Body composition of Slovak midlife women with cardiovascular complications

Drozdová, Darina; Daňková, Zuzana; Čerňanová, Veronika Candráková; Siváková, Daniela

doi:10.1515/anre-2016-0013

Cited by 5 publications

(1 citation statement)

References 30 publications

(27 reference statements)

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“…Obesity is a global issue of great concern, and it is becoming more serious as living standards rise ( 3 ). Obesity has been shown to cause a variety of diseases, including cardiovascular ( 4 ) and cerebrovascular disease ( 5 ), diabetes ( 6 ), obstructive sleep apnea syndrome ( 7 ), and metabolic disorders ( 8 ). Observational studies have shown that NSOM may be associated with obesity, most of which is concentrated in the pediatric population ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Yan,

Chen

2024

Front. Med.

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BackgroundObservational studies have found that obesity is associated with the development of non-suppurative otitis media (NSOM), but the causality and pathogenesis are unclear. This study aimed to investigate the association between obesity, lipid metabolism, and NSOM at the genetic level.MethodsWe performed a bidirectional two-sample Mendelian randomization (MR) study to examine the causal relationship between obesity, lipid metabolism-related factors, and NSOM by using the datasets obtained from the IEU Open genome-wide association studies (GWAS) Project. Furthermore, a multivariate MR (MVMR) analysis on lipid indicators was conducted to validate the results. We then used obesity or body mass index (BMI) as the exposure and NSOM as the outcome to search for possible mediators in lipids and adipokines.ResultsUsing NSOM as the outcome, we found nine positive exposure results related to obesity and lipid metabolism. Among them, obesity, BMI, body fat percentage, waist circumference, hip circumference, and resistin were risk factors, while apolipoprotein A1 (apoA1), high-density lipoprotein cholesterol (HDL-C), and nerve growth factor (NGF) were protective factors. Then, we used the obesity and lipid metabolism-related factors as outcomes and NSOM as the exposure to perform the MR analysis, which failed to obtain positive results. In the MVMR analysis, we found that HDL cholesterol and apoA1 remained causally associated with NSOM after correction for other potential confounders. Simultaneously, when obesity or BMI was used as the exposure and NSOM as the outcome, HDL cholesterol or apoA1 served as mediators through a two-step MR analysis. The MR analysis for mediation, obesity, and BMI reduced the production of HDL or apoA1, which served as protective factors affecting the development of NSOM.ConclusionAt the genetic level, obesity and adiposity may promote the development of NSOM, while NSOM has no effect on obesity and adiposity. Obesity can also encourage the progress of NSOM by reducing HDL cholesterol/apoA1. Resistin may be a potential risk factor for NSOM, whereas NGF may be a potential protective factor.

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Section: Introductionmentioning

confidence: 99%

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Yan,

Chen

2024

Front. Med.

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Phase angle of bioimpedance at 50 kHz is associated with cardiovascular diseases: systematic review and meta-analysis

et al. 2022

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The variability of anthropometric and body composition parameters in middle-aged women associated with menopause and smoking

Sulis,

Švábová

2024

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Menopause and its related hormonal changes are associated with the variation of body composition, especially impacting adipose tissue metabolism and the reduction of lean mass. The purpose of the present study was to investigate the impact of smoking during menopause on the subsequent effects on body composition. The sample comprised of 572 Slovak women aged between 39 and 65 years (49.67±6.2). Standard anthropometric techniques were used to collect anthropometric measurements, whereas bioelectrical parameters were measured utilizing a mono-frequency bioimpedance analyzer (BIA 101). Data on menopausal status, physical activity, and smoking habits were obtained via a specific questionnaire. In postmenopausal women, our results showed a statistically significant difference between smokers and non-smokers in BMI, TBW%, ECW%, ICW%, MM%, FFM%, FM% (p < 0.05). No significant differences were observed in premenopausal women, although two-way analysis of covariance revealed a significant interaction between smoking and menopausal status on the FM% (p < 0.001), FFM% (p < 0.001), and MM% (p = 0.002), whilst controlling for age and physical activity. In our sample group of middle-aged women, the combined impact of menopause and smoking appeared to influence anthropometric parameters and body composition.

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Body composition of Slovak midlife women with cardiovascular complications

Cited by 5 publications

References 30 publications

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Phase angle of bioimpedance at 50 kHz is associated with cardiovascular diseases: systematic review and meta-analysis

The variability of anthropometric and body composition parameters in middle-aged women associated with menopause and smoking

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