Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults – the Lifestyle, Biomarkers, and Atherosclerosis study

Pettersson-Pablo, Paul; Nilsson, Torbjörn; Breimer, Lars H.; Hurtig-Wennlöf, Anita

doi:10.1080/00365513.2019.1576219

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…The link between autophagy, TNF-α expression and CaSR is consistent with our previous findings where CaSR-induced autophagy in preadipocytes mediated TNF- α secretion [ 3 ]. Our model indicates that CaSR could mediate the association between obesity and autophagy in AT that has been consistently documented [ 2 , 7 , 30 , 47 ]. These findings support the idea that even though autophagy and inflammation are regulated and necessary for cellular homeostasis, when dysregulated they become pathological.…”

Section: Discussionsupporting

confidence: 72%

“…Adipocytes in vitro show elevated CaSR expression when exposed to proinflammatory cytokines or serum from donors with obesity [ 15 ]. Interestingly, we observed that CaSR mRNA in AT explants was positively correlated with %BF, which in addition to being an obesity indicator, is strongly associated with low-grade inflammation [ 30 ]. Together, these data fuel the hypothesis that CaSR could play an important role in perpetuating the inflammatory and dysfunctional state of AT.…”

Section: Discussionmentioning

confidence: 99%

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Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy

Mattar

Sanhueza

Yuri

et al. 2020

IJMS

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Autophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that activation of the calcium-sensing receptor (CaSR) elevates proinflammatory cytokines through autophagy in preadipocytes. Our aim is to understand the role of CaSR on autophagy in AT from humans with obesity. We determined mRNA and protein levels of CaSR and markers of autophagy by qPCR and western blot in human visceral AT explants or isolated primary preadipocytes (60 donors: 72% female, 23–56% body fat). We also investigated their association with donors’ anthropometric variables. Donors’ % body fat and CaSR mRNA expression in AT were correlated (r = 0.44, p < 0.01). CaSR expression was associated with mRNA levels of the autophagy markers atg5 (r = 0.37, p < 0.01), atg7 (r = 0.29, p < 0.05) and lc3b (r = 0.40, p < 0.01). CaSR activation increased becn and atg7 mRNA expression in AT. CaSR activation also upregulated LC3II by ~50%, an effect abolished by the CaSR inhibitor. Spermine (CaSR agonist) regulates LC3II through the ERK1/2 pathway. Structural equation model analysis suggests a link between donors’ AT CaSR expression, AT autophagy and expression of Tumor Necrosis Factor alpha TNF-α. CaSR expression in visceral AT is directly associated with % body fat, and CaSR activation may contribute to obesity-related disruption in AT autophagy.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy

Mattar

Sanhueza

Yuri

et al. 2020

IJMS

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“…Age, sex, total number of steps, parental education, Tanner stage, and energy intake qualified as covariates for the multivariable model (model 1). As FM is a strong predictor of the assessed biological markers [ 21 ], FM was included as a covariate in a separate model (model 2) in addition to the covariates considered in model 1. In all models, potential interactions were tested and partial eta-squared (effect size) was calculated to determine the strength of the association between the independent and dependent variables.…”

Section: Methodsmentioning

confidence: 99%

The Associations between Dairy Product Consumption and Biomarkers of Inflammation, Adipocytokines, and Oxidative Stress in Children: A Cross-Sectional Study

et al. 2020

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The association between dairy product consumption and biomarkers of inflammation, adipocytokines, and oxidative stress is poorly studied in children. Therefore, these associations were examined in a representative subsample of 1338 schoolchildren with a mean age of 11.5 (±0.7) years in the Healthy Growth Study. Information on dairy product consumption was collected by dietary recalls. Total dairy consumption was calculated by summing the intake of milk, yogurt, and cheese. Inflammatory markers, i.e., high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and adipocytokines, i.e., leptin, adiponectin, and the antioxidant enzyme glutathione peroxidase (GPx) were analysed. Due to the skewed distribution hs-CRP, IL-6, and leptin were log transformed. Multivariable regression analyses adjusted for age, sex, energy intake, physical activity, parental education, Tanner stage, and fat mass were used to assess the associations between consumption of total dairy, milk, yogurt, cheese, and markers of inflammation, adipocytokines, oxidative stress, and adiponectin−leptin ratio. Our results showed that milk consumption was inversely associated with leptin (β: −0.101; 95% CI: −0.177, −0.025, p = 0.009) and positively associated with the adiponectin−leptin ratio (β: 0.116; 95% CI: 0.020, 0.211; p = 0.018), while total dairy, cheese, and yogurt consumption were not associated with inflammatory, adipocytokine, or antioxidant markers. Further prospective studies are needed to confirm these results.

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“…Studies examining the effect of exogenously administered estrogen on vascular measurements have yielded conflicting results [16][17][18][19], and have not examined young populations. Exogenously administered estrogen is previously known to affect baseline levels of markers of systemic inflammation [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Pettersson-Pablo

Cao

Bäckström

et al. 2020

BMC Cardiovasc Disord

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Background: Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults. Methods: Pulse-wave velocity (PWV), carotid-intima media thickness (cIMT) and augmentation index (AIX) were measured in 834 healthy non-smokers (ages 18.0-25.9). Emphasis was put on discriminating between individuals having a vascular structure and function associated with a higher or lower risk, and cluster analysis algorithms were employed to assign the subjects into groups based on these vascular measurements. In addition, a vascular status score (VSS) was calculated by summarizing the results according to quintiles of the vascular measurements. The associations between VSS and cardiovascular biomarkers were examined by regression analyses. Results: The cluster analyses did not yield sufficiently distinct clustering (groups of individuals that could be categorized unequivocally as having either a vascular structure and function associated with a higher or lower CVD risk). VSS proved a better classificatory variable. The associations between VSS and biomarkers of cardiovascular risk were analyzed by univariable and multivariable regressions. Only body fat percentage and C-reactive protein (CRP) were independently associated with VSS. Conclusions: A VSS calculation, which integrates PWV, cIMT, and AIX measurements is better suited for cardiovascular risk evaluation in young adults than cluster analyses. The independent associations of VSS with body fat percentage and CRP highlight the decisive role of adiposity and systemic inflammation in early atherosclerotic progression and suggests a subordinate role of insulin and lipid metabolism in this age span.

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Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults – the Lifestyle, Biomarkers, and Atherosclerosis study

Abstract: Hurtig-Wennlöf (2019) Body fat percentage is more strongly associated with biomarkers of lowgrade inflammation than traditional cardiometabolic risk factors in healthy young adults-the Lifestyle, Biomarkers, and Atherosclerosis study,

Cited by 14 publications

References 31 publications

Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy

Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy

The Associations between Dairy Product Consumption and Biomarkers of Inflammation, Adipocytokines, and Oxidative Stress in Children: A Cross-Sectional Study

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

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