Body dysmorphic disorder due to hirsutism in a patient treated with cyclosporin

Vergoulas, G; Eleftheriadis, Theodoros; Avdelidou, Aphroditi; Ιωάννου, Κωνσταντίνος; Miserlis, Gregorios; Solonaki, F.; Papagiannis, A.; Takoudas, D

doi:10.1093/ndt/gfh635

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Weight gain after kidney transplantation is common and can result in obesity in patients with a previously normal body mass index ( 69 ). Immunosuppressive medication prescribed after transplantation can also alter physical appearance, particularly where hirsutism develops with ciclosporin treatment ( 70 ).…”

Section: Body Image and Ckdmentioning

confidence: 99%

Male Sexual Dysfunction and Chronic Kidney Disease

Edey

2017

Front. Med.

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Male sexual dysfunction is common in chronic kidney disease (CKD), particularly in end-stage renal disease. Historically, this cause of considerable morbidity has been under-reported and under-recognized. The ideal approach to diagnosis and management remains unclear due to a paucity of good quality data, but an understanding of the pathophysiology is necessary in order to address the burden of this important complication of CKD. This paper will review the endocrine dysfunction that occurs in renal disease, particularly the hypothalamic–pituitary–gonadal axis, discuss the causes of erectile dysfunction, infertility, and altered body image and libido in these patients and suggest appropriate treatment interventions.

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Section: Body Image and Ckdmentioning

confidence: 99%

Male Sexual Dysfunction and Chronic Kidney Disease

Edey

2017

Front. Med.

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“…In our study, it was thought that men had better sexual functions after transplantation for similar reasons. In addition, weight gain after kidney transplantation (28) and hair growth as a side effect of drugs may be increased (29). Body perception, is critical in sexual function; therefore, the possibility of obesity and hair growth increase in women after transplantation, could have negatively influenced their sex life.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Knowledge, Perception About Transplantation and Life Changes in Renal Transplant Patients

Bozkurt¹

2020

BMB

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The objective of the study was to determine subjective factors such as adherence to treatment, knowledge levels, individual perceptions and lifestyle changes with a view to determine variables that could be useful for future processes in patients undergoing kidney transplant. Method: The study was conducted in the Nephrology Department of Gaziosmanpaşa Hospital, between January 2019 and November 2019. Fifty people aged between 18-70 years who had undergone renal transplantation at least 3 months ago and were treated as outpatients by applying to the nephrology clinic were evaluated. A semi-structured questionnaire including questions about their knowledge regarding transplantation, lifestyle changes in the transplantation process and personal perceptions was administered to the patients. Results: All patients expressed satisfaction with every step of the transplantation process. 32% of the patients were uncomfortable with medication and hospital visits and 44% were happy that dialysis was not in their life. 86% of the patients who underwent kidney transplantation reported increased quality of life after the operation and 36.7% stated that their sexual life changed positively. It was found that those who adhered to treatment mostly interrupted the use of medication (24%), and the sexual life of men and also patients with children were significantly affected more positively by transplantation. Those who did not receive adequate information before treatment had significantly more problems with adherence to treatment. Conclusion: It was found that the quality of life of the patients improved significantly after kidney transplantation. Men's sexuality was affected more positively by transplantation. By endeavoring to improve patients' knowledge and perceptions prior to kidney transplantation, patient satisfaction and adherence to treatment can be significantly improved.

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The Dosage Recommendation of Cyclosporin in Children with Hemophagocytic Lymphohistiocytosis based on Population Pharmacokinetic Model

Yang,

Li,

et al. 2023

CPD

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Objectives:: Cyclosporin is one of the therapeutic regimens for hemophagocytic lymphohistiocytosis (HLH); however, the optimal dosage of cyclosporine in children with HLH is unknown. It has been found that piperacillin-tazobactam affects the cyclosporine pharmacokinetic process in pediatric HLH patients. Thus, the purpose of the present study was to recommend cyclosporin dosage for pediatric HLH with and without piperacillin- tazobactam. Methods:: A previously established cyclosporine population pharmacokinetic model for pediatric HLH patients has been used in this study to recommend optimal dosage based on Monte Carlo simulation. The pediatric HLH patients have been included in eight weight groups (5, 10, 20, 30, 40, 50, 60, 70 kg) for sixteen dosages (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 mg/kg), split into one dose or two doses. Results:: The optimal cyclosporin dosages for children having HLH without piperacillin-tazobactam have been found to be 15, 13, 12, 11, 10, and 9 mg/kg, split into two doses for weights of 5-7, 7-10, 10-20, 20-28, 28-45, and 45-70 kg, respectively. For children with HLH, optimal cyclosporin dosages with piperacillin-tazobactam have been found to be 8 and 7 mg/kg, split into two doses for weights of 5-20 and 20-70 kg, respectively. Conclusion: It is the first time that the cyclosporin dosage regimens for HLH in children have been developed based on Monte Carlo simulation, and the initial dosage optimizations of cyclosporine in pediatric HLH patients have been recommended.

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Body dysmorphic disorder due to hirsutism in a patient treated with cyclosporin

Cited by 4 publications

References 3 publications

Male Sexual Dysfunction and Chronic Kidney Disease

Male Sexual Dysfunction and Chronic Kidney Disease

Assessment of Knowledge, Perception About Transplantation and Life Changes in Renal Transplant Patients

The Dosage Recommendation of Cyclosporin in Children with Hemophagocytic Lymphohistiocytosis based on Population Pharmacokinetic Model

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