Body Composition, Serum Biomarkers of Inflammation and Quality of Life in Clinically Stable Women with Estrogen Receptor Positive Metastatic Breast Cancer

Sheean, Patricia M.; Gomez-Perez, Sandra L.; Joyce, Cara; Vasilopoulos, Vasilios; Bartolotta, Mary Beth; Robinson, Patricia A.; Lo, Shelly S.; Lomasney, Laurie M

doi:10.1080/01635581.2019.1595053

Cited by 18 publications

(32 citation statements)

References 46 publications

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“…In both groups, lipid infiltration was below the threshold (< 37.8 HU) raising the need to measure both the sarcopenia indicator and the muscle quality indicator, both of which are correlated with an increased risk of death [ 9 ]. Using a threshold for SMI of ≤ 41cm 2 /m 2 as proposed by Martin et al, another cross-sectional study in 41 metastatic breast cancer patients reported a 34% prevalence of sarcopenia [ 64 , 65 ]. These results reinforce the need to systematically assess body composition and sarcopenia in patients with cancer.…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial

Delrieu

Martin

Touillaud

et al. 2021

Breast Cancer Res Treat

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Purpose Sarcopenia has been identified as an important prognostic factor for patients with cancer. This study aimed at exploring the potential associations between a 6-month physical activity intervention and muscle characteristics, sarcopenia, oxidative stress and toxicities in patients with metastatic breast cancer. Methods Women newly diagnosed with metastatic breast cancer (N = 49) participated in an unsupervised, personalized, 6-month physical activity intervention with activity tracker. Computerized tomography images at the third lumbar vertebra were analysed at baseline, three months and six months to assess sarcopenia (muscle mass index < 40 cm2/m2) and muscle quality (poor if muscle attenuation < 37.8 Hounsfield Units). Oxidative markers included plasma antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase activities), prooxidant enzymes (NADPH oxidase and myeloperoxidase activities) and oxidative stress damage markers (advanced oxidation protein products, malondialdehyde (MDA) and DNA oxidation. Results At baseline 53% (mean age 55 years (SD 10.41)) were sarcopenic and 75% had poor muscle quality. Muscle cross sectional area, skeletal muscle radiodensity, lean body mass remained constant over the six months (p = 0.75, p = 0.07 and p = 0.75 respectively), but differed significantly between sarcopenic and non-sarcopenic patients at baseline and 6-months. Sarcopenic patients at baseline were more likely to have an increase of MDA (p = 0.02) at 6 months. Being sarcopenic during at least one moment during the 6-month study was associated with a higher risk of developing severe toxicities (grade > 2) (p = 0.02). Conclusions This study suggests potential benefits of physical activity for maintenance of muscle mass. Sarcopenia can alter many parameters and disturb the pro and antioxidant balance.

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Section: Discussionmentioning

confidence: 99%

Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial

Delrieu

Martin

Touillaud

et al. 2021

Breast Cancer Res Treat

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“…Recent studies have reported a correlation between sarcopenia and long-term prognosis in metastatic colorectal cancer and metastatic breast cancer. 13,24 Furthermore, Ataseven et al reported on the utility of the skeletal muscle index measured through CT as a prognostic predictor in advanced ovarian cancer. 25 However, no study has shown a correlation between sarcopenia and prognosis in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Our findings suggest that PMI is an independent prognostic factor among patients with organ metastatic cervical cancer. Recent studies have reported a correlation between sarcopenia and long‐term prognosis in metastatic colorectal cancer and metastatic breast cancer 13,24 . Furthermore, Ataseven et al reported on the utility of the skeletal muscle index measured through CT as a prognostic predictor in advanced ovarian cancer 25 .…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer

et al. 2020

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Background: This study was conducted to investigate the prognostic significance of sarcopenia in patients with organ metastatic cervical cancer. Methods: Accordingly, the data of 40 patients with organ metastatic cervical cancer treated at our institute from December 2004 to December 2017 were retrospectively analyzed. The correlation between clinicopathological characteristics and survival was then evaluated using univariate and multivariate analyses. Psoas muscle index (PMI), calculated from the psoas muscle area at the L3 vertebral-body level using computed tomography images obtained for pretreatment evaluation, was adopted as an index of sarcopenia. Results: The median follow-up period was 14 months (range, 1-91 months). Kaplan-Meier analysis showed a 3-and 5-year overall survival (OS) rate of 46.1% and 35.8% for all patients, respectively. Receiver operating characteristic curve maximizing the area under the curve showed that the optimal PMI for predicting 1-year survival was 3.72 cm 2 /m 2. Patients with a PMI > 3.72 cm 2 /m 2 had significantly better OS than those with a PMI ≤ 3.72 cm 2 /m 2 (P = .046). Multivariate analysis revealed that only PMI was significantly associated with OS in patients with organ metastatic cervical cancer. Furthermore, patients with a PMI > 3.72 cm 2 /m 2 who underwent concurrent chemoradiotherapy (CCRT) had a longer OS than those receiving other therapies (P < .001). Conclusions: High PMI was determined to be a favorable prognostic factor for patients with organ metastatic cervical cancer. Moreover, patients with organ metastatic cervical cancer who have a PMI > 3.72 cm 2 /m 2 may benefit from CCRT as an initial treatment.

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“…The results of a retrospective study showed that breast WAT inflammation is usually generated in overweight/obese BC women and may be related to abnormal circulatory indicators related to metabolic syndrome ( 81 ). Previous studies have confirmed the systemically BC promotion effect of adipose inflammation via circulating pro-inflammatory cytokines, such as IL-6 and TNF-α ( 82 ). Since BC is located in a fat-rich environment, recent studies have mainly focused on the local effects of inflamed adipose tissue, including the impact of cytokine levels in mammary adipose tissue on BC ( 83 ).…”

Section: Mechanisms Linking Obesity and Breast Cancermentioning

confidence: 70%

Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer

Zhao

et al. 2021

Front. Oncol.

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Obesity is defined as a chronic disease induced by an imbalance of energy homeostasis. Obesity is a widespread health problem with increasing prevalence worldwide. Breast cancer (BC) has already been the most common cancer and one of the leading causes of cancer death in women worldwide. Nowadays, the impact of the rising prevalence of obesity has been recognized as a nonnegligible issue for BC development, outcome, and management. Adipokines, insulin and insulin-like growth factor, sex hormone and the chronic inflammation state play critical roles in the vicious crosstalk between obesity and BC. Furthermore, obesity can affect the efficacy and side effects of multiple therapies such as surgery, radiotherapy, chemotherapy, endocrine therapy, immunotherapy and weight management of BC. In this review, we focus on the current landscape of the mechanisms of obesity in fueling BC and the impact of obesity on diverse therapeutic interventions. An in-depth exploration of the underlying mechanisms linking obesity and BC will improve the efficiency of the existing treatments and even provide novel treatment strategies for BC treatment.

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Body Composition, Serum Biomarkers of Inflammation and Quality of Life in Clinically Stable Women with Estrogen Receptor Positive Metastatic Breast Cancer

Abstract: Title: Body composition, serum biomarkers of inflammation and quality of life in clinically stable women with estrogen receptor positive (ER+) metastatic breast cancer (BC)

Cited by 18 publications

References 46 publications

Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial

Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial

Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer

Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer

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