1990
DOI: 10.1007/bf01093454
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Body fluid status on induction, reinduction and prolonged stay at high altitude of human volunteers

Abstract: Studies on adaptation to high altitude (HA) of 3500 m in the Himalayas were conducted in three phases, each including 10 normal and healthy males normally resident at sea-level. Phase I subjects had no previous experience of HA, phase II subjects after 4-6 months at HA were airlifted to sea-level and phase III subjects stayed continuously for 6 months at 3500 m. Body fluid compartments and blood gases were determined in all three groups. Plasma volume was highly elevated in the phase II subjects on reinduction… Show more

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Cited by 28 publications
(22 citation statements)
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“…On the other hand the inverse correlation (r = -0.689, P = 0.0138) between the increase in urine flow and the mean S a O 2 at 4500 m might point to a crucial role of the arterial hypoxaemia in determining the amount of high altitude diuresis. Assuming that the observed loss of body mass mainly reflects body fluid loss, the results would imply a negative water balance, a finding also reported in other high altitude studies, which, in particular, have demonstrated a reduction in interstitial fluid and plasma volume (Frayser et al 1975;Singh et al 1990). In our experiments, the mean renal fluid loss during the whole hypoxia exposure (484 ml) would suggest, that in addition there must have been an increase in the insensible water loss, i.e.…”
Section: Diuresismentioning
confidence: 72%
“…On the other hand the inverse correlation (r = -0.689, P = 0.0138) between the increase in urine flow and the mean S a O 2 at 4500 m might point to a crucial role of the arterial hypoxaemia in determining the amount of high altitude diuresis. Assuming that the observed loss of body mass mainly reflects body fluid loss, the results would imply a negative water balance, a finding also reported in other high altitude studies, which, in particular, have demonstrated a reduction in interstitial fluid and plasma volume (Frayser et al 1975;Singh et al 1990). In our experiments, the mean renal fluid loss during the whole hypoxia exposure (484 ml) would suggest, that in addition there must have been an increase in the insensible water loss, i.e.…”
Section: Diuresismentioning
confidence: 72%
“…It is reported that about 3.5% of total body water decreases during first 3 days of HA (3500 m) exposure. But this body water loss is in proportion to the decrease in body weight (Jain et al 1980;Singh et al 1990). The decrease in food intake and loss in body mass in the present study is similar as reported earlier by several other workers.…”
Section: Discussionmentioning
confidence: 98%
“…Lowlanders who sojourn to a high altitude often develop a transient increase in erythrocyte concentration, but this is caused by a reduced plasma volume because of high altitude dehydration, and not an increased rate of erythrocyte production [52].…”
Section: Role Of Quercetin In Modulating Hematological Changesmentioning
confidence: 99%