Body Cooling Ameliorating Spinal Cord Injury May Be Neurogenesis-, Anti-inflammation- and Angiogenesis-Associated in Rats

Kao, Cheng-Hsing; Chio, Chung-Ching; Lin, Mao‐Tsun; Yeh, Chao‐Hung

doi:10.1097/ta.0b013e3181e7456d

Cited by 18 publications

(19 citation statements)

References 41 publications

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“…Body cooling (33 °C) also improves SCI outcomes by promoting angiogenesis, neurogenesis, and anti-inflammation in a rat SCI model [31]. Hyperbaric oxygen therapy improved the outcomes of SCI by stimulating spinal cord production of both vasculoendothelial and glial cell line-derived neurotrophic growth factor and interleukin (IL)-10 (an anti-inflammatory cytokine) in rats [32].…”

Section: Discussionmentioning

confidence: 99%

Exercise Preconditioning Protects against Spinal Cord Injury in Rats by Upregulating Neuronal and Astroglial Heat Shock Protein 72

Chang

Chou

Lin

et al. 2014

IJMS

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The heat shock protein 72 (HSP 72) is a universal marker of stress protein whose expression can be induced by physical exercise. Here we report that, in a localized model of spinal cord injury (SCI), exercised rats (given pre-SCI exercise) had significantly higher levels of neuronal and astroglial HSP 72, a lower functional deficit, fewer spinal cord contusions, and fewer apoptotic cells than did non-exercised rats. pSUPER plasmid expressing HSP 72 small interfering RNA (SiRNA-HSP 72) was injected into the injured spinal cords. In addition to reducing neuronal and astroglial HSP 72, the (SiRNA-HSP 72) significantly attenuated the beneficial effects of exercise preconditioning in reducing functional deficits as well as spinal cord contusion and apoptosis. Because exercise preconditioning induces increased neuronal and astroglial levels of HSP 72 in the gray matter of normal spinal cord tissue, exercise preconditioning promoted functional recovery in rats after SCI by upregulating neuronal and astroglial HSP 72 in the gray matter of the injured spinal cord. We reveal an important function of neuronal and astroglial HSP 72 in protecting neuronal and astroglial apoptosis in the injured spinal cord. We conclude that HSP 72-mediated exercise preconditioning is a promising strategy for facilitating functional recovery from SCI.

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Section: Discussionmentioning

confidence: 99%

Exercise Preconditioning Protects against Spinal Cord Injury in Rats by Upregulating Neuronal and Astroglial Heat Shock Protein 72

Chang

Chou

Lin

et al. 2014

IJMS

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“…However, other evidence indicates that hypothermia suppresses the expression of VEGF (and HIF-1α) by T98G cells (derived from human glioblastoma multiform) independently of changes in O 2 consumption (Tanaka et al, 2010). Evidence also exists that hypothermia increases angiogenesis in the spinal cord (Kao et al, 2011) and brain (Kuo et al, 2010). More research is therefore needed to understand the effects of icing on ROS production and angiogenesis in skeletal muscle following injury.…”

Section: Discussionmentioning

confidence: 99%

“…Second, angiogenesis is closely linked with muscle repair. Evidence from other tissue types suggests that hypothermia can alter the secretion of vascular endothelial growth factor (VEGF) (Coassin et al, 2010; Takeyama et al, 2015) and angiogenesis (Kuo et al, 2010; Kao et al, 2011). It remains unknown whether hypothermia exerts similar effects in skeletal muscle tissue.…”

Section: Introductionmentioning

confidence: 99%

Effects of Topical Icing on Inflammation, Angiogenesis, Revascularization, and Myofiber Regeneration in Skeletal Muscle Following Contusion Injury

et al. 2017

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Contusion injuries in skeletal muscle commonly occur in contact sport and vehicular and industrial workplace accidents. Icing has traditionally been used to treat such injuries under the premise that it alleviates pain, reduces tissue metabolism, and modifies vascular responses to decrease swelling. Previous research has examined the effects of icing on inflammation and microcirculatory dynamics following muscle injury. However, whether icing influences angiogenesis, collateral vessel growth, or myofiber regeneration remains unknown. We compared the effects of icing vs. a sham treatment on the presence of neutrophils and macrophages; expression of CD34, von Willebrands factor (vWF), vascular endothelial growth factor (VEGF), and nestin; vessel volume; capillary density; and myofiber regeneration in skeletal after muscle contusion injury in rats. Muscle tissue was collected 1, 3, 7, and 28 d after injury. Compared with uninjured rats, muscles in rats that sustained the contusion injury exhibited major necrosis, inflammation, and increased expression of CD34, vWF, VEGF, and nestin. Compared with the sham treatment, icing attenuated and/or delayed neutrophil and macrophage infiltration; the expression of vWF, VEGF, and nestin; and the change in vessel volume within muscle in the first 7 d after injury (P < 0.05). By contrast, icing did not influence capillary density in muscle 28 d after injury (P = 0.59). The percentage of immature myofibers relative to the total number of fibers was greater in the icing group than in the sham group 28 d after injury (P = 0.026), but myofiber cross-sectional area did not differ between groups after 7 d (P = 0.35) and 28 d (P = 0.30). In conclusion, although icing disrupted inflammation and some aspects of angiogenesis/revascularization, these effects did not result in substantial differences in capillary density or muscle growth.

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“…In the developing brain, a temperature of 30 8C decreased the number of proliferating cells in the SGZ [55], whereas in other hypoxic conditions, hypothermia (33 8C) enhanced maturation of neuronal progenitor cells in the striatum [56]. Neuronal connectivity, angiogenesis and gliogenesis are stimulated by hypothermic conditions [57][58][59][60][61]. Although the effect of hypothermia in brain regeneration is far from clear, it seems to have beneficial effects and more research is needed in this area to reach any kind of conclusion.…”

Section: Icu Therapies and Neurogenesismentioning

confidence: 98%

Adult neurogenesis and brain remodelling after brain injury: From bench to bedside?

Quintard

Heurteaux

Ichaï

2015

Anaesthesia Critical Care & Pain Medicine

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Body Cooling Ameliorating Spinal Cord Injury May Be Neurogenesis-, Anti-inflammation- and Angiogenesis-Associated in Rats

Abstract: BC (33°C) improved SCI outcomes by promoting angiogenesis, neurogenesis, and anti-inflammation in a rat SCI model.

Cited by 18 publications

References 41 publications

Exercise Preconditioning Protects against Spinal Cord Injury in Rats by Upregulating Neuronal and Astroglial Heat Shock Protein 72

Exercise Preconditioning Protects against Spinal Cord Injury in Rats by Upregulating Neuronal and Astroglial Heat Shock Protein 72

Effects of Topical Icing on Inflammation, Angiogenesis, Revascularization, and Myofiber Regeneration in Skeletal Muscle Following Contusion Injury

Adult neurogenesis and brain remodelling after brain injury: From bench to bedside?

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