Body fat composition in hidradenitis suppurativa: a hospital‐based cross‐sectional study

Romaní, Jorge; Agut-Busquet, Eugènia; Corbacho, M.; Herrerías-Moreno, José; Luelmo, Jesús

doi:10.1111/ijd.13450

Cited by 7 publications

(8 citation statements)

References 4 publications

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“…Finally, obesity increases the levels of pro-inflammatory cytokines such as IL-1, IL-6, IL-8, TNFa and C-reactive protein. 17,18 All these conditions together clearly explain the presence of the PD signal.…”

Section: Discussionmentioning

confidence: 77%

“…Obesity might influence HS pathogenesis in several ways, due to wider skin folds, enhanced friction, local sweat retention or increased perspiration. Finally, obesity increases the levels of pro‐inflammatory cytokines such as IL‐1, IL‐6, IL‐8, TNFα and C‐reactive protein . All these conditions together clearly explain the presence of the PD signal.…”

Section: Discussionmentioning

confidence: 87%

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Power Doppler ultrasound assessment of vascularization in hidradenitis suppurativa lesions

Caposiena

Solivetti

Bianchi

2018

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 87%

Power Doppler ultrasound assessment of vascularization in hidradenitis suppurativa lesions

Caposiena

Solivetti

Bianchi

2018

Acad Dermatol Venereol

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“…HS develops through interplay of genetic, immunological, endocrine and environmental risk factors, including obesity [12], body composition [24,25], and diet [27]. In particular, both Romaní et al and Miller et al reported that subjects with HS and healthy controls showed differences in FM analyzed by BIA, irrespective of their BMI, with higher FM in HS patients than in healthy controls [24,25]. In this context, higher FM may indicate an altered status of inflammatory homeostasis in adipose tissue that can amplify the morbidity in HS patients.…”

Section: Discussionmentioning

confidence: 99%

“…The association between WC and HS has been reported by several studies [21,22], underlying the role of the pro-inflammatory cytokines produced by visceral fat in the progression and the pathogenesis of HS [23]. Beyond body weight, subjects with HS showed higher body fat than in healthy controls, independent of their BMI [24,25]. Bioelectrical impedance analysis (BIA) is a non-invasive, and reliable tool to estimate body composition that is particularly suitable for studies on large population samples.…”

Section: Introductionmentioning

confidence: 95%

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Role of Nutrition and Adherence to the Mediterranean Diet in the Multidisciplinary Approach of Hidradenitis Suppurativa: Evaluation of Nutritional Status and Its Association with Severity of Disease

et al. 2018

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Hidradenitis suppurativa (HS) is a chronic, inflammatory and debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. We aimed to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naive-treatment patients with HS. In this case–controlled, cross-sectional study, we enrolled 41 HS patients and 41 control subjects. Body composition was evaluated by a bioelectrical impedance analysis (BIA) phase-sensitive system. PREvención con DIeta MEDiterránea (PREDIMED) and the 7-day food records were used to evaluate the degree of adherence to the MD and dietary pattern, respectively. The clinical severity was assessed by using the Sartorius HS score. HS patients had a worse body composition, in particular lower phase angle (PhA) (p < 0.001), and a lower adherence to the MD than controls, in spite of no differences in energy intake between the two groups. The receiver operator characteristic (ROC) analysis showing a value of PhA of ≤ 5.7 and a PREDIMED score of ≤ 5.0 identified HS patients with the highest clinical severity of the disease. After adjusting for sex, age, body mass index (BMI), and total energy intake, the HS Sartorius score maintained negative correlations with PhA (p < 0.001), PREDIMED score, and n-3 polyunsaturated fatty acids (p = 0.005). The results of the multivariate analysis showed PhA and PREDIMED score were the major determinants of HS Sartorius score, explaining 82.0% and 30.4% of its variability, respectively (p < 0.001). Novel associations were demonstrated between PhA and the degree of adherence to the MD with the HS severity. PhA and PREDIMED score might represent possible markers of severity of HS in a clinical setting.

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Unmet clinical needs, burden of disease and treatment patterns in hidradenitis suppurativa: Real‐world experience from Spain

Vilarrasa

Molina-Leyva

Martín

et al. 2023

JEADV Clinical Practice

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BackgroundHidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating skin disease. HS is difficult‐to‐treat, and a multifaceted treatment approach is recommended to achieve adequate clinical response. A greater understanding of HS treatment could help identify unmet clinical needs.ObjectivesTo evaluate disease characteristics and treatment patterns in a real‐world population of patients with HS in Spain.MethodsThis retrospective analysis utilised data collected from the Adelphi HS Disease Specific Programme between November 2020 and April 2021. Dermatologists completed patient record forms (PRFs) for consulting HS patients. Outcomes included disease severity, HS clinical signs, quality of life measures, medical treatments and previous surgeries.ResultsOverall, 53 dermatologists completed 332 PRFs, each representing one patient with HS. Based on physician‐judged disease severity at sampling, 73.8%, 22.9% and 3.3% of patients were classified as mild, moderate or severe, respectively. Overall, patients presented with 2.8±2.7 (mean±SD) HS symptoms, which increased with worsening disease severity. The most frequently reported symptoms were ‘inflammation/redness of HS lesions/abscess’ (45.9%), general pain/discomfort (39.9%) and pain on sitting (32.3%). Overall, patients reported a mean±SD Dermatology Life Quality Index score of 4.7±4.8, which increased with worsening disease severity (mild, 3.9±4.3; moderate, 8.7±5.1; moderate to severe, 9.0±5.1). When asked what effect HS had on everyday activities, a large proportion of patients reported that HS sometimes or greatly affected personal appearance/self‐confidence (66.0%), mood (60.2%), close personal relationships (60.4%), motivation (38.3%), leisure activities (43.0%) and feelings about the future (33.6%). At the time of HS diagnosis, the most frequently prescribed treatment regimens were topicals (70.7%), antibiotics (57.6%) and antiseptics (32.2%). At the time of sampling, the most common treatment regimens were biologics (43.8%), topicals (34.9%) and antibiotics (32.2%). The mean±SD number of surgical interventions was 0.6±0.8; incision and drainage (31.3%), local or limited excision (13.0%), and wide surgical excision of all hair‐bearing skin (9.9%) were the most common surgeries.ConclusionsThese real‐world data suggest a high disease burden in patients with HS in Spain. Patients received multiple treatments, and a notable proportion underwent surgery. More data are needed to define optimal HS management strategies.This article is protected by copyright. All rights reserved.

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Body fat composition in hidradenitis suppurativa: a hospital‐based cross‐sectional study

Cited by 7 publications

References 4 publications

Power Doppler ultrasound assessment of vascularization in hidradenitis suppurativa lesions

Power Doppler ultrasound assessment of vascularization in hidradenitis suppurativa lesions

Role of Nutrition and Adherence to the Mediterranean Diet in the Multidisciplinary Approach of Hidradenitis Suppurativa: Evaluation of Nutritional Status and Its Association with Severity of Disease

Unmet clinical needs, burden of disease and treatment patterns in hidradenitis suppurativa: Real‐world experience from Spain

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