Body fat and the cognitive pattern: A population-based study

Tikhonoff, Valérie; Casíglia, Edoardo; Guidotti, Federica; Giordano, Nunzia; Martini, Bortolo; Mazza, Alberto; Spinella, Paolo; Palatini, Paolo

doi:10.1002/oby.21114

Cited by 23 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When BP was taken in the office, the values measured at the wrist were, as shown by others, [18][19][20][21][22][23][24][25] slightly lower than those measured at the upper-arm. In contrast, when BP was self-measured at home by the study participants, higher BP values were obtained at the wrist than at the arm.…”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Poor Reliability of Wrist Blood Pressure Self-Measurement at Home

et al. 2016

Self Cite

View full text Add to dashboard Cite

Blood pressure (BP) independently predicts cardiovascular risk in affluent countries. [1][2][3][4][5] However, several studies have shown that awareness of hypertension and BP control is still suboptimal, 1 and thus effective strategies should be developed to improve BP control and adherence to therapy. One of the methods used to achieve these goals is represented by self-measurement of BP at home by automatic devices. Many studies have shown that BP self-measurement at home allows a better BP control in hypertension and has a greater prognostic value than office BP. 6,7 In addition, self BP measurement is more appealing to the patient than the customary procedure in the physician's surgery often causing long waits. Upper-arm automatic devices gave fresh impetus to home self-measurement because of their user friendliness, 8 the only conditions to be respected being adequate cuff dimensions and correct positioning of the cuff on the patient's arm. [9][10][11][12][13][14] For reasons of market penetration and following a general tendency to miniaturization, many wrist devices recently appeared on the market 15 having the advantage of being smaller and easier to fit than upper-arm monitors, 16 and today wrist devices are used by a large portion of people who measure their BP at home. 17 However, in spite of technical improvement, their reliability in real-life conditions is not unanimously accepted. [18][19][20] Accuracy of BP measurement at wrist largely depends on the difference in height between the wrist and the heart because of the confounding effect of the hydrostatic pressure caused by the limb blood column.21-23 Wrists kept at a higher level in comparison with the heart lead to a false lower, and wrists at a lower level lead to a false higher BP values. Very rarely do patients receive appropriate training from family doctors or other healthcare personnel. Instructions attached to commercial packages require a certain degree of personal discernment, i.e., a good cognitive pattern. Only a few models have a position sensor to verify that the wrist is placed properly at heart level, 24 but even for these devices, no study has evaluated their reliability in real-life conditions.The aim of the present study was to ascertain whether wrist home BP is performed reliably or an error is present in measurement, and to identify the determinants of this error if any.To verify the reliability of wrist BP self-measurement, we determined at a population level the upper-arm−wrist BP difference in the office under a doctor's supervision and then verified whether this difference was maintained during home self-measurement.Abstract-The reliability of blood pressure measurement with wrist devices, which has not previously been assessed under real-life circumstances in general population, is dependent on correct positioning of the wrist device at heart level. We determined whether an error was present when blood pressure was self-measured at the wrist in 721 unselected subjects from the general population. After training, blood p...

show abstract

Section: Discussionmentioning

confidence: 84%

“…25 At screening, all underwent anthropometrics and a questionnaire. 26 Education was defined as years of schooling based on the highest educational qualification achieved.…”

Section: Study Population and General Protocolmentioning

confidence: 99%

Poor Reliability of Wrist Blood Pressure Self-Measurement at Home

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Interestingly, this result is similar to a recent study which reveals that fat mass index is reduced in PD patients, and reduced fat is associated with higher risk of motor complications in PD [17], corresponding with the higher UPDRS III score of the PDSa patients in this study. Although the pathophysiology of this finding is unclear, higher BMI, fat mass, and lean body mass in elders have a positive association with better cognitive performance, especially in executive function [18,19]. In contrast, enhanced fat loss resulting from sarcopenia is associated with decreased cognitive function…”

Section: Discussionmentioning

confidence: 99%

Correlation between Executive Network Integrity and Sarcopenia in Patients with Parkinson’s Disease

Lee

Chen

et al. 2019

IJERPH

View full text Add to dashboard Cite

Background: Sarcopenia is critically associated with morbidity and mortality in the progression of Parkinson's disease (PD). However, analyses of clinical severity and brain changes, such as white matter (WM) alterations in PD patients with sarcopenia are limited. Further understanding of the factors associated with sarcopenia may provide a focused screen and potential for early intervention in PD patients. Methods: 52 PD patients and 19 healthy participants accepted dual-energy X-ray absorptiometry to measure the body composition. Using diffusion tensor imaging, the difference of WM integrity was measured between PD patients with sarcopenia (PDSa) and without sarcopenia (PDNSa). Multivariate analysis was performed to explore the relationships between clinical factors, WM integrity, and sarcopenia in PD patients. Results: 21 PD patients (40.4%) had sarcopenia. PDSa had a higher Unified Parkinson's Disease Rating Scale (UPDRS III) score, lower body mass index (BMI) and lower fat weight compared with the PDNSa. Additionally, PDSa patients exhibited lower fractional anisotropy accompanied by higher radial diffusivity and/or higher mean diffusivity in the fronto-striato-thalamic circuits, including bilateral cingulum, left superior longitudinal fasciculus, left genu of corpus callosum, and right anterior thalamic radiation, which participate in the executive function. In addition, decreased muscle mass was associated with worse WM integrity in these regions. Multiple linear regression analysis revealed that WM integrity in the left cingulum, right anterior thalamic radiation, together with gender (male) significantly predicted muscle mass in PD patients. Conclusions: WM alterations in the executive network, such as the fronto-striato-thalamic circuits, may indicate a risk factor for ongoing sarcopenia in PD patients. The effectiveness of using executive function to serve as a prodromal marker of sarcopenia in PD patients should be evaluated in future studies.

show abstract

“…Cardiovascular disease may be especially relevant as bilateral oophorectomy has been reported to increase the risk of cardiovascular disease (16). In addition, local estrogen biosynthesis in adipose tissue is a primary source for estrogen in postmenopausal women, and body mass index (BMI) has been associated with cognitive function in late life (17–20). …”

mentioning

confidence: 99%

Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal women

Kurita

Henderson

Gatz

et al. 2016

Fertility and Sterility

View full text Add to dashboard Cite

Objective To investigate the association between bilateral oophorectomy and cognitive performance in healthy, older women. Design Retrospective analysis of clinical trial data. Setting Academic research institution. Patient(s) Healthy postmenopausal women without signs or symptoms of cardiovascular disease or diabetes (n = 926). Intervention(s) Randomized interventions (not the focus of this analysis) in analyzed trials included B-vitamins, soy isoflavones, oral estradiol, and matching placebos. Main Outcome Measure(s) Measures in five cognitive domains (executive functions, semantic memory, logical memory, visual memory, and verbal learning) and global cognitive function. Result(s) Using data from three clinical trials conducted under uniform conditions, bilateral oophorectomy and its timing were analyzed cross-sectionally and longitudinally in relation to cognitive function in linear regression models. Covariates included age, education, race/ethnicity, body mass index, trial, and randomized treatment (in longitudinal models). Duration of menopausal hormone use was considered as a possible mediator and effect modifier. Median age of oophorectomy was 45 years. When evaluating baseline cognition, we found that surgical menopause after 45 years of age was associated with lower performance in verbal learning compared with natural menopause. Evaluating the change in cognition over approximately 2.7 years, surgical menopause was associated with performance declines in visual memory for those who had an oophorectomy after 45 years of age and in semantic memory for those who had oophorectomy before 45 years of age compared with natural menopause. Oophorectomy after natural menopause was not associated with cognitive performance. Adjustment for duration of hormone use did not alter these associations. Conclusion(s) Cognitive associations with ovarian removal vary by timing of surgery relative to both menopause and age.

show abstract

Body fat and the cognitive pattern: A population-based study

Cited by 23 publications

References 38 publications

Poor Reliability of Wrist Blood Pressure Self-Measurement at Home

Poor Reliability of Wrist Blood Pressure Self-Measurement at Home

Correlation between Executive Network Integrity and Sarcopenia in Patients with Parkinson’s Disease

Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal women

Contact Info

Product

Resources

About