the use of herbicides as follows: 1, control without herbicides; 2, Plateen 41.5 WG; 3, Plateen 41.5 WG + Fusilade Forte 150 EC; 4, Plateen 41.5 WG + Fusilade Forte 150 EC + adjuvant Atpolan 80 EC; 5, Barox 460 SL; 6, Barox 460 SL + Fusilade Forte 150 EC; and 7, Barox 460 SL + Fusilade Forte 150 EC + adjuvant Atpolan 80 EC. Determination of residues was performed using high-performance liquid and gas chromatography. Only trace quantities of bentazone (Barox 460 SL) were found in potato tubers, amounts that fell below the maximum residue limit (MRL). The nitrate content of potato tubers was determined using a nitrate ion-selective electrode and silver chloride reference electrode. The nitrate content in fresh matter of unpeeled and peeled tubers depended significantly only on weather conditions in the years of study. In contrast, agrotechnical procedures such as methods of tillage and cultivation did not significantly affect potato tuber nitrate content.

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mentioning

confidence: 99%

Herbicide Residues and Nitrate Concentration in Tubers of Table Potatoes

Zarzecka¹,

Gugała²,

Mystkowska³

2010

Journal of Toxicology and Environmental Health, Part A

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“…Levels of insecticide metabolite fipronil sulfone (detected in 35% of samples) were previously reported in human blood from the general population at concentrations varying between 0.1 and 4 ng/mL . Similarly, bromoxynil levels in plasma samples from teenagers residing in rural areas were previously reported from trace levels to 140 ng/mL . Likewise, previously reported levels of perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) (detection frequencies of 100 and 95%, respectively) in the German general population from 2009 to 2019 ranged from 0.9 to 9.9 ng/mL and from 0 to 4.6 ng/mL, respectively .…”

Section: Results and Discussionmentioning

confidence: 76%

“…40 Similarly, bromoxynil levels in plasma samples from teenagers residing in rural areas were previously reported from trace levels to 140 ng/mL. 41 Likewise, previously reported levels of perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) (detection frequencies of 100 and 95%, respectively) in the German general population from 2009 to 2019 ranged from 0.9 to 9.9 ng/mL and from 0 to 4.6 ng/mL, respectively. 42 As the MS1-based suspect screening approach allowed the annotation of all of these compounds, it appears that exogenous chemicals present at low levels in complex matrices may still be identified with a suspect screening strategy using Scannotation.…”

Section: Description Of Chemical Exposure Profiles In the Peĺagie Coh...mentioning

confidence: 79%

Scannotation: A Suspect Screening Tool for the Rapid Pre-Annotation of the Human LC-HRMS-Based Chemical Exposome

Chaker,

Gilles,

Monfort

et al. 2023

Environ. Sci. Technol.

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In an increasingly chemically polluted environment, rapidly characterizing the human chemical exposome (i.e., chemical mixtures accumulating in humans) at the population scale is critical to understand its impact on health. High-resolution mass spectrometry (HRMS) profiling of complex biological matrices can theoretically provide a comprehensive picture of chemical exposures. However, annotating the detected chemical features, particularly low-abundant ones, remains a significant obstacle to implementing such approaches at a large scale. We present Scannotation (), an automated and user-friendly suspect screening tool for the rapid pre-annotation of HRMS preprocessed data sets. This software tool combines several MS1 chemical predictors, i.e., m/z, experimental and predicted retention times, isotopic patterns, and neutral loss patterns, to score the proximity between features and suspects, thus efficiently prioritizing tentative annotations to verify. Scannotation and MS-DIAL4 were used to annotate blood serum samples of 75 Breton adolescents. Scannotation’s combination of MS1-based chemical predictors allowed us to annotate 89 chemically diverse environmental compounds with high confidence (confirmed by MS2 when available). These compounds included 62% of emerging molecules, for which no toxicological or human biomonitoring data are reported in the literature. The complementarity observed with MS-DIAL4 results demonstrates the relevance of Scannotation for the efficient pre-annotation of large-scale exposomics data sets.

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“…Five studies evaluated 2,4-D in blood (Knopp 1994;Knopp, Schmidt, and Niessner 1993;Kolmodin-Hedman and Erne 1980;Semchuk et al 2004Semchuk et al , 2003, but one (Knopp, Schmidt, and Niessner 1993) was excluded from further consideration as it was a case study of an unusually highly exposed individual (Table S6). Of the remaining studies, Semchuk et al (2003Semchuk et al ( , 2004 reported the use of different types of lab blanks (Tier 2); none of the studies documented the use of field blanks. Only Knopp (1994) provided information on sample storage time (Tier 2); none of the studies included assessments of analyte stability from time of sample collection through sample analysis.…”

Section: 4-d and Other Biomonitoring Matricesmentioning

confidence: 99%

Critical and systematic evaluation of data for estimating human exposures to 2,4-dichlorophenoxyacetic acid (2,4-D) – quality and generalizability

LaKind

Burns

Naiman³

et al. 2017

Journal of Toxicology and Environmental Health, Part B

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The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been commercially available since the 1940's. Despite decades of data on 2,4-D in food, air, soil, and water, as well as in humans, the quality the quality of these data has not been comprehensively evaluated. Using selected elements of the Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument (temporal variability, avoidance of sample contamination, analyte stability, and urinary methods of matrix adjustment), the quality of 156 publications of environmental- and biomonitoring-based 2,4-D data was examined. Few publications documented steps were taken to avoid sample contamination. Similarly, most studies did not demonstrate the stability of the analyte from sample collection to analysis. Less than half of the biomonitoring publications reported both creatinine-adjusted and unadjusted urine concentrations. The scope and detail of data needed to assess temporal variability and sources of 2,4-D varied widely across the reviewed studies. Exposures to short-lived chemicals such as 2,4-D are impacted by numerous and changing external factors including application practices and formulations. At a minimum, greater transparency in reporting of quality control measures is needed. Perhaps the greatest challenge for the exposure community is the ability to reach consensus on how to address problems specific to short-lived chemical exposures in observational epidemiology investigations. More extensive conversations are needed to advance our understanding of human exposures and enable interpretation of these data to catch up to analytical capabilities. The problems defined in this review remain exquisitely difficult to address for chemicals like 2,4-D, with short and variable environmental and physiological half-lives and with exposures impacted by numerous and changing external factors.

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Body Mass Index and Bromoxynil Exposure in a Sample of Rural Residents During Spring Herbicide Application

Cited by 13 publications

References 42 publications

Herbicide Residues and Nitrate Concentration in Tubers of Table Potatoes

Herbicide Residues and Nitrate Concentration in Tubers of Table Potatoes

Scannotation: A Suspect Screening Tool for the Rapid Pre-Annotation of the Human LC-HRMS-Based Chemical Exposome

Critical and systematic evaluation of data for estimating human exposures to 2,4-dichlorophenoxyacetic acid (2,4-D) – quality and generalizability

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