Abstract:Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that the prothoracic gland in Drosophila larvae monitors peripheral fat for sexual maturation commitment via semaphorin 1a (Sema1a). Larvae with prothoracic gland knockdown of Sema1a do not mature, and continue to grow excessively. The same phenotype occurs after reducing the lipid carrier ApoB/lipophorin in the fat body. Super-resolution imaging revealed that at critical weight, an endoplasmic reticulum traf… Show more
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