Body fat percentage is associated with cardiometabolic dysregulation in BMI-defined normal weight subjects

Shea, Jennifer; King, Michael; Yi, Yanqing; Gulliver, Wayne; Sun, Guang

doi:10.1016/j.numecd.2010.11.009

Cited by 148 publications

(128 citation statements)

References 21 publications

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“…or bioelectrical impedance analysis (Shea et al 2012). However, there is still no consensus as to what level of body fat defines obesity in women or men.…”

Section: :1mentioning

confidence: 99%

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Jafarinasabian

Inglis

Reilly

et al. 2017

Journal of Endocrinology

195

147

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Aging affects almost all physiological processes, but changes in body composition and body phenotype are most observable. In this review, we focus on these changes, including loss of bone and muscle and increase in body fat or redistribution of the latter, possibly leading to osteosarcopenic obesity syndrome. We also address low-grade chronic inflammation, prevalent in aging adults and a cause of many disorders including those associated with body composition. Changes in dietary intake and nutritional requirements of older individuals, that all may lead to some disturbances on tissue and organ levels, are discussed as well. Finally, we discuss the hormonal changes in the aging body, considering each of the tissues, bone, muscle and fat as separate endocrine organs, but yet in the continuous interface and communication with each other. Although there are still many unanswered questions in this field, this review will enable the readers to better understand the aging human body and measures needing to be implemented toward reducing impaired health and disability in older individuals.

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“…or bioelectrical impedance analysis (Shea et al 2012). However, there is still no consensus as to what level of body fat defines obesity in women or men.…”

Section: :1mentioning

confidence: 99%

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Jafarinasabian

Inglis

Reilly

et al. 2017

Journal of Endocrinology

195

147

View full text Add to dashboard Cite

show abstract

“…First, we performed a retrospective cohort 9,548 lung transplants performed in the US after initiation of the Lung Allocation Score on (3,20). Because of few subjects in class III (n = 9) we collapsed classes II and III into class II-III.…”

Section: Data Sources Participants and Study Designmentioning

confidence: 99%

“…BMI misclassifies 39% of healthy adults as nonobese when compared with methods that define obesity by adipose tissue mass, such as wholebody dual X-ray absorptiometry (DXA) (7)(8)(9). BMI is a relatively poor measure of adiposity and sarcopenia (low muscle mass), both inflammatory states (10,11) associated with mortality (12,13).…”

mentioning

confidence: 99%

Body Composition and Mortality after Adult Lung Transplantation in the United States

Singer¹,

Peterson²,

Snyder³

et al. 2014

Am J Respir Crit Care Med

113

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Rationale: Obesity and underweight are contraindications to lung transplantation based on their associations with mortality in studies performed before implementation of the lung allocation score (LAS)-based organ allocation system in the United States Objectives: To determine the associations of body mass index (BMI) and plasma leptin levels with survival after lung transplantation.Methods: We used multivariable-adjusted regression models to examine associations between BMI and 1-year mortality in 9,073 adults who underwent lung transplantation in the United States between May 2005 and June 2011, and plasma leptin and mortality in 599 Lung Transplant Outcomes Group study participants. We measured body fat and skeletal muscle mass using whole-body dual X-ray absorptiometry in 142 adult lung transplant candidates.Measurements and Main Results: Adjusted mortality rates were similar among normal weight (BMI 18.5-24.9 kg/m 2 ), overweight , and class I obese (BMI 30-34.9) transplant recipients. Underweight (BMI , 18.5) was associated with a 35% increased rate of death (95% confidence interval, 10-66%). Class II-III obesity (BMI > 35 kg/m 2 ) was associated with a nearly twofold increase in mortality (hazard ratio, 1.9; 95% confidence interval, 1.3-2.8). Higher leptin levels were associated with increased mortality after transplant surgery performed without cardiopulmonary bypass (P for interaction = 0.03). A BMI greater than or equal to 30 kg/m 2 was 26% sensitive and 97% specific for total body fat-defined obesity.Conclusions: A BMI of 30.0-34.9 kg/m 2 is not associated with 1-year mortality after lung transplantation in the LAS era, perhaps because of its low sensitivity for obesity. The association between leptin and mortality suggests the need to validate alternative methods to measure obesity in candidates for lung transplantation. A BMI greater than or equal to 30 kg/m 2 may no longer contraindicate lung transplantation.

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“…According to Thomas et al, these individuals demonstrate a higher ratio of visceral and subcutaneous abdominal adipose tissue [21]. According to Shea et al, individuals with normal weight belonging to this phenotype have been associated with an increased waist circumference and body fat [25,30].…”

Section: Metabolically Obese Normal-weight (Monw)mentioning

confidence: 99%

Obesity phenotypes: normal-weight individuals with metabolic disorders versus metabolically healthy obese

Cembrowska

Stefańska

Odrowąż-Sypniewska

2017

Medical Research Journal

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According to recent studies, adipose tissue secretes a large number of bioactive proteins, which affect the whole body metabolism. The amount of adipose tissue is the main factor that explains metabolic disorders; however, obesity is not necessarily the result of increased body weight. Interestingly, there is a subgroup of patients with normal weight and high-risk metabolic profile. Consequently, they are significantly more likely to have metabolic disorders or cardiovascular disease (CVD). Conversely, some individuals, called metabolically healthy obese (MHO), demonstrate a favourable metabolic profile despite having high BMI index and excessive adipose tissue.The aim of this paper is to review recent studies about obesity phenotypes. Better understanding of differences between metabolically obese normal-weight (MONW) and MHO may improve the therapy and treatment of metabolic health in all obese patients. Equally importantly, it may lead to an increase in early detection of individuals with metabolic disorders, regardless of their body mass value or BMI.

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Body fat percentage is associated with cardiometabolic dysregulation in BMI-defined normal weight subjects

Cited by 148 publications

References 21 publications

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Body Composition and Mortality after Adult Lung Transplantation in the United States

Obesity phenotypes: normal-weight individuals with metabolic disorders versus metabolically healthy obese

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