Body compositions differently contribute to BMD in different age and gender: a pilot study by QCT

Zhang, Xueli; Ting, Hua; Zhu, Jinxia; Peng, Kun; Yang, Jun; Kang, Sifeng; Xu, Tianmin; Hu, Jian; Tang, Guangyu

doi:10.1007/s11657-019-0574-5

Cited by 18 publications

(26 citation statements)

References 26 publications

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“…It has been shown that BMD often decreases substantially after the age of 50, and BMD has been associated with variations in sex hormones. 21 , 22 It is known that sex hormone levels or functional hormone receptors will decrease with age, which plays a significant role in the osteoporosis process. 11 Estrogens exert their regulatory potential on exhibiting the upregulating effect through subunit estrogen receptor (ER).…”

Section: Discussionmentioning

confidence: 99%

Associations of Sex Hormone-binding Globulin with Bone Mineral Density Among US Adults, NHANES 2013–2016

Yang

Zhou

et al. 2021

IJGM

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Section: Discussionmentioning

confidence: 99%

Associations of Sex Hormone-binding Globulin with Bone Mineral Density Among US Adults, NHANES 2013–2016

Yang

Zhou

et al. 2021

IJGM

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“…Thus, establishing a practical alternative method to estimate abdominal fat content is urgently needed. The usefulness of QCT software for volumetric bone mineral density (BMD) analysis has been widely recognized, and the supplement tool of abdominal fat quantitative analysis achieved favorable results in opportunistic scanning uses without additional radiation exposure ( 16 , 20 ). It is feasible to investigate the abdominal VAT in a QCT scan.…”

Section: Introductionmentioning

confidence: 99%

The Optimal Axial Anatomical Site for a Single-Slice Area to Quantify the Total Volume of Visceral Adipose Tissue in Quantitative CT

Chen

et al. 2022

Front. Endocrinol.

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PurposeDetermine the association between cross-sectional visceral adipose tissue (VAT) area of different anatomic locations and total abdominopelvic VAT volume; identify the optimal measurement site in a single-slice to quantify the total VAT volume.MethodParticipants who underwent non-contrast abdominal scan by quantitative CT (QCT) were enrolled from May 2021 to October 2021. The VAT area (cm2) at different anatomic sites as upper-pole, lower-pole, and hilum of the kidney, intervertebral disc of L2/L3 and L5/S1, and umbilical level were measured on QCT PRO BMD workstation (Mindways QCT PRO workstation). The total VAT volume (cm3) from the upper pole of kidney to the L5/S1 intervertebral disc of the pelvis (abdominopelvic region) was obtained by using Siemens Healthineers Syngo via Frontier cardiac risk assessment. Regression models were used to identify the optimal single-slice in different gender for estimating VAT volume. Statistical significance was established at P < 0.05.ResultsTotal of 311 Chinese participants including 179 men [age, 55.1 ± 14.9 years; body mass index (BMI), 24.2 ± 3.2 kg/m2; total VAT volume, 2482.6 ± 1276.5 mL] and 132 women [age, 54.3 ± 14.9; BMI, 23.5 ± 2.9; total VAT volume, 1761.5 ± 876.4]. Pearson’s correlation analysis revealed a strong association between the VAT area and total abdominopelvic VAT volume at the hilum of the kidney in both men (r=0.938, P<0.001) and women (r=0.916, P<0.001). Adjust for covariates including age, BMI, and waist circumference make a relatively small effect on predicting the total VAT volume.ConclusionsMeasurement of cross-sectional areas at the hilum of the kidney in both genders showed a strongest relation to TVAT volume. Our results may provide an identifiable and valuable axial landmark for measuring visceral adipose tissue in clinical practice.

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“…Therefore, PTH may be the true intermediate factor causing the correlation between fat metabolism and BMD. However, researchers have also observed that body compositions contribute differently to BMD in different ages and genders (29,30). Further investigation is required on the causal relationship between fat tissue and BMD in PHPT patients.…”

Section: Discussionmentioning

confidence: 99%

Using QCT to evaluate bone mineral and abdominal adipose changes in patients with primary hyperparathyroidism and comparing it to DXA for bone status assessment: a retrospective case-control study

Chen¹,

Pan²,

Zhong³

et al. 2022

Ann Transl Med

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Background: Patients with primary hyperparathyroidism (PHPT) show changes in bone metabolism and adipose tissue, but the results are inconsistent. Quantitative computed tomography (QCT) was reported useful for detecting bone mineral and adipose tissue change, but information on the role of QCT in PHPT is limited. We aimed to explore the changes of lumbar bone mineral density (BMD) and abdominal adipose tissue in patients with PHPT using QCT based on existed CT images, and to assess the consistency between QCT and dual-energy X-ray absorptiometry (DXA) in assessing bone status.Methods: This retrospective case-control study was conducted on 48 PHPT patients, with healthy controls (HCs) matched by their age (±3 years) and gender, and the case-to-control ratio was approximately 1:3.Volumetric bone mineral density (vBMD), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT) were measured by QCT in both PHPT and control groups and compared with the independent samples T-test. In the PHPT group, areal bone mineral density (aBMD) was measured by DXA. Pearson correlation analysis was used to investigate the association between QCT-derived vBMD and DXA-derived aBMD. Weighted kappa consistency analysis was used to clarify the agreement between QCT and DXA.Results: Compared with HCs, the PHPT group had significantly lower vBMD (114.30±41.71 vs. 136.92±42.23 mg/cm 3 ; P=0.002) and higher TAT (261.98±74.65 vs. 236.69±69.00 cm 2 ; P=0.033); however, differences in SAT (120.81±40.19 vs. 109.94±36.83 cm 2 ; P=0.085) and VAT (141.17±48.11 vs. 126.75±50.50 cm 2 ; P=0.085) were not statistically significant. There was a strong correlation between QCT-derived vBMD and

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Body compositions differently contribute to BMD in different age and gender: a pilot study by QCT

Cited by 18 publications

References 26 publications

Associations of Sex Hormone-binding Globulin with Bone Mineral Density Among US Adults, NHANES 2013–2016

Associations of Sex Hormone-binding Globulin with Bone Mineral Density Among US Adults, NHANES 2013–2016

The Optimal Axial Anatomical Site for a Single-Slice Area to Quantify the Total Volume of Visceral Adipose Tissue in Quantitative CT

Using QCT to evaluate bone mineral and abdominal adipose changes in patients with primary hyperparathyroidism and comparing it to DXA for bone status assessment: a retrospective case-control study

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