Objectives. To explore the coping strategies used following a lower limb amputation and their relationship to adjustment in the hospital, rehabilitation, and home setting. Method. Sixteen individuals who had a lower limb amputation due to vascular disease completed questionnaires, including the Ways of Coping Questionnaire (WCQ), during hospitalization (T1), at the end of rehabilitation (T2), and 2-3 months after discharge from rehabilitation (T3). A subsample (n = 10) also participated in three semistructured interviews analyzed using the approach of Miles and Huberman. Results. Self-controlling was the coping strategy used most, followed by seeking social support and positive reappraisal. Three additional coping strategies not found in the WCQ were identified in the qualitative data: noticing progress, learning new things, and using humor. Confrontive coping (T1) and escapeavoidance (T1, T2, and T3) were related to adjustment problems while positive reappraisal (T1 and T3), seeking social support (T1 and T3), and planful problem solving (T3) were associated with positive adjustment. Conclusion. Coping strategies used to deal with the amputation seem to vary across settings, thus signifying the complexity of the coping process following a lower limb amputation due to vascular disease.