Body fluid oxygen tension and prognosis in patients with ruptured aneurysm.

Abstract

SUMMARY Body fluid gas pressure and electrolytes of patients with ruptured aneurysm were continuously analyzed. Intracranial pressure (ICP) was regulated at the level of 120-100 mm H 2 O by cerebral ventricular drainage. There was no significant change in the pH, Pco 2 , Hco;, Na + , K + , Ca + + in the cerebrospinal fluid (CSF) of patients with slight or moderate disturbance of consciousness (lethargic-drowsy state). The P C5f o 2 of the patients with marked disturbances of consciousness (semicoma-coma) was significantly low. P c »rO 2 of the patients with cerebral vasospasm was significantly lower than for those without vasospasms. P C8 rO 2 /Pao 2 was 0.27 ± 0.01 in the patients with vasospasm and 0.50 ± 0.01 in those with vasospasm. P C8f o 2 tended to decrease in patients with markedly bloody CSF. When the bloody CSF was cleared by ventricular drainage, P CBf o 2 increased. P CB fO 2 did not return to a normal value in the patients with marked disturbances of consciousness despite sufficient arterial oxygen tension. This suggests that P car o 2 and P CBf o 3 /Pao 2 should provide a convenient index for the prognosis of patients with ruptured aneurysm.

Mechanisms of extramedullary relapse in acute lymphoblastic leukemia: Reconciling biological concepts and clinical issues

“…There are few clues in the literature to estimate the oxygen tension of subarachnoidal tissue, where ALL cells preferentially settle. Some studies have evaluated the oxygen tension within the CSF, with estimated values of approximately 5 to 6% [154,155]. More recently, Sharan et al showed that oxygen tension decreases rapidly from pial vessels to the extravascular space in a rodent model, with oxygen levels as low as 3% 30…”