Body fat index: A novel alternative to body mass index for prediction of gestational diabetes and hypertensive disorders in pregnancy

Nassr, Ahmed A.; Shazly, Sherif; Trinidad, Mari Charisse; El-Nashar, Sherif A.; Marroquin, Amber M.; Brost, Brian C.

doi:10.1016/j.ejogrb.2018.07.001

Cited by 20 publications

(28 citation statements)

References 16 publications

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“…In this light, WC is a more practical measure for maternal central obesity, consistent with six of the studies included in our analysis. In addition, two included studies [22,23] used BFI and FMP measured using bioelectrical impedance to evaluate maternal central obesity and had high heterogeneity (I 2 = 81:5, P = 0:02). Of note, one study found a positive correlation between increasing FMP and the risk of GDM in overweight and obese women, and the OR increased 8.8-fold in the highest quartile of FMP compared with the lowest quartile [23].…”

Section: Discussionmentioning

confidence: 99%

“…From the included studies, 2,226 and 25,449 pregnant women were GDM and non-GDM, respectively. A total of seven studies were from non-Asian countries [14,[16][17][18][20][21][22], and four were from Asia [13,15,19,23].…”

Section: Characteristics and Quality Assessment Of Includedmentioning

confidence: 99%

“…The GDM was diagnosed based on two methods among all the studies: five studies used Carpenter/Coustan diagnostic criteria [17-19, 21, 22], five studies used WHO screening criteria (75 g oral glucose tolerance test) [17-19, 21, 22], and one study used self-reports [16]. In these studies, nine studies reported the relationship between maternal central obesity and GDM in the first trimester [13][14][15][16][18][19][20][21] and two reported the relationship in the second trimester [22,23]. Six studies adopted WC or WHR [13][14][15][16][17][18], two used visceral adipose tissue depth (VAT) [20,21], two used BFI or FMP [22,23], and one used maternal SFT to measured maternal central obesity [19].…”

Section: Characteristics and Quality Assessment Of Includedmentioning

confidence: 99%

“…Hence, maternal central obesity is significant and can reflect fat distribution or the proportion of adipose to nonadipose tissue [12]. Existing research shows that maternal central obesity has many evaluation measures, such as waist circumference (WC)/waist-hip ratio (WHR) [13][14][15][16], abdominal subcutaneous fat thickness (SFT) [17][18][19][20][21], and body fat index (BFI) [22,23], but the predictive value of these measures is not clear. The measurement accuracy and precision of WC are difficult to guarantee as it can only evaluate the condition of abdominal fat tissue, which has certain limitations [24,25].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Maternal Central Obesity and the Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies

Yao

Chang

et al. 2020

Journal of Diabetes Research

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Objective. Nowadays, body mass index (BMI) is used to evaluate the risk stratification of obesity-related pregnancy complications in clinics. However, BMI cannot reflect fat distribution or the proportion of adipose to nonadipose tissue. The objective of this study is to evaluate the association of maternal first or second trimester central obesity with the risk of GDM. Research Design and Methods. We searched in PubMed, Embase, and Web of Science for English-language medical literature published up to 12 May 2019. Cohort studies were only included in the search. Abdominal subcutaneous fat thickness, waist circumference, waist-hip ratio or body fat distribution were elected as measures of maternal central obesity, and all diagnostic criteria for GDM were accepted. The random effect meta-analysis was performed to evaluate the relationship between central obesity and the risk of GDM. Results. A total of 11 cohort studies with an overall sample size of 27,675 women and 2,226 patients with GDM were included in the analysis. The summary estimate of GDM risk in the central obesity pregnant women was 2.76 (95% confidence interval [CI]: 2.35–3.26) using the adjusted odds ratio (OR). The degree of heterogeneity among the studies was low (I2=14.4, P=0.307). The subgroup analyses showed that heterogeneity was affected by selected study characteristics (methods of exposure and trimesters). After adjusting for potential confounds, the OR of adjusted BMI was significant (OR=3.07, 95% CI: 2.35–4.00). Conclusions. Our findings indicate that the risk of GDM was positively associated with maternal central obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics and Quality Assessment Of Includedmentioning

confidence: 99%

Section: Characteristics and Quality Assessment Of Includedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between Maternal Central Obesity and the Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies

Yao

Chang

et al. 2020

Journal of Diabetes Research

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“…[12][13][14][15][16] Nassr showed that body fat index, which is calculated by multiplying the thickness of pre-peritoneal by that of subcutaneous fat and then dividing by the patient's height, is an excellent predictor of the development of GDM. 17 Conventional methods for assessing body composition in pregnancy include anthropometry, density measurement, and hydrometry. Bioelectrical impedance analysis (BIA) is a hydrometric method, and it allows accurate estimates of body composition early in pregnancy (14 weeks), as confirmed by comparison to deuterium dilution.…”

Section: Introductionmentioning

confidence: 99%

<p>The Body Composition in Early Pregnancy is Associated with the Risk of Development of Gestational Diabetes Mellitus Late During the Second Trimester</p>

Liu

Liu²,

Gao

et al. 2020

DMSO

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Objective: Gestational diabetes mellitus (GDM) causes both short-and long-term harm to mothers and fetuses. It is important to predict the occurrence of GDM as early as possible and take adequate measures to prevent it. The purpose of this study was to investigate the association between body composition of pregnant women in early pregnancy and the risk of GDM. Subjects and Methods: A total of 1318 pregnant women in the early stage of pregnancy were recruited from the Guiyang Maternal and Child Health Care Hospital. Detailed clinical data were recorded. Body composition was determined using the bioimpedance method at 13 weeks of gestation. The association between BMI before pregnancy (pre-BMI), fat mass percentage (FMP) and skeletal muscle mass percentage (SMMP) and the results of glucose tolerance screening in the second trimester of pregnancy were analyzed. Fat mass index (FMI) was calculated using fat mass in kilograms as measured using BIA at 13 weeks of pregnancy divided by the square of the woman's height in meters (kg/m 2) and was analyzed to determine the predictive effect of body fat on GDM. Results: Of the 1318 participants, 249 were diagnosed with GDM and 1069 with normal blood glucose. The FMI and FMP in GDM were higher than in NGT (P<0.001), while the SMMP in GDM was lower than in NGT (P<0.001). Overweight women (pre-BMI≥24kg/m 2) had a higher risk of developing GDM than women with normal pre-BMI (adjusted OR 2.604, 95% CI 1.846-3.673). Women with FMP greater than 28% had a higher risk of developing to GDM than women with normal-range FMP (adjusted OR 1.572, 95% CI 1.104-2.240). When FMI is used to predict the incidence of GDM, the area under the curve (AUC) is 65.8%, which is comparable to BMI (AUC=67.2%). Conclusion: Body composition early during gestation is associated with the risk of GDM. The fat mass index in early pregnancy is a predictor of GDM, and it could be an indicator of the efficacy of any intervention to reduce the risk of GDM.

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Gestational diabetes mellitus early prediction by maternal body fat index: A cohort study

da Silva Rocha,

Bernardi,

de Oliveira Neves

et al. 2024

Endocrinología, Diabetes y Nutrición (English ed.)

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Body fat index: A novel alternative to body mass index for prediction of gestational diabetes and hypertensive disorders in pregnancy

Cited by 20 publications

References 16 publications

Relationship between Maternal Central Obesity and the Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies

Relationship between Maternal Central Obesity and the Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies

<p>The Body Composition in Early Pregnancy is Associated with the Risk of Development of Gestational Diabetes Mellitus Late During the Second Trimester</p>

Gestational diabetes mellitus early prediction by maternal body fat index: A cohort study

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