Body composition predictors of outcome in patients with COVID-19

Bunnell, Katherine M; Thaweethai, Tanayott; Buckless, Colleen; Shinnick, Daniel J.; Torriani, Martin; Foulkes, Andrea S.; Bredella, Miriam A.

doi:10.1038/s41366-021-00907-1

Cited by 31 publications

(30 citation statements)

References 43 publications

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“…Recent literature data suggest that in addition to the well-established association between BMI-based obesity and severe COVID-19 outcome, the body fat distribution is also important; in particular, visceral adipose tissue and upper abdominal circumference have been proposed as simple tools for risk assessment in COVID-19 patients [ 122 , 123 , 124 , 125 ]. More recently, an interesting prospective multicenter study on hospitalized COVID-19 patients with respiratory failure showed that a larger neck circumference phenotype patient is more prone to have a negative outcome, a large neck being associated with an increased proinflammatory and prothrombotic status.…”

Section: Implications Of the Findings And Future Perspectivesmentioning

confidence: 99%

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Ragnoli

Pochetti

Pignatti

et al. 2022

IJERPH

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Sleep health and its adaptation to individual and environmental factors are crucial to promote physical and mental well-being across animal species. In recent years, increasing evidence has been reported regarding the relationship between sleep and the immune system and how sleep disturbances may perturb the delicate balance with severe repercussions on health outcomes. For instance, experimental sleep deprivation studies in vivo have reported several major detrimental effects on immune health, including induced failure of host defense in rats and increased risk for metabolic syndrome (MetS) and immune suppression in humans. In addition, two novel risk factors for dysregulated metabolic physiology have recently been identified: sleep disruption and circadian misalignment. In light of these recent findings about the interplay between sleep and the immune system, in this review, we focus on the relationship between sleep deprivation and immunity against viruses, with a special interest in SARS-CoV-2 infection.

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Section: Implications Of the Findings And Future Perspectivesmentioning

confidence: 99%

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Ragnoli

Pochetti

Pignatti

et al. 2022

IJERPH

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show abstract

“… 69 Other investigators have attributed worse prognosis in ARDS patients to higher visceral/subcutaneous adipose tissue ratio, rather than just higher VAT. 71 , 72 Furthermore, the cardiometabolic risk can also be predicted by other unhealthy fat distribution indicated by impaired ability to expand subcutaneous fat in the lower part of the body, in the gluteofemoral region and in the legs. 73 Such pattern of lower-body fat mass distribution is equally important to a high amount of visceral fat mass as a determinant of cardiometabolic diseases.…”

Section: Pathogenetic Mechanismsmentioning

confidence: 99%

COVID-19 infection and body weight: A deleterious liaison in a J-curve relationship

Manolis

et al. 2021

Obesity Research & Clinical Practice

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“…to be positively associated with adverse outcomes from COVID [12]. By contrast, one study found that epicardial adipose tissue attenuation is a marker of inflammation, but not obesity, predicted admission to intensive care among COVID patients who underwent CT for pneumonia [13].…”

Section: Covidmentioning

confidence: 95%

Body weight, vitamin D and zinc: A review of associations with coronavirus disease (COVID-19)

Boaz

Salem

Navarro

2021

Bioactive Compounds in Health and Disease

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Obesity has been associated with adverse Coronavirus disease [COVID-19] outcomes; obesity is associated with sub-optimal immune function, including vitamin D and zinc deficiencies, two micronutrients essential for immune function, including anti-viral activity. The co-occurrence of vitamin D and zinc deficiencies have been documented. These exposures have been widely discussed in both scientific and popular literature. Thus, a critical review of the association between obesity, vitamin D and zinc, in relation to the COVID pandemic, is appropriate. Evidence strongly associates obesity and adverse COVID outcomes including hospitalization, intensive care hospitalization, need for mechanical ventilation and death. While the mechanisms associating vitamin D and zinc to immune function are well-delineated, clinical trials of these nutrients fail to identify efficacy in the prevention or treatment of COVID. Further studies are warranted in susceptible populations. It is important that healthcare professionals practice evidence-based care; thus at this point, neither vitamin D nor zinc can be recommended as a preventive or cure for COVID. Keywords: COVID, body weight, obesity, vitamin D, zinc

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Body composition predictors of outcome in patients with COVID-19

Cited by 31 publications

References 43 publications

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

COVID-19 infection and body weight: A deleterious liaison in a J-curve relationship

Body weight, vitamin D and zinc: A review of associations with coronavirus disease (COVID-19)

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