Body Fat Distribution in Women With Polycystic Ovary Syndrome

Douchi, Tsutomu; Ijuin, Hirofumi; Nakamura, Sachiko; Oki, Toshimichi; Yamamoto, Shinako; Nagata, Yukihiro

doi:10.1016/0029-7844(95)00250-u

Cited by 75 publications

(42 citation statements)

References 21 publications

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“…The positive correlation found in the present study between testosterone and total body fat mass in non-obese subjects parallels the well-recognized relationship between excess androgens and adiposity in the PCOS-phenotype [15–17]. In PCOS, whether the rise in androgens precedes increased adiposity and insulin resistance or whether hyperinsulinemia triggers the increase in androgen production remains controversial.…”

Section: Discussionsupporting

confidence: 87%

Relationship of androgens to body composition, energy and substrate metabolism and aerobic capacity in healthy, young women

2011

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Objective To evaluate the role of physiologic levels of androgens and their precursors in the regulation of body composition, energy and substrate metabolism and aerobic capacity in healthy, cycling, premenopausal women. Experimental We evaluated 30 young (27 ± 1 yr) premenopausal, non-obese (23 ± 0.5 kg/m2), normally-cycling women, without clinical or chemical evidence of hyperandrogenism or hyperinsulinemia, for parameters of total and regional body composition, glucose tolerance, aerobic capacity and resting energy expenditure and substrate oxidation. Serum was assayed for androgens and androgen precursors by techniques optimized to assess the low androgen levels in this population. Results Higher serum testosterone levels correlated with greater fat mass (r= .377; p=0.04), but not abdominal adiposity or other metabolic/physiologic variables. Additionally, dehydroepiandrosterone (DHEA) was negatively related to visceral fat content (r=−.569; p=0.02). Other serum androgens did not correlate with total or regional adiposity, skeletal muscle mass, aerobic capacity, glucose tolerance, or resting energy and substrate metabolism. Conclusion In this group of non-obese, premenopausal women with no clinical or chemical evidence of hyperandrogenemia, serum testosterone levels were positively related with fat mass, but not with abdominal adiposity; whereas, DHEA was negatively related to visceral adiposity. Our data suggest that within the normal physiologic range, testosterone is a predictor of overall adiposity, but that this effect does not appear to be associated with concomitant alterations in resting energy or substrate metabolism that could predispose to weight gain.

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Section: Discussionsupporting

confidence: 87%

Relationship of androgens to body composition, energy and substrate metabolism and aerobic capacity in healthy, young women

2011

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“…It is well recognised that visceral distribution of body fat, common in the syndrome, is of greater consequence to the metabolic effects of insulin resistance than obesity per se 1213. Central obesity and insulin resistance lead to an altered lipolytic response to insulin, with impaired suppression of release of free fatty acids from adipose tissue.…”

Section: Metabolism and Health Implicationsmentioning

confidence: 99%

Fortnightly Review: Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology

Hopkinson

Sattar

Fleming

et al. 1998

BMJ

116

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“…Obesity contributes to the prevalence of the metabolic syndrome in PCOS patients [21]. Central obesity is often associated with PCOS [22] and carries increased risk for developing cardiovascular disease and type 2 diabetes [23]. The specific indicators of abdominal obesity are better for discriminating the high coronary risk than the usual obesity indicator BMI (body mass index) [24].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Risk Factors in Bulgarian Patients with Polycystic Ovary Syndrome and/or Obesity

Gateva

Kamenov

2012

Obstetrics and Gynecology International

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Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disturbances in women of reproductive age. Besides its well-known effects on reproductive health, it is also linked to increased cardiovascular risk in later life. The aim of this study is to investigate some classical cardiovascular risk factors in a crossectional study of Bulgarian women with PCOS and/or obesity. We performed a retrospective medical chart review of 375 women from an university endocrine clinic. We found significant differences in the indices of carbohydrate metabolism, blood pressure, lipid profile, rate of liver steatosis, and the levels liver enzymes and hematological results between the lean and obese PCOS women. Obese women without PCOS did not show significantly different results in their OGGT form obese PCOS women. Waist-to-stature-ratio (WSR) correlated better with the baseline IRI levels and lipid profile than waist-to-hip-ratio (WHR) that makes it a better marker for unfavorable metabolic profile.

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Body Fat Distribution in Women With Polycystic Ovary Syndrome

Abstract: Serum DHEA-S levels seem to be associated with upper-half body fat distribution in women with PCOS, irrespective of body weight.

Cited by 75 publications

References 21 publications

Relationship of androgens to body composition, energy and substrate metabolism and aerobic capacity in healthy, young women

Relationship of androgens to body composition, energy and substrate metabolism and aerobic capacity in healthy, young women

Fortnightly Review: Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology

Cardiovascular Risk Factors in Bulgarian Patients with Polycystic Ovary Syndrome and/or Obesity

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