Body mass index and blood pressure in Korean men and women

Jones, Daniel W.; Kim, Joung S.; Andrew, Michael E.; Kim, Sung Joon; Hong, Young Pyo

doi:10.1097/00004872-199412000-00018

Cited by 180 publications

(88 citation statements)

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“…It has been hypothesized that obese individuals with BP o140/ 80 mmHg are actually 'hypertensive' relative to what their BP would be if they were lean. 5 This observation is supported by data which show a positive linear relationship between BP and body mass index even in the normotensive range, 6 and also by data demonstrating that obese-normotensive individuals almost always reduce BP when they lose weight. 7,8 In contrast, it is possible to study hypertension-independent effects of obesity on cardiovascular function with an animal model of diet-induced obesity, 9 by utilizing a longitudinal analysis wherein a pre-obese BP is determined and subsequently maintained during obesity development.…”

Section: Introductionmentioning

confidence: 67%

Hydralazine as antihypertensive therapy in obesity-related hypertension

2004

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OBJECTIVE:The objectives were two-fold: (1) determine whether the use of hydralazine as antihypertensive therapy during obesity development exacerbated obesity-related cardioacceleration and hormonal abnormalities; (2) determine whether the absence of hypertension in obesity attenuated obesity-related abnormalities in hemodynamics, cardiac hypertrophy, and hormonal profile. DESIGN: Female New Zealand White rabbits were divided into lean control (n ¼ 12), lean hydralazine-treated (n ¼ 9), obese control (n ¼ 11), and obese hydralazine-treated (n ¼ 8) groups. Pretreatment mean blood pressure (BP) and heart rate (HR) were determined using telemetry. Pretreatment BP was maintained during 12 weeks of obesity development using hydralazine. MEASUREMENTS: Chronically measured BP and HR; plasma/blood volume; wet and dry ventricular weights; body fat/water; and hormonal profile (plasma renin activity, aldosterone, cortisol, atrial natriuretic peptide, adrenaline, and noradrenaline). RESULTS: Hydralazine treatment in obese animals attenuated obesity-related renin-angiotensin system (RAS) activation. In contrast, RAS was activated in lean hydralazine, as indicated by increased plasma aldosterone. The absence of hypertension in obese hydralazine did not result in attenuation of cardioacceleration, cardiac hypertrophy, or intravascular volumes. CONCLUSIONS: Hydralazine treatment in obese rabbits did not exacerbate obesity-related cardiovascular and hormonal alterations. Cardioacceleration and cardiac hypertrophy persisted in obese hydralazine despite BP control, suggesting hypertension-independent effects of obesity on these variables. Hydralazine's effects on RAS activation differed in lean and obese rabbits, suggesting that the systemic effects of hydralazine as a control therapy in evaluation of antihypertensive medications may differ depending on the underlying pathology.

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Section: Introductionmentioning

confidence: 67%

Hydralazine as antihypertensive therapy in obesity-related hypertension

2004

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“…Moreover, this increased NO bioavailability in high-fat diet rats could represent an adaptive mechanism to counteract the reported detrimental outcome of excessive high-energy diet on vascular reactivity in obesity, mainly oxidative stress 25,26 . The improvement in endothelial NO pathway could also explain the absence of changes in blood pressure of obese rats, a parameter often reported to be increased in human and animal obesity 27,28 . These findings confirm the "obesity paradox" 6 and could help to understand the mechanisms responsible for this condition.…”

Section: Time (Min)mentioning

confidence: 94%

Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

Nascimento¹,

Baptista²,

Pereira³

et al. 2011

Arq. Bras. Cardiol.

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“…BMIs which are considered normal in non-Asian populations such as Caucasian, are predisposing factors to hypertension and type 2 diabetes mellitus in Asians such as Hong Kong or Korean populations. 5,6 Since satisfactory conclusions are not available on the association between BMI and cardiovascular risk factors in local towns in Japan, the author examined the relationship of BMI to blood pressure and the serum lipid levels in a rural Japanese population.…”

Section: Introductionmentioning

confidence: 99%

Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population

Kawada

2002

Int J Obes

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OBJECTIVE:The association between body mass index (BMI) and cardiovascular risk factors, widely recognized in Western populations, was evaluated on subjects living in a rural Japanese area. DESIGN: A cross-sectional survey. SUBJECTS: A total of 16 871 subjects aged 40 -59 y, from a rural area in Japan, participated in an annual health examination. All of the subjects were required to answer six items in a questionnaire on health behavior and provide blood samples. MEASUREMENTS: Quetelet's index, blood pressure, total cholesterol, high-density lipoprotein cholesterol, health practices on exercise, drinking and smoking. RESULTS: The mean BMI in the population was 23.1 AE 2.9. After adjustment for sex, age and six health habits, the BMI was found to be significantly associated with blood pressure and the serum lipid levels by multivariate logistic regression analysis. The adjusted odds ratio for hypertension ( ! 140=90 mmHg) against the lowest quartiles of BMI (separated by 20, 25 and 28) were 1.6, 2.8 and 5.2, respectively. The adjusted odds ratio for hypercholesterolemia ( ! 240 mg=dl) against the lowest quartiles of BMI were 2.1, 3.3 and 4.6, respectively. CONCLUSION: There was a significant relationship between the BMI and cardiovascular risk factors in a rural Japanese population. This association could be extended to lower BMI levels than those in Western populations.

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Body mass index and blood pressure in Korean men and women

Cited by 180 publications

References 0 publications

Hydralazine as antihypertensive therapy in obesity-related hypertension

Hydralazine as antihypertensive therapy in obesity-related hypertension

Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population

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