Body Fat, Resting and Exercise Blood Pressure and the Angiotensinogen M235T Polymorphism: The Heritage Family Study

Rankinen, Tuomo; Gagnon, Jacques; Pérusse, Louis; Rice, Treva; Leon, Arthur S.; Skinner, James S.; Wilmore, Jack H.; Rao, D. C.; Bouchard, Claude

doi:10.1002/j.1550-8528.1999.tb00429.x

Cited by 38 publications

(20 citation statements)

References 35 publications

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“…The increased expression of AGT is an important characteristic of preadipocyte differentiation, especially because Ang II has a fundamental role in this process. It was previously demonstrated that AGT expression is elevated in obesity (20,21). Zucker rats show an increased expression and secretion of AGT in adipocytes (22).…”

Section: Discussionmentioning

confidence: 97%

Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism

Santos

Fernandes²,

Mario³

et al. 2008

Diabetes

224

184

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OBJECTIVE-Metabolic syndrome is characterized by the variable coexistence of obesity, hyperinsulinemia, insulin resistance, dyslipidemia, and hypertension. It is well known that angiotensin (Ang) II is importantly involved in the metabolic syndrome. However, the role of the vasodilator Ang-(1-7)/Mas axis is not known. The aim of this study was to evaluate the effect of genetic deletion of the G protein-coupled receptor, Mas, in the lipidic and glycemic metabolism in FVB/N mice. RESULTS-Despite normal body weight, Mas-knockout (Mas-KO) mice presented dyslipidemia, increased levels of insulin and leptin, and an ϳ50% increase in abdominal fat mass. In addition, Mas gene-deleted mice presented glucose intolerance and reduced insulin sensitivity as well as a decrease in insulin-stimulated glucose uptake by adipocytes and decreased GLUT4 in adipose tissue. Mas Ϫ/Ϫ presented increased muscle triglycerides, while liver triglyceride levels were normal. Expression of TGF-␤ and AGT genes was higher in Mas-KO animals in comparison with controls. RESEARCH DESIGN AND METHODS-Plasma CONCLUSIONS-These results show that

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Section: Discussionmentioning

confidence: 97%

Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism

Santos

Fernandes²,

Mario³

et al. 2008

Diabetes

224

184

View full text Add to dashboard Cite

show abstract

“…33 Others also have reported interactions between body fat, blood pressure, and AGT genotype. 34 The lack of sympathetic nervous system effects on adrenal aldosterone production may explain the absence of an association between BMI and adrenal response. Although multiple factors affected renal vascular response, AGT genotype and sex were associated primarily with adrenal response in our study.…”

Section: Discussionmentioning

confidence: 99%

Angiotensinogen Genotype Affects Renal and Adrenal Responses to Angiotensin II in Essential Hypertension

et al. 2002

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Background — Renovascular and adrenal responses to infused angiotensin II (Ang II) are intermediate phenotypes that may indirectly reflect tissue renin-angiotensin system activity. We examine herein angiotensinogen ( AGT ) as a candidate gene to help elucidate potential mechanisms for previously reported AGT linkage and association studies. Methods and Results — Renal plasma flow and plasma aldosterone were measured before and after a 45-minute infusion of Ang II (3 ng · kg −1 · min −1 ) in 190 hypertensive patients who were on carefully controlled high- and low-salt diets. Reduced renal vascular ( P =0.0002) and adrenal ( P =0.002) responses to infused exogenous Ang II were associated with the AGT −6A allele. In multiple logistic regression, greater body mass index, lower basal renal plasma flow, and higher diastolic blood pressure together with AGT −6A genotype were associated with lower renal vascular response. In contrast, only male sex and AGT −6A genotype were associated with lower adrenal response. When both the renal and adrenal responses to Ang II were in the lowest tertile, the AGT −6AA genotype was present in 55.6%; in contrast, when both responses were in the upper 2 tertiles, the −6AA genotype was present in only 17.8% ( P =0.001). Conclusions — A clear association between AGT genotype and response to infused Ang II was demonstrated for both the renal vasculature and the adrenal, consistent with the hypothesis that the AGT −6A genotype results in increased tissue expression of angiotensinogen and Ang II.

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“…In the HERITAGE Family Study, resting blood pressures were measured using Colin STBP-780 automated units (San Antonio, TX, USA) and the recordings were confirmed by technicians wearing ear phones. 20,38 Resting blood pressure was obtained on two separate days before 11:00 am in the post-absorptive state and with no caffeine-containing beverages or tobacco products for at least 2 h before assessment. Measurements were performed in a quiet room at neutral ambient temperature (24 -25 C) with the lights dimmed.…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

Is adiposity at normal body weight relevant for cardiovascular disease risk?

et al. 2002

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OBJECTIVE:To examine the relation between adiposity and risk factors for cardiovascular disease (CVD) in normal weight (NW) individuals. METHODS: Cross-sectional study using the sample of white people, aged from 17 to 60 y from the Québec Family Study and the Heritage Family Study. NW subjects with a body mass index (BMI) between 18.5 and 25 kg=m 2 (181 males and 265 females) and overweight (OW) subjects with a BMI between 25 and 30 kg=m 2 (133 males and 114 females) were retained for this study. NW subjects were divided into quintiles of each adiposity variable, then the quintiles and the OW group were evaluated for the presence of CVD risk factors. Using logistic regression analysis, the odds ratio (OR) for the prevalence of risk factors for each quintile of each adiposity variable and the OW group was estimated relative to the first quintile in NW subjects. Mean values of adiposity variables were compared between the subjects with and without risk factors. In these analyses, age and study cohort effects were taken into account. MEASUREMENTS: Percentage body fat (%fat) and fat mass (FM) measured by underwater weighing were available as adiposity variables. Risk factors included systolic and diastolic blood pressure, LDL and HDL cholesterol, triglycerides and fasting glucose. RESULTS: Wide ranges of values were observed for adiposity variables. HDL cholesterol, triglycerides and fasting glucose in NW males and HDL cholesterol in NW females were significantly correlated with all adiposity variables. For males, higher quintiles of adiposity variables in the NW group and the OW group tended to have higher ORs compared to the first quintiles for the risk factor variables. The fifth quintiles of all adiposity variables had the highest ORs (3.15 for %fat and 3.77 for FM) and they were significantly different from the first quintiles. OW males had ORs similar to those of the fifth quintiles for the risk factor variables. On the other hand, for females, the relatively linear associations were less clear in the NW group. In NW males, the subjects with at least one risk factor had significantly higher %fat and FM than the subjects without risk factors. In NW females, no significant difference was observed for these adiposity variables between the subjects with and without risk factors. CONCLUSION: NW males with elevated adiposity had higher prevalence of risk factors than NW males with less adiposity and the prevalence in the former was rather similar to that seen in OW males. On the other hand, measures of adiposity added little additional information to the BMI classification of NW on CVD risk factors in females.

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Body Fat, Resting and Exercise Blood Pressure and the Angiotensinogen M235T Polymorphism: The Heritage Family Study

Cited by 38 publications

References 35 publications

Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism

Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism

Angiotensinogen Genotype Affects Renal and Adrenal Responses to Angiotensin II in Essential Hypertension

Is adiposity at normal body weight relevant for cardiovascular disease risk?

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