Body composition in patients with type 2 intestinal failure

Abstract

Background Measurement of body composition is a valuable clinical tool for nutrition assessments, but there are no data on the merits of assessment modalities in type 2 intestinal failure (IF). The aim of this study was to evaluate the prevalence of low muscle mass and quality in type 2 IF, comparing bioelectric impedance analysis (BIA) and computed tomography (CT) at the third lumbar vertebra level. Methods Patients admitted with acute severe (type 2) IF to a national UK IF center who had BIA measurement and CT scan as part of routine care within 40 days of anthropometric measurement were included in this cross‐sectional study. Data were also collected on patient demographics and clinical characteristics. Results Forty‐four patients meeting inclusion criteria were included. Low muscle mass was detected in 37 out of 44 (84.1%) patients by CT scan and in 30 of out 44 (68.2%) by BIA. Low muscle quality was detected in 22 out of 44 (50%) patients by CT scan and in 40 out of 44 (90.1%) by BIA. Comparison of CT and BIA measurements showed a moderate correlation of muscle, Spearman ρ 0.65 (95% CI, 0.42–0.81; P < 0.001), and a strong correlation of body fat mass measurements, Spearman ρ 0.79 (95% CI, 0.62–0.89; P < 0.001). Conclusion This is the first study to demonstrate that low muscle mass is common in patients with type 2 IF, regardless of body composition assessment modality. A larger cohort study is required to validate the impact of low muscle mass and quality on clinical outcomes and the role of targeted interventions to improve the care of patients with type 2 IF.

An evaluation of plasma vitamin C concentrations in individuals requiring home parenteral nutrition

“…Specialist IF dietitians recorded weight, height and anthropometric measurement (mid‐arm muscle circumference and tricep skinfold), for which the methods are described elsewhere 9,10 . A pragmatic approach to dietary assessment of oral/enteral intake was undertaken, whereby experienced specialist IF dietitians took detailed diet histories of atypical dietary intake across the week.…”

Frequency and impact of enteric hyperoxaluria in pediatric short bowel syndrome: a retrospective single centre study

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